TAC Cancer Research Results

TAC, total antioxidant capacity: Click to Expand ⟱
Source:
Type:
Total antioxidant capacity (TAC) refers to the ability of a biological sample (such as blood, tissues, or food) to counteract oxidative stress by neutralizing free radicals and reactive oxygen species (ROS).

May have reduced levels in cancers.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
377- AgNPs,    Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis
- in-vitro, BC, SkBr3
ROS↑, Apoptosis↑, Bax:Bcl2↑, VEGF↑, Akt↓, PI3K↓, TAC↓, TOS↑, OSI↑, MDA↑, Casp3↑, Casp7↑,
3439- ALA,    The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles
- in-vitro, Nor, NA
*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,
7396- Amla,    Enhancing cognitive memory function using Phyllanthus emblica polysaccharides via modulating autophagy and reshaping the gut microbiota
- in-vivo, AD, NA
*Inflam↓, *antiOx↓, *GutMicro↑, *cognitive↑, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *IL4↑, *IL10↑, *TAC↑, *ATG5↑, *Beclin-1/ATG6↑, *LC3B↑, *LRP1↑, *BACE/β-secretase↓, *APP↓, *Aβ↓, *tau↓,
7408- Amla,    Fresh Phyllanthus emblica (Amla) Fruit Supplementation Enhances Milk Fatty Acid Profiles and the Antioxidant Capacities of Milk and Blood in Dairy Cows
- Trial, Nor, NA
*Dose↝, *TAC↑, *SOD↑, *ALB↑, *ROS↓, *other↑,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
5638- BCA,    Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway
- in-vitro, Oral, NA
tumCV↓, ROS↑, MMP↓, TumCMig↓, TAC↓, lipid-P↓, NF-kB↓, Apoptosis↑,
729- Bor,    Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
- in-vitro, GBM, U87MG - in-vivo, Nor, HaCaT
TOS↑, TumCG↓, MDA↑, SOD↑, Catalase↑, TAC↓, GSH↓, BRAF↑, MAPK↓, PTEN↓, Raf↓, *toxicity↓,
4270- Bos,    Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *Aβ↓, *TNF-α↓, *IL1β↓, *lipid-P↓, *TAC↑, *BDNF↑, *β-catenin/ZEB1↑, *Dose↑,
8979- BRice,    Supplementation of black rice pigment fraction improves antioxidant and anti-inflammatory status in patients with coronary heart disease
- Trial, CardioV, NA
*Dose?, *TAC↑, *VCAM-1↓, *hs-CRP↓, *cardioP↑,
7944- BuckWS,    Extracts from Tartary Buckwheat Sprouts Restricts Oxidative Injury Induced by Hydrogen Peroxide in HepG2 by Upregulating the Redox System
- in-vitro, Nor, HepG2
*ROS↓, *MMP↑, *TAC↑, *SOD↑, *Catalase↑, *GSTA1↑, *NRF2↑, *NQO1↑, *HO-1↑,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *Synergy↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
5873- CA,    Carnosic acid serves as a dual Nrf2 activator and PTEN/AKT suppressor to inhibit traumatic heterotopic ossification
- vitro+vivo, Nor, NA
*NRF2↑, *NOX↓, *TAC↑, *ROS↓, *NQO1↑, *p‑PTEN↑, RUNX2↓, SOX9↓,
8701- CAP,    Comparative assessment of direct and indirect cold atmospheric plasma effects, based on helium and argon, on human glioblastoma: an in vitro and in vivo study
- vitro+vivo, GBM, GBM - in-vitro, GBM, U87MG
Apoptosis↑, TumCG↓, TumCMig↓, ROS↑, TAC↓, eff↝, TumVol↓, OS↑, GFAP↓, P53↑, motorD↑,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2/PTGS2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2/PTGS2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
8993- Citicoline,    Citicoline protects against lead-induced oxidative injury in neuronal PC12 cells
- in-vitro, Nor, PC12
*Apoptosis↓, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GSH↑, *BAX↓, *Bcl-2↑, *Casp3↓, *neuroP↑, *ROS↓,
6529- CRV,    D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *SOD↑, *GSH↑, *TAC↑, *eff↑, *TGF-β1↓, *SMAD3↓, *MMP9↑, *NRF2↑, *antiOx↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *NO↓, *cAMP↑, *ROS↓,
6221- CUR,    Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer
- Review, Var, NA
NF-kB↓, Imm↑, *TAC↑, *MDA↓, ROS↑, TumAuto↑, TumCCA↑, Keap1↑, ChemoSen↑, ER Stress↑, eff↓, TrxR↓, STAT3↓, *BioAv↓,
2811- CUR,    Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study
- Human, Pca, NA
*antiOx↑, radioP↑, RadioS∅, *TAC↑, *SOD↓,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
6803- EA,    Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial
- Trial, IBD, NA
*Dose↝, *MDA↓, *TAC↑, *CRP↓, *IL6↓, *Inflam↓, *ROS↓, *QoL↑, *toxicity↓,
6822- EMD,    Behavioral, Histopathological, and Biochemical Implications of Aloe Emodin in Copper-Aβ-Induced Alzheimer's Disease-like Model Rats
- in-vivo, AD, NA
*Copper↓, *Aβ↓, *memory↑, *cognitive↑, *Apoptosis↓, *TAC↑, *Inflam↓,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, Synergy↑, Synergy↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
6885- FA,    Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways
- in-vivo, Nor, NA
*Dose↝, *TAC↑, *MDA↓, *RenoP↑, *PI3K↓, *Akt↓, *ROS↓, *Inflam↓, PPARγ↝, *NF-kB↓, *IL6↓, *TNF-α↓, *iNOS↓, *ALAT↓, *AST↓, *Urea↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑,
8608- FSO,  Cisplatin,    Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer
- in-vivo, Cerv, NA
TumVol↓, TumW↓, ChemoSen↑, *TAC↑, lipid-P↑, CD8+↑, IFN-γ↑, IL4↓, E6↓, E7↓, P53↑,
8607- FSO,    Effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials
- Review, Obesity, NA
*IL6↓, *MDA↓, *TAC↑,
8604- FSO,  VitD3,    An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management
- Trial, Diabetic, NA
*TAC↑, *Weight↓, *glucose↓, *Insulin↓, *TG/TAG↓, *TC↓, *QoL↑, *Pain↓, *toxicity↓, *Dose↝,
7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *ROS↓, *TAC↑, *IgE↓, *Dose↝, *NLR↓, *IL4↓, *IL5↓, *IL13↓, *GM-CSF↓, *NO↓, *GPx↑, *Eos↓, *antiAll↑,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7546- HYP,    Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap₁-Nrf₂-ARE signaling pathway
- in-vitro, Nor, L02
*TAC↑, *GPx↑, *Catalase↑, *ROS↓, *MMP↓, *LDH↑, *HO-1↑, *NRF2↑,
7759- ISL,  Rad,    Isoliquiritigenin, a Bioactive Blood Component Derived from Licorice, Activates Nrf2 Enzymes to Confer Protection Against Radiation-Induced Nerve Injury
- vitro+vivo, Nor, PC12
*radioP↑, *LDH↓, *ROS↓, *SOD1↑, *GSH↑, *TAC↑, *NRF2↓, *cognitive↑, *Learn↑, *memory↑,
7903- IVT,    Inhibition of advanced glycation end products by Isovitexin alleviates intestinal damage: Toward dietary strategies for gut health
- in-vivo, Nor, NA
*AGEs↓, *TAC↑, *IBI↑, *TJ↑, *ROS↓, *Apoptosis↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
9064- L-THE,    L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
- in-vivo, Stroke, NA
*Stroke↓, *Bcl-2↑, *BAX↓, *Casp3↓, *ROS?, *MDA?, *NO?, *TAC↑, *GSH↑, *SOD↑, *cardioP↑, *JAK2↑, *STAT3↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
209- MFrot,  MF,    The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study
- Human, Nor, NA
*SOD↑, *Catalase↑, *ROMO1↑, *MDA↓, *TAC↑, *ROS↓,
8470- Mg,  Z,    The Effects of Magnesium and Zinc Co-Supplementation on Biomarkers of Inflammation and Oxidative Stress, and Gene Expression Related to Inflammation in Polycystic Ovary Syndrome: a Randomized Controlled Clinical Trial
- Trial, Nor, NA
*Dose?, *CRP↓, *PCO↓, *TAC↑, *IL1↓, *TNF-α↓,
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8909- MO,    Effect of Moringa oleifera on inflammatory diseases: an umbrella review of 26 systematic reviews
- Review, Nor, NA
*Ingr↝, *LDL↓, *TG/TAG↓, *TC↓, *HDL↑, *VLDL↓, *ROS↓, *TAC↑, *HK2↑, *Glycolysis↑, *GLUT4↑, Apoptosis↑, P53↑, ROS↑, NF-kB↓, TumCP↓, TumCCA↑, COX2/PTGS2↓, NO↓, MAP2K1/MEK1↓, *GSTs↑, *NQO1↑, *NRF2↑, *ARE↑,
8913- MO,    Moringa oleifera Lamk. as a Promising Adjunct Therapeutic Candidate: A Narrative Review of Human Studies and Published Case Reports
- Review, Var, NA
*Imm↑, *antiOx↑, *AntiDiabetic↑, *Ingr↝, *Ingr↝, *TAC↑, *IL6↓, *Sleep↑,
8900- MOR,  Cisplatin,    Morin Hydrate Mitigates Cisplatin-Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice
- in-vivo, Nor, NA
Dose↝, RenoP↑, *ROS↓, *TAC↑, *Inflam↓,
8873- MOR,  Zeo,    Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer's Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities
- in-vivo, AD, NA
*neuroP↑, *p‑tau↓, *antiOx↑, *Ferroptosis↓, *NRF2↑, *Learn↑, *memory↑, *AChE↓, *HO-1?, *SOD↑, *TAC↑, *GPx4↑, *Synergy↑, *TLR4↓, *BAX↓, *Bcl-2↑, *BDNF↑, *Wnt↑, *β-catenin/ZEB1↑, *APP↓, *BACE/β-secretase↓,

Showing Research Papers: 1 to 50 of 73
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 73

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↓, 3,   Iron↝, 1,   Keap1↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 2,   OSI↑, 1,   ROS↓, 4,   ROS↑, 10,   ROS⇅, 1,   SOD↓, 2,   SOD↑, 1,   TAC?, 1,   TAC↓, 6,   TAC↑, 3,   TOS↑, 2,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MFN2↑, 1,   mtDam↑, 2,   OCR↑, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↑, 1,   Glycolysis↓, 1,   TCA↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↑, 11,   BAD↑, 1,   Bak↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   cl‑Casp3⇅, 1,   Casp7↑, 2,   Casp8↑, 1,   Casp9↑, 4,   Cyt‑c↑, 3,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   p38↑, 1,   PDCD4↑, 1,   PUMA↑, 1,   survivin↓, 3,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 1,   p‑Akt↓, 1,   BRAF↑, 1,   ERK↓, 1,   JAK↓, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 2,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↝, 1,   p‑mTOR↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 2,   PTEN↓, 1,   Raf↓, 1,   Sp1/3/4↓, 1,   STAT3↓, 2,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

FOXO3↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   other↑, 1,   RUNX2↓, 1,   SOX9↓, 1,   tumCV↓, 4,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 8,   PARP↑, 1,   cl‑PARP↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 2,   P21↑, 2,   p27/CDKN1B↑, 2,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Gli1↓, 1,   Ki-67↓, 2,   NOTCH⇅, 1,   NOTCH2↓, 1,   PTCH1↓, 1,   Smo↓, 1,   TumCG↓, 3,   TumCP↓, 6,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   LRP1↓, 1,   MMP2↓, 1,   MTA1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TIMP2↓, 1,   TumCI↓, 7,   TumCMig↓, 5,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 2,   NO↓, 1,   VEGF↓, 3,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 3,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD8+↑, 1,   COX2/PTGS2↓, 4,   DR4↑, 2,   IFN-γ↑, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 3,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 2,   NF-kB↓, 7,   PD-L1↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 5,   Dose↝, 3,   eff↓, 2,   eff↑, 1,   eff↝, 1,   P-gp/ABCB1↓, 1,   RadioS∅, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   BRAF↑, 1,   E6↓, 1,   E7↓, 1,   IL6↓, 3,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   cardioP↑, 3,   chemoP↑, 1,   hepatoP↑, 1,   motorD↑, 1,   neuroP↑, 1,   NKG2D↑, 1,   OS↑, 2,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 2,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 175

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 19,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 18,   Copper↓, 1,   Fenton↓, 1,   GPx↑, 15,   GPx4↑, 2,   GSH↑, 19,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 4,   H2O2↓, 3,   HDL↑, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 11,   Keap1↓, 1,   lipid-P↓, 13,   MDA?, 1,   MDA↓, 24,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 24,   ONOO↓, 1,   PCO↓, 1,   ROMO1↑, 1,   ROS?, 1,   ROS↓, 39,   ROS↑, 1,   SOD↓, 1,   SOD↑, 28,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 62,   TAC∅, 1,   TBARS↓, 2,   Thiols↑, 1,   TOS↓, 1,   TOS↑, 1,   TrxR1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   mtDam↓, 1,   PGC-1α↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 7,   AMPK↑, 3,   ATP↑, 1,   cAMP↑, 1,   CRM↑, 2,   glucose↓, 2,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 3,   HK2↑, 1,   LDL↓, 4,   NADPH↑, 1,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   BAX↓, 4,   Bcl-2↑, 6,   Casp3↓, 6,   Cyt‑c↓, 1,   Ferroptosis↓, 2,   iNOS↓, 6,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 3,   p‑CREB↑, 1,   ERK↓, 1,   JAK2↑, 1,   MAPK↓, 5,   PI3K↓, 1,   PI3K↑, 2,   PKCδ↑, 1,   PTEN↓, 2,   p‑PTEN↑, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↑, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP90↓, 1,   NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   MitoP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Wnt↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   LRP1↑, 1,   MMP9↑, 1,   PAI-1/SERPINE1↓, 1,   SMAD3↓, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 2,   NO?, 1,   NO↓, 11,   VCAM-1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 1,   MMP↑, 3,   NHE3↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↑, 1,   COX2/PTGS2↓, 4,   Eos↓, 1,   FOXP3↑, 1,   GM-CSF↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IgE↓, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 3,   IL13↓, 1,   IL1β↓, 10,   IL2↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 12,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 23,   Inflam↑, 1,   IRF3↓, 1,   MyD88↓, 1,   NeuroI↓, 3,   NF-kB↓, 16,   NK cell↑, 1,   NLRP3↓, 2,   PGE2↓, 2,   TLR2↓, 2,   TLR4↓, 5,   TNF-α↓, 14,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 3,   AChE↓, 6,   BDNF↑, 6,   ChAT↑, 1,   GDNF↑, 1,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 3,   Aβ↓, 8,   Aβ42↓, 2,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 4,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   PPARγ↑, 1,   PR↝, 1,   testos?, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv⇅, 1,   BioAv↝, 3,   ChemoSen↑, 1,   Dose?, 2,   Dose↑, 1,   Dose↝, 10,   eff↑, 8,   GSTA1↑, 2,   Half-Life↑, 1,   Half-Life↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALB↑, 1,   ALP↓, 1,   anemia↓, 1,   AST↓, 6,   BMD↑, 1,   BP↓, 1,   BP↝, 1,   BUN↓, 3,   creat↓, 2,   CRP↓, 4,   Ferritin↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 12,   LDH↓, 2,   LDH↑, 1,   NLR↓, 1,   NOS2↓, 1,   RBC↑, 1,   TC↓, 3,   TG/TAG↓, 3,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 3,   AntiArt↑, 2,   AntiCan↑, 2,   antiD↓, 1,   AntiDiabetic↑, 4,   cardioP↑, 10,   chemoP↑, 1,   cognitive↓, 1,   cognitive↑, 8,   hepatoP↑, 5,   Learn↑, 4,   memory↑, 9,   neuroP?, 1,   neuroP↑, 14,   Obesity↓, 1,   Pain↓, 1,   QoL↑, 3,   radioP↑, 1,   RenoP↑, 6,   Sleep↑, 2,   Strength↑, 1,   Stroke↓, 2,   toxicity↓, 5,   toxicity⇅, 1,   toxicity↝, 3,   toxicity∅, 1,   Weight↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 3,   GutMicro↑, 6,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 261

Scientific Paper Hit Count for: TAC, total antioxidant capacity
4 Quercetin
3 Spirulina(Arthrospira/Limnospira)
3 Flaxseed Oil
3 Hyperoside
3 Morin
3 Resveratrol
3 Thymoquinone
2 Silver-NanoParticles
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Curcumin
2 Cisplatin
2 Lactoferrin/Talactoferrin
2 Lycopene
2 Melatonin
2 Moringa oleifera
2 Selenium NanoParticles
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Biochanin A
1 Boron
1 Boswellia (frankincense)
1 Black Rice, Oryza sativa
1 buckwheat sprouts
1 Caffeic acid
1 Carnosic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Carvacrol
1 Chlorogenic acid
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Citicoline, CDP-Choline
1 Carvone
1 Chlorella (Chlorella vulgaris)
1 Ellagic acid
1 Emodin
1 Eugenol
1 Ferulic acid
1 Vitamin D3
1 Hydrogen Gas
1 Isoliquiritigenin
1 Radiotherapy/Radiation
1 Isovitexin
1 Kaempferol
1 L-Theanine
1 Licochalcone A
1 Metformin
1 Magnetic Field Rotating
1 Magnetic Fields
1 Magnesium
1 Zinc
1 Zeolite
1 Marjoram (Origanum majorana)
1 Piperine
1 Rosmarinic acid
1 Shikonin
1 Terminalia bellirica
1 Gallic acid
1 Aflavin-3,3′-digallate
1 5-fluorouracil
1 Thymol-Thymus vulgaris
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:626  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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