γH2AX Cancer Research Results

γH2AX, gamma-H2AX: Click to Expand ⟱
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γH2AX (gamma-H2AX) is a histone protein that plays a crucial role in the repair of DNA double-strand breaks (DSBs). It is a phosphorylated form of the H2AX protein, which is a component of chromatin.

γH2AX is often used as a biomarker for DNA damage and genomic instability. When DNA is damaged, the H2AX protein is phosphorylated, forming γH2AX, which recruits and activates DNA repair proteins to the site of damage.
γ-H2AX, a marker for DNA double-strand breaks.

Cancer cells often exhibit increased levels of γH2AX due to their high rate of DNA replication and repair errors.

Gamma-H2AX, on the other hand, refers to a phosphorylated form of H2AX.
Scientific Papers found: Click to Expand⟱
5432- AG,    Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies
- Review, Cerv, NA
ChemoSen↑, eff↑, RadioS↑, CEA↓, Wnt↓, β-catenin/ZEB1↓, γH2AX↑, ER Stress↑, mt-TumAuto↑, QoL↑, Imm↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, Synergy↑,
4406- AgNPs,    Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,
9225- AITC,    Allyl Isothiocyanate Induces DNA Damage and Impairs DNA Repair in Human Breast Cancer MCF-7 Cells
- in-vitro, BC, MCF7
tumCV↓, Apoptosis↑, DNAdam↑, P53↑, p‑ATM↑, p‑γH2AX↑, BRCA1↑, PARP↑,
234- AL,    Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
- in-vitro, HCC, Hep3B
ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,
591- Api,  doxoR,    Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines
- in-vitro, AML, Jurkat - in-vitro, AML, THP1
ATP↓, Casp3↑, γH2AX↑,
1365- Ash,    Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells
- in-vitro, Oral, Ca9-22 - in-vitro, Oral, CAL27
ROS↑, *toxicity↓, Apoptosis↑, TumCCA↑, MMP↓, p‑γH2AX↑, DNAdam↑, eff↓,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2/PTGS2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, Synergy↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, Synergy↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, Synergy↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
1520- Ba,    Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, TOV-21G
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, Chk2↑, Dose∅, p‑γH2AX↑, CDC25↓, CHK1↓, cycD1/CCND1↓, eff↓, 12LOX↓,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
6504- BCP,    β-Caryophyllene Induces PPARγ-Mediated Apoptosis and Enhances the Radiosensitivity in Colorectal Cancer Cells
- in-vitro, CRC, CT26 - in-vitro, CRC, HCT116
RadioS↑, TumCCA↑, γH2AX↑, DNAdam↑, p‑Akt↓, cycD1/CCND1↓, PPARγ↑, Bax:Bcl2↑, Casp3↑, Apoptosis↑,
9208- BITC,    Benzyl Isothiocyanate-Induced DNA Damage Causes G2/M Cell Cycle Arrest and Apoptosis in Human Pancreatic Cancer Cells
- in-vitro, PC, Capan-2
p‑γH2AX↑, TumCD↑, TumCCA↑, P21↑, cycD1/CCND1↓, CDC2↓, CDC25↓, DNAdam↑,
5869- CA,    Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
- in-vitro, ESCC, KYSE150
TumCP↓, Apoptosis↓, TumCMig↓, TumCCA↑, DNAdam↑, MAPK↓, γH2AX↑, TumMeta↓, TumCI↓, P21↑, ROS↑, EMT↓, ChemoSen↑,
5828- CAP,    Capsaicin: a novel radio-sensitizing agent for prostate cancer
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
RadioS↑, NF-kB↓, TumCCA↑, TumCG↓, TumCP↓, DNAdam↑, γH2AX↑, Ki-67↓,
7167- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, YAP/TEAD↑, ATM↑, JNK↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCP↓, TrxR↓, Trx1↓, H3K9↓, p‑ATM↑, γH2AX↑, ALDOB↑, ENO3↑, FBP1↑, GSK‐3β↑, HK3↑, PCK1↑, PGK2↑, PGM1↑, PGM3↑, PHKG1↑, PKLR↑, HK2↓, PCNA↓,
474- CUR,    Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,
426- CUR,    Use of cancer chemopreventive phytochemicals as antineoplastic agents
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, CAL51
Bcl-2↓, ROS↑, BAX↑, RAD51↑, γH2AX↑,
454- CUR,    Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway
- in-vitro, GC, MGC803
TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,
6682- DCA,  QC,    Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer
- in-vivo, HNSCC, MEER
PDK1 / PDPK1↓, lactateProd↓, GlucoseCon↓, tumCV↓, mTOR↓, Apoptosis↑, ROS↑, TumCG↓, pH↑, cl‑PARP↑, Casp3↑, DNAdam↑, p‑γH2AX↑, eff↓, OS↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, Synergy↑, ROS↑, PDK1 / PDPK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
3236- EGCG,  Buty,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
6848- EVO,    Evodiamine: A Extremely Potential Drug Development Candidate of Alkaloids from Evodia rutaecarpa
- Review, Nor, NA
AntiTum↑, cardioP↑, Inflam↓, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, BioAv↓, toxicity↑, NF-kB↓, MAPK↓, NOD1↓, p‑Akt↓, BAX↑, cl‑Casp3↑, γH2AX↑, cl‑PARP↑, ROS↑, BBB↑, neuroP↑, BioAv↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
6900- FIS,    Fisetin targets phosphatidylinositol-3-kinase and induces apoptosis of human B lymphoma Raji cells
- in-vitro, lymphoma, NA
PI3K↓, Apoptosis↑, IAP2/BIRC3↓, mTOR↓, γH2AX↑, DNAdam↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
8601- FSO,    Differential Response of Two Human Breast Cancer Cell Lines to the Phenolic Extract from Flaxseed Oil
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF-10AT
TumCP↓, Apoptosis↑, TumCCA↑, lipid-P↑, γH2AX↑, eff↝, cl‑PARP1↑,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓, *antiAll↑,
1657- HCAs,    Anticancer Activity of Sinapic Acid by Inducing Apoptosis in HT-29 Human Colon Cancer Cell Line 2023
- in-vitro, CRC, HT-29
cl‑Casp3↑, BAX↑, cl‑PARP↑, γH2AX↑, Cyt‑c↑,
4644- HT,    The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells
- in-vitro, Melanoma, NA
tumCV↓, Apoptosis↑, P53↑, γH2AX↑, Akt↓, ROS↑, DNAdam↑,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
9180- ITCs,  SFN,    Epigenetics/epigenomics and prevention of early stages of cancer by isothiocyanates Review
- Review, Var, NA
HDAC↓, DNMT1↓, DNMT3B↓, BioAv↑, chemoPv↑, NRF2↑, HO-1↑, NQO1↑, GSK‐3β↓, β-catenin/ZEB1↓, EMT↓, ac‑H3↑, ac‑H4↑, Wnt↓, HDAC3↓, p‑γH2AX↑, hTERT/TERT↓, NA↑, cMyc↓, HDAC2↓, HDAC3↓, KLF4↓, TumVol↓, Dose?,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8243- LCA,    Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,
8276- LE,  Cisplatin,    Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis
- in-vitro, NSCLC, NA
tumCV↓, ChemoSen↑, Apoptosis↑, TumCCA↑, Bcl-xL↑, cl‑Casp↑, γH2AX↑, P53↑,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
8420- Lyco,    Anticancer activity of lycopene in HT-29 colon cancer cell line
- in-vitro, CRC, HT-29
Risk↓, Dose↝, TumCP↓, Casp3↑, BAX↑, cl‑PARP↑, 8-oxo-dG↑, γH2AX↑, Cyt‑c↑,
8542- Matr,    Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, p‑PI3K↓, CHK1↓, p‑Akt↓, Bcl-2↓, MTA1↓, Vim↓, MMP2↓, MMP9↓, γH2AX↑, E-cadherin↑, BAX↑, cl‑Casp3↑, Ki-67↓, TumCG↓,
8630- MBZ,  Rad,    Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism
- in-vitro, GBM, GL261 - in-vitro, GBM, GBM14
RadioS↑, γH2AX↑, eff↑, mitA↑,
488- MF,    Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells
- in-vitro, Var, HeLa - in-vitro, NA, IMR90
DNAdam↑, p‑γH2AX↑, Chk2↑, p38↑, Apoptosis↑,
9268- MFrot,    EXTH-13. Inhibition of mitochondrial electron transport, induction of oxidative stress, and DNA damage by oncomagnetic device in GBM cancer cells
- Review, GBM, NA
TumVol↓, OS↑, DNAdam↑, γH2AX↑, toxicity↓, compI↓, ROS↑, selectivity↑, TumCCA↑, eff↓,
2258- MFrot,  MF,    EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE
- in-vitro, GBM, GBM - in-vitro, Nor, SVGp12
TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,
8662- MLT,    Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis
- vitro+vivo, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, HNSCC, UM-SCC-1
Glycolysis↓, ENO1↓, ROS↑, TumCP↓, TumMeta↓, TumCCA↑, Casp3↑, BIM↑, Bcl-2↓, γH2AX↑, EMT↓, N-cadherin↓, MMP9↓, Snail↓, Akt↓, eff↓, TumVol↓, PPARγ↓,
8867- MOR,  doxoR,    Morin Sensitizes MDA-MB-231 Triple-Negative Breast Cancer Cells to Doxorubicin Cytotoxicity by Suppressing FOXM1 and Attenuating EGFR/STAT3 Signaling Pathways
- in-vitro, BC, MDA-MB-231
ChemoSen↑, EPR↑, DNAdam↑, γH2AX↑, p‑EGFR↓, p‑STAT3↓, TumCCA↑, P21↑, cycD1/CCND1↓, FOXM1↓, tumCV↓, *p38↑,

Showing Research Papers: 1 to 50 of 65
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 65

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↓, 2,   Catalase↑, 1,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 2,   GSH↑, 1,   GSR↑, 2,   HO-1↑, 3,   lipid-P↑, 4,   NQO1↑, 2,   NRF2↑, 3,   ROS↓, 3,   ROS↑, 38,   i-ROS↓, 1,   SOD↓, 3,   SOD↑, 1,   TAC?, 1,   Trx↑, 1,   Trx1↓, 1,   TrxR↓, 1,   TrxR↑, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 4,   CDC25↝, 1,   compI↓, 2,   compIII↓, 1,   EGF↓, 1,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 2,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 1,   p‑PDH↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   ALAT↓, 1,   ALDOB↑, 1,   ATP↓, 5,   ENO1↓, 1,   ENO3↑, 1,   FBP1↑, 1,   GlucoseCon↓, 3,   Glycolysis↓, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   HK2↓, 1,   HK3↑, 1,   lactateProd↓, 3,   LDHA↓, 1,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↑, 1,   PDK1 / PDPK1↓, 3,   PDKs↓, 1,   PGK2↑, 1,   PGM1↑, 1,   PGM3↑, 1,   PKLR↑, 1,   PKM2↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 31,   BAD↑, 1,   Bak↑, 2,   BAX↓, 2,   BAX↑, 12,   Bax:Bcl2↑, 5,   Bcl-2↓, 12,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BID↑, 1,   p‑BID↓, 1,   BIM↑, 2,   Casp↑, 4,   cl‑Casp↑, 1,   Casp3↑, 14,   cl‑Casp3↑, 11,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 7,   cl‑Casp9↑, 6,   Cyt‑c↑, 9,   Diablo↑, 1,   DR5↑, 3,   Fas↑, 2,   Ferroptosis↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   Mcl-1↓, 2,   p‑Mcl-1↓, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 2,   p38↑, 3,   PUMA↑, 1,   survivin↓, 7,   TumCD↑, 6,   XIAP↓, 2,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   p‑Akt↓, 6,   CK2↓, 1,   EGFR↓, 3,   p‑EGFR↓, 1,   ERK↓, 5,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 1,   JAK↓, 1,   JAK1↓, 1,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 5,   PDGFR-BB↓, 1,   PHKG1↑, 1,   PI3K↓, 6,   p‑PI3K↓, 1,   PTEN↑, 2,   Sp1/3/4↓, 1,   STAT3↓, 6,   p‑STAT3↓, 2,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 1,   cMyc↓, 4,   DNMT1↓, 2,   DNMT3B↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO3↑, 1,   H3↑, 1,   ac‑H3↑, 3,   H3K9↓, 1,   ac‑H4↑, 2,   HDAC↓, 3,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 2,   HMTs↓, 1,   KLF4↓, 1,   Myc↓, 1,   OCT4↓, 2,   other↓, 1,   other↝, 3,   OV6↓, 1,   SOX2↓, 1,   SOX4↓, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   ER Stress↑, 3,   HSP90↓, 1,   SERPINH1/HSP47↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   TumAuto↑, 4,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↑, 3,   p‑ATM↑, 2,   ATR↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DNA-PK↑, 2,   DNAdam↓, 2,   DNAdam↑, 34,   hTERT/TERT↓, 1,   MGMT↓, 1,   P53↓, 2,   P53↑, 14,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↑, 4,   cl‑PARP↑, 12,   cl‑PARP1↑, 2,   PCNA↓, 5,   RAD51↓, 1,   RAD51↑, 1,   TOP2↓, 1,   γH2AX↓, 1,   γH2AX↑, 50,   γH2AX↝, 1,   p‑γH2AX↑, 11,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↝, 1,   CDK2↓, 3,   CDK4↓, 4,   p‑CDK4↓, 1,   CDK6↓, 1,   cellSen↑, 1,   CHK1↓, 4,   CHK1↑, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 9,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 3,   cycE/CCNE↝, 1,   GADD45A↑, 1,   Ki-67↓, 6,   mitA↑, 2,   P21↓, 1,   P21↑, 15,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 34,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 2,   CSCs↓, 6,   FGF↓, 1,   Gli1↓, 2,   HH↓, 1,   Ki-67↓, 6,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH⇅, 1,   NOTCH1↓, 1,   NOTCH2↓, 1,   NOTCH2↑, 1,   PTCH1↓, 2,   Smo↓, 2,   TumCG↓, 11,   TumCG↑, 1,   TumCP↓, 20,   tyrosinase↓, 1,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 5,   EMT↓, 7,   EMT↑, 1,   EpCAM↓, 1,   GLI2↓, 1,   IQGAP3↓, 1,   MMP2↓, 11,   MMP9↓, 11,   MMPs↓, 1,   MTA1↓, 1,   N-cadherin↓, 5,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 5,   TIMP1↑, 2,   TIMP2↑, 1,   TumCA↑, 1,   TumCI↓, 6,   TumCMig↓, 12,   TumMeta↓, 6,   TumMeta↑, 1,   uPA↓, 1,   Vim↓, 6,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   CD31/PECAM-1↓, 1,   Hif1a↓, 2,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   EPR↑, 1,   GLUT1↓, 1,   MMP↓, 14,   SVCT-2∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 7,   CXCR2↑, 1,   DR4↑, 1,   IL1↑, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 2,   NF-kB↓, 9,   NF-kB↑, 1,   NOD1↓, 1,   p65↓, 1,   PGE2↓, 2,   PSA↓, 1,   TNF-α↓, 3,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER-α36↓, 2,   PPARγ↓, 1,   PPARγ↑, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 4,   ChemoSen↑, 17,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↝, 8,   Dose∅, 2,   eff↓, 13,   eff↑, 9,   eff↝, 1,   GSTA1↑, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   RadioS↑, 11,   selectivity?, 1,   selectivity↑, 10,   selectivity↝, 1,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 2,   AST↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   p‑EGFR↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Myc↓, 1,   PSA↓, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   neuroP↑, 1,   NKG2D↑, 1,   OS↑, 4,   Pin1↓, 1,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 2,   toxicity↑, 1,   TumVol↓, 6,   TumW↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 373

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   Prx↑, 1,   ROS↓, 3,   ROS∅, 1,   SOD↑, 2,   SOD2↑, 2,   TBARS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp3?, 1,   Casp3↓, 1,   Casp9↓, 1,   p38↑, 1,   p‑p38↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   Dose↝, 2,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiCan↑, 1,   cardioP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   Obesity↓, 1,   Stress↓, 1,   toxicity↓, 5,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 43

Scientific Paper Hit Count for: γH2AX, gamma-H2AX
4 Quercetin
4 Sulforaphane (mainly Broccoli)
3 doxorubicin
3 Ashwagandha(Withaferin A)
3 Curcumin
3 Resveratrol
2 Silver-NanoParticles
2 Radiotherapy/Radiation
2 Allyl isothiocyanate
2 Baicalein
2 Benzyl isothiocyanate
2 Dichloroacetate
2 Fisetin
2 Isothiocyanates
2 Kaempferol
2 Lycopene
2 Magnetic Fields
2 Magnetic Field Rotating
2 salinomycin
1 Astragalus
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Berberine
1 Beta-Caryophyllene
1 Carnosic acid
1 Capsaicin
1 chaetocin
1 Metformin
1 EGCG (Epigallocatechin Gallate)
1 Butyrate
1 Evodiamine
1 Ferulic acid
1 Formononetin
1 Flaxseed Oil
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 isoorientin
1 Phenethyl isothiocyanate
1 Juglone
1 Licochalcone A
1 Licorice
1 Cisplatin
1 Luteolin
1 Matrine
1 mebendazole
1 Melatonin
1 Morin
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Phycocyanin
1 Aflavin-3,3′-digallate
1 Thymoquinone
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:667  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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