Fibronectin Cancer Research Results

Fibronectin, Fibronectin: Click to Expand ⟱
Source:
Type:
Fibronectin is a high-molecular weight glycoprotein that plays a crucial role in cell adhesion, migration, and tissue repair. It is a key component of the extracellular matrix (ECM) and is involved in various cellular processes, including cell signaling, differentiation, and survival. Studies have shown that fibronectin is overexpressed in various types of cancer, including breast, lung, colon, and ovarian cancer. High levels of fibronectin have been associated with poor prognosis and reduced survival in cancer patients.
Scientific Papers found: Click to Expand⟱
1299- BBR,    Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review
- Review, Var, NA
TumCCA↑, TP53↑, COX2/PTGS2↓, Bax:Bcl2↑, ROS↑, VEGFR2/KDR/Flk1↓, Akt↓, ERK↓, MMP2↓, MMP9↓, IL8↑, P21↑, p27/CDKN1B↑, E-cadherin↓, Fibronectin↓, cMyc↓,
9196- BITC,    Benzyl Isothiocyanate Inhibits Epithelial-Mesenchymal Transition in Cultured and Xenografted Human Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, PC, PL45
TumCG↓, EMT↓, E-cadherin↑, OCLN↑, Vim↓, Fibronectin↓, Snail↓, cMET↓, Slug↓,
1104- CAR,    Carvacrol Ameliorates Transforming Growth Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway In Hk-2 Cells
- in-vitro, Kidney, HK-2
tumCV↓, COL4↓, COL1↓, Fibronectin↓, E-cadherin↑, Snail↑, Vim↑, α-SMA↑, PI3K↓, Akt↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
TumCI↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, STAT3↓, miR-301a-3p↓, STAT↓, N-cadherin↓, Vim↓, Fibronectin↓, p‑JAK↓, p‑JAK2↓, p‑JAK3↓, p‑STAT1↓, p‑STAT2↓, E-cadherin↑,
470- CUR,    Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line
- in-vitro, Ovarian, SKOV3
Wnt/(β-catenin)↓, EMT↓, DNMT3A↓, cycD1/CCND1↓, cMyc↓, Fibronectin↓, Vim↓, E-cadherin↑, SFRP5↑,
420- CUR,    Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Vim↓, Fibronectin↓, β-catenin/ZEB1↓, E-cadherin↓, CD44↑, CD24↓, OCT4↓, Nanog↓, SOX2↓,
4681- EGCG,    Epigallocatechin-3-Gallate Prevents the Acquisition of a Cancer Stem Cell Phenotype in Ovarian Cancer Tumorspheres through the Inhibition of Src/JAK/STAT3 Signaling
- in-vitro, Ovarian, ES-2
TumCP↓, Apoptosis↑, Nanog↓, SOX2↓, Fibronectin↓, CD133↓,
6915- FIS,  SRF,    Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
- in-vitro, Melanoma, NA
EMT↓, TumCP↓, PI3K↓, Synergy↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, Synergy↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
7019- Fuc,    Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43
- vitro+vivo, HCC, HUH7
TumCI↓, p42↑, p44↑, MAPK↑, TumMeta↓, hepatoP↑, *antiOx↑, *TumCP↓, Vim↓, E-cadherin↓, Fibronectin↓, NDRG1↑, VMP-1↑, TumMeta↓,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
9294- MF,    Pulsed electromagnetic fields in muscle and tendon injuries: a narrative review of preclinical and clinical evidence
- Review, Nor, NA
*VEGF↑, *COL1↑, *IL6↑, *IL10↑, *Fibronectin↑, *Pain↓, *other↑, *Inflam↓,
8675- MLT,    Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update
- Review, Var, NA
ChemoSen↑, TumCP↓, TumCMig↓, CSCs↓, MDR1↓, chemoP?, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Bcl-2↓, Mcl-1↓, IAP1↓, survivin↓, PCNA↓, Ki-67↓, CC(CDKs/cyclins)↓, TumCMig↓, TumCI↓, Fibronectin↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, Synergy↑, Synergy↑, OCT4↓, Nanog↓, ERCC1↓, P-gp/ABCB1↓, EMT↓, Synergy↑, ChemoSen↑,
8885- MOR,    Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
IL1β↓, IL18↓, IL6↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, uPAR↓, uPA↓, EMT↓, Fibronectin↓, N-cadherin↓, Vim↓, NLRP3↓, MAPK↓,
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,
1047- RES,    Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells
- in-vitro, Lung, H1299 - in-vitro, Lung, A549 - in-vitro, Lung, H460
PD-L1↑, Snail↑, E-cadherin↓, N-cadherin↑, Fibronectin↑, Vim↑, Axin2↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
3190- SFN,    Sulforaphane inhibits TGF-β-induced fibrogenesis and inflammation in human Tenon’s fibroblasts
- in-vitro, Nor, NA
*Fibronectin↓, *α-SMA↓, *ITGB1↓, *ITGA5↓, *IL6↓, *IL8↓, Inflam↓,
1014- SFN,    Sulforaphane Modulates Cell Migration and Expression of β-Catenin and Epithelial Mesenchymal Transition Markers in Breast Cancer Cells
- in-vitro, BC, MDA-MB-231
Zeb1↓, Apoptosis↑, Fibronectin↓, CLDN1↓, β-catenin/ZEB1↓, EMT↓,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
1821- VitK3,    Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration
- in-vitro, Oral, NA - in-vitro, Nor, HEK293 - in-vitro, Nor, HaCaT
selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSTs↓, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↑, 1,   MDA↓, 1,   NRF2↓, 2,   ROS↓, 1,   ROS↑, 7,   ROS⇅, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   mtDam↑, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   ALAT↓, 1,   AMPK↑, 1,   ATP↓, 1,   GlutMet↓, 1,   HK2↓, 1,   LDL↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 6,   BAD↑, 2,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Bcl-xL↓, 1,   BIM↑, 2,   Casp3↑, 5,   cl‑Casp8↑, 1,   Casp9↑, 1,   CellShr↑, 1,   Cyt‑c↑, 4,   Diablo↑, 2,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   IAP1↓, 1,   iNOS↓, 2,   Mcl-1↓, 4,   MOMP↑, 1,   p38↓, 1,   survivin↓, 1,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↓, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   CK2↓, 1,   cMET↓, 1,   EGFR↓, 3,   ERK↓, 2,   p‑ERK↓, 1,   p‑JAK↓, 1,   p‑JAK2↓, 1,   p‑JAK3↓, 1,   MAPK↓, 1,   MAPK↑, 1,   MEK↓, 1,   mTOR↓, 5,   p42↑, 1,   PI3K↓, 5,   STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   cJun↓, 2,   cMyc↓, 2,   DNMT3A↓, 1,   FOXO4↓, 1,   HDAC↓, 1,   miR-301a-3p↓, 1,   Myc↓, 1,   NDRG1↑, 1,   OCT4↓, 2,   SOX2↓, 2,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   p62↓, 1,   TumAuto↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   ERCC1↓, 1,   hTERT/TERT↓, 1,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,   POLD1↓, 1,   TOP1↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK2↓, 2,   CDK4↓, 2,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 5,   Ki-67↓, 2,   P21↑, 2,   p27/CDKN1B↑, 1,   Securin↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Axin2↓, 1,   CD133↓, 1,   CD24↓, 1,   cFos↓, 2,   CSCs↓, 3,   Diff↑, 1,   IGF-1↓, 1,   Ki-67↓, 2,   Nanog↓, 3,   NOTCH1↑, 1,   SFRP5↑, 1,   p‑STAT1↓, 1,   TumCG↓, 2,   TumCP↓, 4,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   COL1↓, 2,   COL4↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 11,   EMT↓, 13,   Fibronectin↓, 20,   Fibronectin↑, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 10,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 9,   N-cadherin↓, 7,   N-cadherin↑, 1,   p44↑, 1,   Slug↓, 5,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 7,   Snail↑, 2,   TET1↑, 1,   TGF-β↓, 1,   TumCI↓, 9,   TumCMig↓, 6,   TumMeta↓, 5,   Twist↓, 4,   uPA↓, 3,   uPAR↓, 1,   Vim?, 1,   Vim↓, 14,   Vim↑, 2,   Zeb1↓, 5,   α-SMA↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   eNOS↓, 1,   Hif1a↓, 2,   VCAM-1↓, 1,   VEGF↓, 4,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 2,   MMP↓, 3,   MMP↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↑, 1,   CD8+↑, 1,   COX2/PTGS2↓, 6,   COX2/PTGS2↑, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL18↓, 1,   IL1β↓, 4,   IL6↓, 3,   IL8↓, 1,   IL8↑, 1,   Imm↑, 1,   Inflam↓, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   NLRP3↓, 1,   p65↓, 2,   PD-1↓, 1,   PD-L1↑, 1,   PGE2↓, 3,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 2,   TRADD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 5,   Dose↝, 2,   MDR1↓, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   selectivity↑, 2,   Synergy?, 1,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   CRP↓, 1,   EGFR↓, 3,   hTERT/TERT↓, 1,   IL6↓, 3,   LDH↓, 1,   Myc↓, 1,   PD-L1↑, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoP?, 1,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   RenoP↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 236

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 1,   GSH↑, 1,   Keap1↓, 1,   lipid-P↓, 1,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CREB↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 2,   Fibronectin↑, 1,   ITGA5↓, 1,   ITGB1↓, 1,   MMP2↓, 1,   Smad7↑, 1,   TGF-β↓, 1,   Vim↓, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↑, 1,   IL6↓, 1,   IL6↑, 1,   IL8↓, 1,   Inflam↓, 2,   NeuroI↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AST↓, 1,   creat↓, 1,   IL6↓, 1,   IL6↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 3,   Pain↓, 1,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 53

Scientific Paper Hit Count for: Fibronectin, Fibronectin
3 Curcumin
3 Fisetin
2 Resveratrol
2 Sulforaphane (mainly Broccoli)
1 Berberine
1 Benzyl isothiocyanate
1 Carvacrol
1 Chrysin
1 EGCG (Epigallocatechin Gallate)
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Grapeseed extract
1 Proanthocyanidins
1 Magnetic Fields
1 Melatonin
1 Morin
1 Piperine
1 salinomycin
1 Spirulina(Arthrospira/Limnospira)
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:654  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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