VGCC Cancer Research Results

VGCC, Voltage-gated calcium channels: Click to Expand ⟱
Source:
Type: transmembrane proteins
VGCCs play a crucial role in various cellular processes, including cell signaling, proliferation, and differentiation.
VGCCs are transmembrane proteins that regulate the influx of calcium ions into cells. Calcium ions act as a second messenger, triggering various signaling pathways that control cell growth, survival, and migration. In cancer cells, VGCCs can be overexpressed or mutated, leading to aberrant calcium signaling and contributing to tumor growth and metastasis.
Overexpressed in: breast cancer, prostate cancer, colorectal cancer, glioblastoma Associated with: tumor growth, metastasis, and poor prognosis.
Scientific Papers found: Click to Expand⟱
5525- EP,    Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs)
- Review, Var, NA
CellMemb↑, Ca+2↑, ER Stress↑, ROS↑, MMP↓, VGCC↓, VGSC↓, Dose↝,
5530- EP,    Expression of voltage-gated calcium channels augments cell susceptibility to membrane disruption by nanosecond pulsed electric field
- in-vitro, Nor, HEK293
*CellMemb↑, *VGCC↑, *Ca+2↑, *MMP↓, *VGCC⇅, eff↑,
5520- EP,    Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora’s Box
- Review, Var, NA
Ca+2↑, Apoptosis↑, Diff↑, TumCP↓, Wound Healing↑, CellMemb↑, VGCC↑, VGSC↑, DNAdam↑, selectivity↑,
2238- MF,    Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects
- Review, Var, NA
*BMD↑, *VGCC↑, *Ca+2↑, *NO↑, *eff↓,
499- MF,    The Effect of Pulsed Electromagnetic Fields on Angiogenesis
- Review, NA, NA
angioG↑, VEGF↑, VGCC↑,
3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Ca+2↓, *neuroP↑, *other↑, *Dose↝, *PKCδ↓, *VGCC↓, *GABA↑,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   VGCC↓, 1,   VGCC↑, 2,   VGSC↓, 1,   VGSC↑, 1,  

Migration ⓘ

Ca+2↑, 2,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

Wound Healing↑, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

VGCC↓, 1,   VGCC↑, 2,   VGCC⇅, 1,  

Migration ⓘ

Ca+2↓, 1,   Ca+2↑, 2,   PKCδ↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

GABA↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 17

Scientific Paper Hit Count for: VGCC, Voltage-gated calcium channels
3 Electrical Pulses
2 Magnetic Fields
1 Taurine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:758  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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