miR-29b Cancer Research Results

miR-29b, miR-29b: Click to Expand ⟱
Source:
Type:
miR-29b is a microRNA that has been extensively studied for its role in cancer. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation.

miR-29b has been found to act as a tumor suppressor in various types of cancer, including lung, breast, colon, and liver cancer. It targets several genes involved in cell proliferation, apoptosis, and metastasis, including:
-Collagen genes (COL1A1, COL1A2, COL3A1), which are involved in tumor cell invasion and metastasis.
-Cell cycle regulators (CDK6, CCND1), which promote cell proliferation.
-Anti-apoptotic genes (MCL1, BCL2), which inhibit programmed cell death.
-Epithelial-to-mesenchymal transition (EMT) regulators (ZEB1, ZEB2), which promote tumor cell migration and invasion.

Downregulation of miR-29b has been observed in various cancers, and this downregulation is often associated with poor prognosis and aggressive tumor behavior. Conversely, overexpression of miR-29b has been shown to inhibit tumor growth, induce apoptosis, and suppress metastasis in cancer cells.
Scientific Papers found: Click to Expand⟱
4820- ASTX,    Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p
- in-vitro, NPC, NA
TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, Bcl-2↓, P21↑, BAX↑, PI3K↓, Akt↓, NF-kB↓, miR-29b↑,
4812- ASTX,    Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a
- in-vitro, CRC, HCT116
miR-29b↑, miR-200b↑, MMP2↓, Zeb1↓, EMT↓, Apoptosis↑, ERK↓, MAPK↓, PI3K↓, Akt↓, MMPs↓, TumMeta↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, Synergy↑, chemoPv↑, BioAv↓,
422- CUR,    Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines
- in-vitro, BC, HCC-38 - in-vitro, BC, T47D
BRCA1↑, TET1↑, DNMT3A↑, DNMT1↓, SNCG↓, miR-29b↓, miR-29b↑,
9177- ITCs,  SFN,    Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy
- Review, Var, NA
CSCs↓, GutMicro↑, Bacteria↓, TumCCA↑, Apoptosis↑, TumAuto↑, angioG↓, TumCI↓, TumMeta↓, NRF2↑, Glycolysis↓, Wnt↓, β-catenin/ZEB1↓, HH↓, NOTCH↓, NK cell↑, EMT↓, angioG↓, BioAv↓, BioAv↑, AntiBio↑, Bacteria↓, HK2↓, PDH↓, OXPHOS↓, AKT1↓, ACC1↓, FASN↓, ACC-α↓, ACLY↓, SREBP1/SREBF1↓, OCT4↓, Nanog↓, YAP/TEAD↓, miR-21↓, miR-29b↓, ALDH1A1↓, miR-140↑, CD44↓, BMI1↓, miR-200c↑, TumCG↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, α-SMA↓, Slug↓, Snail↓, Twist↓, DNAdam⇅, BioAv↓, ChemoSen↑,
8366- LT,    Preliminary Evidence on Safety and Clinical Efficacy of Luteolin for Patients With Prostate Cancer Under Active Surveillance
- Trial, Pca, NA
Dose↝, eff↑, SD↑, Ki-67↓, AR↓, NKX3.1↓, miR-29b↑, miR-30a-5p↑,
2985- RES,    Resveratrol Inhibits Diabetic-Induced Müller Cells Apoptosis through MicroRNA-29b/Specificity Protein 1 Pathway
- in-vivo, Nor, NA - vitro+vivo, Diabetic, NA
*Sp1/3/4↓, *miR-29b↑,
3430- TQ,    Targeting microRNAs with thymoquinone: a new approach for cancer therapy
- Review, Var, NA
miR-29b↑, Sp1/3/4↓, TumCG↓, Rac1↓, angioG↓, TumMeta↓,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OXPHOS↓, 1,   PDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 1,   AMPK↑, 1,   FASN↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   cFLIP↓, 1,   Mcl-1↓, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   AKT1↓, 1,   ERK↓, 1,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 2,   Sp1/3/4↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3A↑, 1,   miR-140↑, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-21↓, 1,   miR-29b↓, 3,   miR-29b↑, 5,   miR-30a-5p↑, 1,   OCT4↓, 1,   SD↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   DNAdam⇅, 1,   NKX3.1↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   Ki-67↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   BMI1↓, 1,   CSCs↓, 1,   HH↓, 1,   IGFBP1↑, 1,   Ki-67↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   TumCG↓, 2,   TumCP↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 2,   MMP2↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   Rac1↓, 1,   Slug↓, 1,   Snail↓, 1,   TET1↑, 1,   TumCI↓, 3,   TumCMig↓, 1,   TumMeta↓, 3,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   NF-kB↓, 2,   NK cell↑, 1,  

Protein Aggregation(tgid=19) ⓘ

SNCG↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BRCA1↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 1,  
Total Targets: 95

Pathway results for Effect on Normal Cells:


Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-29b↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: miR-29b, miR-29b
2 Astaxanthin
1 Berberine
1 Curcumin
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
1 Luteolin
1 Resveratrol
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:658  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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