LDL Cancer Research Results

LDL, LDL-cholesterol: Click to Expand ⟱
Source:
Type:
The relationship between LDL (low-density lipoprotein) cholesterol and cancer is a complex and evolving area of research. LDL cholesterol is often referred to as "bad" cholesterol because high levels are associated with an increased risk of cardiovascular diseases.

Protumorigenic: High levels of LDL cholesterol can promote tumor growth by providing lipids that are essential for cell membrane synthesis and energy production. Additionally, LDL can influence inflammation and angiogenesis, further supporting tumor development.
Antitumorigenic: Some studies suggest that lowering LDL cholesterol through lifestyle changes or medications (like statins) may have a protective effect against certain cancers, although the evidence is not uniform across all cancer types.
Scientific Papers found: Click to Expand⟱
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
5354- AL,    Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation
- Review, Var, NA
*LDL↓, *antiOx↑, AntiCan↑, *cardioP↑, *BP↓, *Weight↓, NK cell↑, *AntiDiabetic↑, *GSH↑,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓,
236- AL,    Allicin: Chemistry and Biological Properties
- Analysis, NA, NA
GSH↓, Bacteria↓, LDL↓, ROS↑, NRF2↑, cognitive↑, memory↑, BP↓, RNS↓,
7397- Amla,    Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study
- Trial, Nor, NA
*Dose↝, *other↑, *LDL↓, *HDL↑, *toxicity↑, *ROS↓,
7409- Amla,    Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study
- Trial, Nor, NA
*HDL↑, *LDL↓, *ROS↓, *AntiAg↑, *TBARS↓, *Dose↝,
7401- Amla,    The impact of Emblica Officinalis (Amla) on lipid profile, glucose, and C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
- Review, Nor, NA
*CRP↓, *glucose↓, *LDL↓, Dose↑,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
5445- ATV,    Atorvastatin
- NA, Nor, NA
*cardioP↑, *LDL↓, HMG-CoA↓, Half-Life↝, BioAv↓, Dose↝,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,
5571- B-Gluc,  immuno,    Potential benefit of β-glucans as adjuvant therapy in immuno-oncology: a review
- Review, Var, NA
Imm↑, ChemoSen↑, LDL↑, GutMicro↑, TumCP↓, Apoptosis↑, angioG↓, QoL↑,
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
*AChE↓, *Aβ↓, *LDL↓, *RenoP↑, *BChE↓, *eff↑, *BACE↓, *AChE↓, *eff↑,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
5510- bemA,    Combined inhibition of ACLY and CDK4/6 reduces cancer cell growth and invasion
- in-vitro, BC, MDA-MB-231 - in-vitro, PC, NA
eff↑, Apoptosis↑, TumCI↓, ACLY↓, LDL↓, eff↑, TumCP↓,
5509- bemA,    Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
- Review, Nor, NA
LDL↓, AMPK↑, ACLY↓,
5511- bemA,    Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation
- in-vitro, Var, NA
ACLY↓, PD-L1↑, mtDam↑, cGAS–STING↑, LDL↓, eff↑,
5514- bemA,    Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
- Trial, Nor, NA
*ACLY↓, *LDL↓, *MusCon↓, Dose↝, cardioP↑,
5708- Brut,    Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers
- Review, Nor, NA
*Imm↑, *cardioP↑, *LDL↓, toxicity↓,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑,
4476- Chit,    Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
- Trial, NA, NA
*LDL↓,
4475- Chit,    Cholesterol-lowering properties and safety of chitosan
- Review, Nor, NA
*Weight↝, *LDL↓,
6086- CHOC,    Cocoa and Chocolate in Human Health and Disease
- Review, Var, NA
*antiOx↑, *AntiDiabetic↑, *cognitive↑, *AntiAg↑, *AntiAg↑, *LDL↓, *HDL↑, *BP↓, *eff↓, *ROS↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
7406- Chy,    Antiamnesic activity of an ayurvedic formulation chyawanprash in mice
- in-vivo, AD, NA
*Dose↝, *memory↑, *TBARS↓, *GSH↑, *ROS↓, *cognitive↑, *AntiAge↑, *hepatoP↑, *antiOx↑, *LDL↓, *Inflam↓, *other↝, *AChE∅,
6169- Cin,    Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, IBD, NA
*neuroP↑, *AntiDiabetic↑, *tau↓, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *MDA↓, *GSH↓, *cardioP↑, *LDL↓, *HDL↑, *other↝, *TNF-α↓, *IL6↓, *MPO↓, *TLR4↓, *GutMicro↑, *lipid-P↓, *Wound Healing↑,
3892- Cin,    Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *cardioP↑, angioG↓, VEGF↓, *LDL↓, COX2↓, Hif1a↓, *Aβ↓, *tau↓, *toxicity↓,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
7421- CS,    Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial
- Trial, Nor, NA
*hepatoP↑, *Dose↝, *toxicity↓, *BloodF↑, *ALAT↓, *AST↓, *Bil↓, *LDL↓, *HDL↓, *TG/TAG↓,
7420- CS,    Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial
- Trial, Obesity, NA
*LDL↓, *HDL↑, Dose↝,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
7422- CS,    Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
- Review, Nor, NA
*LDL↓, *TG/TAG↓, *HDL∅,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
6715- dietF,    Are Fermented Foods Effective against Inflammatory Diseases?
- Review, Nor, NA
*Imm↑, *GastroP↑, *Inflam↓, AntiCan↑, *AntiBio↑, *hepatoP↑, *CD4+↑, *IFN-γ↓, *IL17↓, *GutMicro↑, *antiOx↑, *AST↓, *ALAT↓, *HDL↑, *LDL↓, *ROS↓, *lipid-P↓, *Inflam↓, *Aβ↓,
6716- dietF,    Current Research in Fermented Foods: Bridging Tradition and Science
- Review, Nor, NA
*GutMicro↑, *Inflam↓, *BP↓, *LDL↓, *HDL↑, *CRP↓, *IL6↓, *TNF-α↓, *Obesity↓, *AntiDiabetic↑, *cardioP↑, *GutMicro↑, *neuroP↑, *cognitive↑,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
4254- EA,    Chronic administration of ellagic acid improved the cognition in middle-aged overweight men
- Human, Obesity, NA
*LDL↓, *HDL↑, *BDNF↑, *cognitive↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *eff↑, *BioAv↑, eff↑, ChemoSen↑, *toxicity↝,
5784- EGCG,    Dietary Epicatechin Promotes Survival of Obese Diabetic Mice and Drosophila melanogaster
- in-vivo, Nor, NA
*OS↑, *Inflam↓, *LDL↓, *AntiAge↑, *GSH↑, *SOD↑, *AMPKα↑, *Weight∅,
7104- GEN,    Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial
- Trial, Pca, NA
Dose↝, PSA↓, *LDL↓,
2464- GI,    The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *LDL↓, *AntiAg↑, *AntiAg∅,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
7358- HibSad,    Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
- Review, Var, NA
chemoPv↑, *ROS↓, *other↝, *hepatoP↑, *lipid-P↓, Apoptosis↑, *LDL↓, RAS↓, Akt↓, NF-kB↓, Rho↝, MMPs↓, *AntiDiabetic↑, *Catalase↑, *GSH↑,
7361- HibSad,    Hibiscus sabdariffa L. - a phytochemical and pharmacological review
- Review, Var, NA
*Bacteria↓, *hepatoP↑, *diuretic↑, *LDL↓, *antiOx↑, *ACE↓, *Ca+2↝, *toxicity↓, *ROS↓, *RenoP↑,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
1791- LEC,    Vegetable lecithins: A review of their compositional diversity, impact on lipid metabolism and potential in cardiometabolic disease prevention
- Review, Nor, NA
*BioEnh↑, *antiOx↑, *BioEnh↑, *LDL↓, *HDL∅, *Obesity↓, eff↑, GutMicro↝,
1796- LEC,    A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin
- Review, NA, NA
BioAv↑, antiOx↑, LDL↓, memory↑,

Showing Research Papers: 1 to 50 of 71
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 71

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↓, 1,   HO-1↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NRF2↓, 2,   NRF2↑, 1,   OXPHOS↑, 1,   RNS↓, 1,   ROS↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   MMP↓, 2,   MMP↑, 2,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 3,   ALAT↓, 1,   AMPK↑, 2,   glucose↓, 1,   GLUT2↓, 1,   HK2↓, 1,   HMG-CoA↓, 2,   lactateProd↓, 1,   LDH↓, 1,   LDL↓, 9,   LDL↑, 1,   PDK1↓, 1,   PPARα↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 9,   BAD↑, 2,   Bak↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 1,   Casp3↑, 5,   Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 3,   Casp9↑, 2,   Cyt‑c↑, 1,   Fas↑, 2,   hTERT/TERT↓, 1,   iNOS↓, 1,   Mcl-1↓, 1,   Myc↓, 1,   p27↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

miR-25-5p↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3B↑, 1,   LC3II↑, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   P53↑, 1,   PARP↑, 3,   cl‑PARP↑, 1,   PCNA↓, 1,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   ERK↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC3↓, 1,   HMGCR↓, 2,   IGF-1↓, 2,   IGF-1R↑, 1,   mTOR↓, 2,   mTORC1↓, 1,   NOTCH1↑, 1,   NOTCH3↓, 1,   PI3K↓, 1,   PTEN↑, 1,   RAS↓, 3,   STAT↓, 1,   STAT3↓, 2,   TOP1↓, 1,   TumCG↓, 3,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CLDN1↓, 1,   E-cadherin↑, 1,   Fibronectin↓, 1,   MMP-10↓, 1,   MMP2↓, 2,   MMP9↓, 1,   MMPs↓, 1,   Rho↝, 1,   Slug↓, 1,   Smad1↓, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 5,   TumMeta↓, 1,   Twist↓, 1,   Vim↓, 1,   Zeb1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 2,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   COX2↑, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 3,   Inflam↓, 1,   JAK1↓, 1,   NF-kB↓, 2,   NK cell↑, 1,   PD-L1↑, 1,   PGE2↓, 1,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

cGAS–STING↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   ChemoSen↑, 6,   Dose↑, 1,   Dose↝, 4,   eff↑, 10,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   BP↓, 1,   EGFR↓, 2,   GutMicro↑, 1,   GutMicro↝, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   LDH↓, 1,   Myc↓, 1,   PD-L1↑, 1,   PSA↓, 1,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   cardioP↑, 3,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   memory↑, 2,   neuroP↑, 1,   OS↑, 1,   QoL↑, 3,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 3,   Risk↑, 1,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 179

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE↓, 1,   AntiBio↑, 4,   diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 22,   Bil↓, 1,   Catalase↑, 6,   GPx↑, 5,   GPx1↑, 1,   GSH↓, 1,   GSH↑, 9,   HDL↓, 1,   HDL↑, 11,   HDL∅, 2,   HO-1↑, 3,   HO-2↓, 1,   lipid-P↓, 8,   MDA↓, 4,   MPO↓, 3,   NQO1↑, 1,   NRF2↑, 4,   RNS↓, 1,   ROS↓, 19,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 8,   TBARS↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   adiP↓, 1,   ALAT↓, 2,   AMPK↑, 1,   glucose↓, 3,   HMG-CoA↓, 1,   LDL↓, 40,   NADPH↓, 2,   PPARα↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   BAX↓, 2,   Bcl-2↑, 1,   Cyt‑c↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↓, 2,   other↑, 4,   other↝, 4,   other∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,   GSK‐3β↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 3,   PI3K↑, 1,   PTEN↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AntiAg∅, 1,   Ca+2?, 1,   Ca+2↝, 1,   CDK5↓, 1,   MUC1↑, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 4,   TXA2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 2,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2↓, 4,   CRP↓, 5,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 5,   IL23↓, 1,   IL6↓, 6,   Imm↑, 2,   Inflam↓, 20,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   TLR4↓, 2,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   AChE∅, 1,   BChE↓, 2,   BDNF↑, 3,   ChAT↑, 1,   MAOA↓, 1,   tau↓, 3,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 8,   BACE↓, 2,   MAOB↓, 1,   NLRP3↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   BioEnh↑, 2,   Dose↝, 10,   eff↓, 4,   eff↑, 6,   eff↝, 1,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 3,   Bil↓, 1,   BloodF↑, 1,   BP↓, 7,   CRP↓, 5,   Ferritin↑, 1,   GutMicro↑, 7,   IL6↓, 6,   TG/TAG↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   AntiCan↑, 1,   AntiDiabetic↑, 9,   BOLD↑, 1,   cardioP↑, 14,   cognitive↑, 10,   hepatoP↑, 7,   memory↑, 10,   motorD↑, 1,   MusCon↓, 1,   neuroP↑, 13,   Obesity↓, 3,   OS↑, 3,   QoL↑, 2,   RenoP↑, 3,   Risk↓, 3,   toxicity↓, 5,   toxicity↑, 1,   toxicity↝, 1,   Weight↓, 1,   Weight↝, 1,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   Sepsis↓, 1,  
Total Targets: 149

Scientific Paper Hit Count for: LDL, LDL-cholesterol
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Atorvastatin
4 EGCG (Epigallocatechin Gallate)
4 bempedoic acid
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Lycopene
3 Allicin (mainly Garlic)
3 Curcumin
3 Hibiscus sabdariffa
3 Vitamin B5,Pantothenic Acid
2 Berberine
2 chitosan
2 Cinnamon
2 diet Fermented Foods
2 diet Short Term Fasting
2 Lecithin
1 Anthocyanins
1 beta-glucans
1 immunotherapy
1 Huperzine A/Huperzia serrata
1 Bruteridin(bergamot juice)
1 Carvacrol
1 Chocolate
1 Chrysin
1 Chyawanprash
1 Coenzyme Q10
1 Selenium
1 Ellagic acid
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 Metformin
1 Naringin
1 Nimbolide
1 Phenylbutyrate
1 Pterostilbene
1 Quercetin
1 Resveratrol
1 Salvia officinalis
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 Thymoquinone
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:71  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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