EIF4E Cancer Research Results

EIF4E, eukaryotic translation initiation factor 4E: Click to Expand ⟱
Source:
Type: protein
EIF4E: a protein that plays a crucial role in the regulation of protein synthesis, particularly in the translation of mRNAs involved in cell growth, proliferation, and survival.
EIF4E overexpressed in: breast, lung, colon, and prostate cancer.
Scientific Papers found: Click to Expand⟱
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, Beclin-1/ATG6↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
452- CUR,    Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells
- vitro+vivo, HNSCC, SCC9 - vitro+vivo, HNSCC, FaDu - vitro+vivo, HNSCC, HaCaT
TumCCA↑, PI3k/Akt/mTOR↓, Casp3↑, EGFR↓, EGF↑, PRKCG↑, p‑Akt↓, p‑mTOR↓, RPS6KA1↓, EIF4E↓, proCasp3↓,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 3,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↑, 1,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑GSK‐3β↓, 1,   HK2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 4,   BAX↑, 2,   Bcl-2↓, 1,   Casp3↑, 2,   proCasp3↓, 1,   mt-Cyt‑c↓, 1,   IAP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   EGFR↓, 1,   p‑mTOR↓, 1,   PI3K↓, 2,   PI3k/Akt/mTOR↓, 1,   PRKCG↑, 1,   RPS6KA1↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO4↓, 1,   PAX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EIF4E↓, 5,   mTORC1↓, 3,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCMig↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 3,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cachexia↓, 1,   toxicity↝, 1,  
Total Targets: 63

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ICAM-1↓, 1,   IL1β↓, 1,   NF-kB↓, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   cognitive↑, 1,   Learn↑, 1,   memory↑, 1,   Stroke↓, 1,  
Total Targets: 21

Scientific Paper Hit Count for: EIF4E, eukaryotic translation initiation factor 4E
3 borneol
1 Radiotherapy/Radiation
1 Curcumin
1 Matrine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:716  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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