miR-34b-5p Cancer Research Results

miR-34b-5p, miR-34b-5p: Click to Expand ⟱
Source:
Type: tumor suppressor miRNA
miR-34b-5p is downregulated in several types of cancer: CRC, breast, lung, prostate. The tumor suppressor function of miR-34b-5p is thought to be mediated by its ability to target and downregulate genes involved in cell proliferation, survival, and metastasis. Some of the target genes of miR-34b-5p include:

• BCL-2: an anti-apoptotic protein that promotes cell survival.
• CCND1: a cyclin-dependent kinase that promotes cell cycle progression.
• VEGF: a vascular endothelial growth factor that promotes angiogenesis (the formation of new blood vessels).
Scientific Papers found: Click to Expand⟱
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, *ALP↑, *RUNX2↑, *BMP2↑, *OCN↑, *OPN↑, *β-catenin/ZEB1↑, *STAC2↑, *Diff↑, *BMD↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↓, 1,   NRF2↓, 1,   ROS↑, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   G6PD↓, 1,   GLS↓, 1,   GlutaM↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PKM2↓, 1,   PPP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   Mcl-1?, 1,   MDM2↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   PI3K↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 2,   FOXO3↑, 1,   HES1↓, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-206↑, 1,   miR-21↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-326-5p↑, 1,   miR-34b-5p↑, 2,   miR-384↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 1,   NOTCH↓, 1,  

Migration(tgid=13) ⓘ

EMT↓, 1,   MMP16↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 2,   VEGF↓, 1,   VEGFR1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  
Total Targets: 59

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics(tgid=7) ⓘ

miR-34b-5p↓, 1,   RUNX2↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,  

Migration(tgid=13) ⓘ

OPN↑, 1,   STAC2↑, 1,   β-catenin/ZEB1↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↑, 1,   BMD↑, 1,   OCN↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: miR-34b-5p, miR-34b-5p
1 Licorice
1 Luteolin
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:775  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page