SOCS-3 Cancer Research Results

SOCS-3, Suppressor of Cytokine Signaling 3: Click to Expand ⟱
Source:
Type:
SOCS-3) is a protein that plays a crucial role in regulating the immune response and inflammation. It is a negative regulator of the JAK/STAT signaling pathway, which is involved in the signaling of various cytokines and growth factors.

Research has shown that SOCS-3 is often downregulated or inactivated in various types of cancer, including breast, lung, colon, and liver cancer. This downregulation can lead to an overactivation of the JAK/STAT pathway, resulting in the promotion of cell proliferation, survival, and angiogenesis (the formation of new blood vessels).
Scientific Papers found: Click to Expand⟱
5507- Ba,    Baicalein Enhances Radiosensitivity in Colorectal Cancer via JAK2/STAT3 Pathway Inhibition
- vitro+vivo, Var, NA
RadioS↑, p‑STAT3↓, JAK2↓, PD-L1↓, SOCS-3↑,
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8131- LF,    Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
- in-vitro, OS, HSC2 - in-vitro, OS, HSC3 - in-vitro, OS, HSC4 - in-vitro, Nor, RT7
P53↑, Akt↓, SOCS-3↑, mTOR↓, JAK↓, STAT3↓, selectivity↑, TumCP↓, Iron↓, TumCCA↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   Iron↓, 1,   PAO↑, 1,   ROS↓, 1,   ROS↑, 3,   SOD↓, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑GSK‐3β↓, 1,   HK2↓, 1,   SSAT↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   mt-Cyt‑c↓, 1,   IAP1↓, 1,   Mcl-1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   p‑Akt↓, 1,   JAK↓, 1,   JAK1↑, 1,   JAK2↓, 1,   mTOR↓, 1,   p‑p42↓, 1,   PI3K↓, 2,   PIAS-3↑, 1,   PTEN↑, 1,   Raf↓, 1,   RAS↓, 1,   Src↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO4↓, 1,   miR-21↓, 1,   PAX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   P53↑, 2,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EIF4E↓, 1,   p‑STAT1↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   EMT↓, 2,   MMP2↓, 2,   MMP9↓, 1,   N-cadherin↓, 1,   p‑p44↓, 1,   TumCMig↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   HIF-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   MCT1↓, 1,   NF-kB↓, 1,   PD-L1↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 3,   SOCS1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cachexia↓, 1,   Risk↓, 1,  
Total Targets: 88

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   MDA↓, 1,   ROS↓, 2,   SOD↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ICAM-1↓, 1,   IL1β↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiDiabetic↑, 1,   AntiTum↓, 1,   cardioP↑, 1,   cognitive↑, 1,   Learn↑, 1,   memory↑, 1,   neuroP↑, 1,   Stroke↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,  
Total Targets: 29

Scientific Paper Hit Count for: SOCS-3, Suppressor of Cytokine Signaling 3
1 Baicalein
1 Curcumin
1 Kaempferol
1 Lactoferrin/Talactoferrin
1 Matrine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:663  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page