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| Glutathione reductase is an enzyme that plays a crucial role in maintaining the balance of glutathione, a powerful antioxidant found in cells. Glutathione is involved in various cellular processes, including detoxification, cell signaling, and protection against oxidative stress.
Glutathione reductase helps maintain the levels of reduced glutathione (GSH) in cells. Cancer cells often have elevated levels of glutathione reductase, which allows them to maintain high levels of GSH and resist oxidative stress. Glutathione reductase has been shown to promote cell proliferation and survival in cancer cells. Elevated levels of glutathione reductase have been found in various types of cancer, including breast, lung, and colon cancer. Several studies have shown that inhibiting glutathione reductase can increase the sensitivity of cancer cells to chemotherapy and radiation therapy, and may also induce apoptosis in cancer cells. |
| 1902- | AgNPs, | Modulation of the mechanism of action of antibacterial silver N-heterocyclic carbene complexes by variation of the halide ligand |
| - | in-vitro, | Var, | NA |
| 400- | AgNPs, | MF, | Polyvinyl Alcohol Capped Silver Nanostructures for Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field |
| - | in-vitro, | Laryn, | HEp2 |
| 3269- | ALA, | Sulfur-containing therapeutics in the treatment of Alzheimer’s disease |
| - | Review, | AD, | NA |
| 3160- | Ash, | Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal |
| - | Review, | Var, | NA |
| 4303- | Ash, | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review |
| - | Review, | AD, | NA |
| 2749- | BetA, | Anti-Inflammatory Activities of Betulinic Acid: A Review |
| - | Review, | Nor, | NA |
| 4265- | CA, | Potential applications of nanomedicine for treating Parkinson's disease |
| - | Review, | Park, | NA |
| 5847- | CAP, | An updated review on molecular mechanisms underlying the anticancer effects of capsaicin |
| - | in-vitro, | Liver, | HepG2 |
| 5766- | CAPE, | A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model |
| - | in-vivo, | Nor, | NA |
| 5887- | CAR, | TV, | Antitumor Effects of Carvacrol and Thymol: A Systematic Review |
| - | Review, | Var, | NA |
| 5881- | CAR, | Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties |
| - | Review, | Nor, | NA |
| 5909- | CAR, | Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats |
| - | in-vivo, | HCC, | NA |
| 5894- | CAR, | Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential |
| - | Review, | Var, | NA |
| 7165- | CHA, | The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase |
| - | in-vitro, | Cerv, | HeLa |
| 6128- | CHr, | Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential |
| - | Review, | Nor, | NA | - | Review, | Var, | NA | - | Review, | AD, | NA |
| 6527- | CRV, | Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events |
| - | in-vivo, | Melanoma, | NA |
| 6520- | CRV, | Health Benefits and Pharmacological Properties of Carvone |
| - | Review, | Nor, | NA |
| 7423- | CS, | Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats |
| - | in-vivo, | Nor, | NA |
| 2818- | CUR, | Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways |
| - | Review, | AD, | NA |
| 5012- | DSF, | Cu, | Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems |
| - | Review, | Var, | NA |
| 3721- | EGb 761, | Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice |
| - | Review, | AD, | NA |
| - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | DU145 |
| 6561- | GSL, | Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes |
| - | in-vivo, | Nor, | NA |
| 7782- | ISL, | BUT, | SCP, | Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway |
| - | in-vitro, | AD, | SH-SY5Y |
| 9066- | L-THE, | Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters |
| - | in-vivo, | CRC, | NA |
| 9072- | L-THE, | doxoR, | Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats |
| - | in-vivo, | Nor, | NA |
| 2906- | LT, | Luteolin, a flavonoid with potentials for cancer prevention and therapy |
| - | Review, | Var, | NA |
| 2919- | LT, | Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence |
| - | Review, | Var, | NA |
| 2916- | LT, | Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3528- | Lyco, | The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene |
| - | Review, | Nor, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3277- | Lyco, | Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent |
| - | Review, | Var, | NA |
| 2544- | M-Blu, | Methylene blue and its importance in medicine |
| - | Review, | Nor, | NA |
| 4111- | MF, | Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell |
| - | Review, | Arthritis, | NA |
| 3462- | MF, | The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions |
| - | in-vitro, | Nor, | NA |
| 3484- | MF, | Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2 |
| - | in-vitro, | Nor, | NA |
| 1777- | MLT, | Melatonin as an antioxidant: under promises but over delivers |
| - | Review, | Var, | NA |
| 3844- | MO, | Review of the Safety and Efficacy of Moringa oleifera |
| - | Review, | Nor, | NA |
| 6489- | Nimb, | Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model |
| - | in-vivo, | Pca, | DU145 | - | in-vivo, | Pca, | LNCaP |
| 9058- | PatchO, | Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation |
| - | in-vivo, | LiverDam, | NA |
| 3249- | PBG, | Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence |
| - | Review, | Var, | NA |
| 3595- | PI, | Black pepper and health claims: a comprehensive treatise |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 2651- | PLB, | Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence |
| - | Review, | Var, | NA |
| 3930- | PTS, | A Review of Pterostilbene Antioxidant Activity and Disease Modification |
| - | Review, | Var, | NA | - | Review, | adrenal, | NA | - | Review, | Stroke, | NA |
| 4703- | PTS, | RES, | Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging - A scoping review |
| - | in-vivo, | Nor, | NA |
| 79- | QC, | Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats |
| - | in-vivo, | Pca, | NA |
| 3612- | RES, | Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential |
| - | Review, | AD, | NA |
| 3026- | RosA, | Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts |
| - | in-vitro, | Nor, | NA |
| 4911- | Sal, | MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells |
| - | in-vitro, | Var, | DU145 |
| 9281- | SES, SSM, | LIGs, | A comprehensive review on the anti-cancer properties of sesame lignans: chemical composition, molecular mechanisms and prospects |
| - | Review, | Var, | NA |
| 4199- | SFN, | Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:633 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid