CREB Cancer Research Results

CREB, cAMP Response Element Binding Protein: Click to Expand ⟱
Source:
Type: transcription factor
CREB is a transcription factor that binds to specific DNA sequences, known as cAMP response elements (CRE), in the promoter regions of target genes.
CREB is activated by phosphorylation, which allows it to bind to CRE and recruit other transcriptional coactivators.
CREB regulates the expression of genes involved in various cellular processes, including:
    Cell growth and differentiation
    Apoptosis
    Metabolism
    Neurotransmission

CREB is also involved in the regulation of genes involved in cancer, including:
    Cell cycle progression
    Angiogenesis
    Invasion and metastasis

CREB is often overexpressed in cancer tissues.
High levels of CREB expression are associated with poor prognosis, increased tumor aggressiveness, and resistance to therapy. CREB can promote the expression of genes involved in cell survival and proliferation.
Scientific Papers found: Click to Expand⟱
279- ALA,    Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Furin↓, IGF-1R↓, ROS↑, CREB↓, Furin↓, IGF-1R↓,
3884- Api,    Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *antiOx↑, *BDNF↑, *p‑CREB↑, *p‑ERK↑, *ROS↓, *SOD↑, *GPx↑, *neuroP↑,
3887- Api,    The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *Aβ↓, *memory↑, *AChE↓, *Ach↑, *Dose↑, *BDNF↑, *TrkB↑, *p‑CREB↑, *BBB↑, *Ca+2?,
4279- Api,    The Beneficial Role of Apigenin against Cognitive and Neurobehavioural Dysfunction: A Systematic Review of Preclinical Investigations
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *5HT↑, *CREB↑, *BDNF↑, *memory↑, *motorD↑, *Mood↑, *cognitive↑, *ROS↓,
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, AML, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, AD, NA
*IL1β↓, *IL6↓, *TNF-α↓, *CRP↓, *CREB↑, *BDNF↑,
6507- BCP,    Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation
- Review, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *TLR4↓, *NF-kB↓, *NLRP3↓, *MAPK↓, *NRF2↑, *HO-1↑, *PI3K↑, *Akt↑, *cAMP↑, *PKA↑, *CREB↑,
9171- BITC,    Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
p‑P53↑, Apoptosis↑, cl‑PARP↑, Ki-67↓, survivin↓, XIAP↓, p‑ERK↑, p‑CREB↑, MDM2↑,
4277- BM,    Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical, Bacopa Monnieri
- in-vivo, AD, NA
*BDNF↑, *p‑CREB↑,
4269- Bos,    Boswellia serrata gum resin aqueous extract upregulates BDNF but not CREB expression in adult male rat hippocampus
- in-vivo, AD, NA
*BDNF↑, *CREB∅,
5761- CAPE,    Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of AMPK and Akt signaling networks
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCCA↑, AMPK↓, NF-kB↓, β-catenin/ZEB1↓, CREB↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓,
3875- Carno,    Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro
- in-vitro, AD, NA
*IronCh↑, *CREB↑, *BDNF↑, *NGF↑, *antiOx↑, *ROS↓,
4260- CHr,    Chrysin modulates the BDNF/TrkB/AKT/Creb neuroplasticity signaling pathway: Acting in the improvement of cognitive flexibility and declarative, working and aversive memory deficits caused by hypothyroidism in C57BL/6 female mice
- in-vivo, AD, NA
*BDNF↑, *TrkB↑, *Akt↑, *CREB↑, *memory↑, *cognitive↑,
4208- Cro,    Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus
- in-vivo, AD, NA
*BDNF↑, *CREB↑, *p‑CREB↑,
4158- Cro,    Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus
- in-vivo, AD, NA
*CREB↑, *BDNF↑, *Mood↑,
4176- CUR,    Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling
- in-vivo, AD, NA
*BDNF↑, *CREB↑,
4171- CUR,    Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons
- in-vivo, Nor, NA
*BDNF↑, *TrkB↑, *CREB↑, *Mood↑, *neuroP↑,
4178- DHA,    The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma
- in-vivo, AD, NA
*BDNF↑, *CREB↑, *cognitive↑, *SOD↑,
4177- DHA,    Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats
- in-vivo, AD, NA
*BDNF↑, *CREB↑, *ROS↓, *cognitive↑,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp/ABCB1↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE/β-secretase↓, *LC3II↓, *Beclin-1/ATG6↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
4250- Flav,    Dietary Flavonoids Interaction with CREB-BDNF Pathway: An 
Unconventional Approach for Comprehensive Management of Epilepsy
- Review, AD, NA
*ERK↑, *BDNF↑, *CREB↑,
4245- GBE,    Standardized extract of Ginkgo biloba enhances memory persistence over time
- in-vivo, AD, NA
*memory↑, *BDNF↑, *CREB↓, *BDNF↑,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE/β-secretase↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4003- Gins,    Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences
- Review, adrenal, NA
*neuroP↑, *Inflam↓, *ROS↓, *BACE/β-secretase↓, *PPARγ↑, *Aβ↓, *p‑tau↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓, *CREB↓, *BDNF↑, *memory↑,
4235- H2,    PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression
- in-vivo, Sepsis, NA
*PPARα↑, *CREB↑, *BDNF↑, *OS↑, *cognitive↑,
4241- HNK,    Effects of Honokiol on Neurological Injury and Cognitive Function in Mice with Intracerebral Hemorrhage by Regulating BDNF-TrkB-CREB Signaling Pathway
- in-vivo, Stroke, NA
*Apoptosis↓, *cognitive↑, *BDNF↑, *TrkB↑, *CREB↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
7879- isoO,    Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex
- in-vivo, AD, NA
*cognitive↑, *AChE↓, *TBARS↓, *SOD↑, *p‑CREB↑, *BDNF↑, *memory↑, *cognitive↑,
7870- isoO,    Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway
- vitro+vivo, AD, PC12
*GSK‐3β↓, *BAX↓, *Casp3↓, *cl‑Casp3↓, *Bcl-2↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *p‑Akt↑, *p‑GSK‐3β↑, *NRF2↑, *p‑CREB↑, *BDNF⇅,
7827- KAE,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *Learn↑, *memory↑, *antiOx↑, *Inflam↓, *Aβ↓, *cognitive↑, *BDNF↑, *TrkB↑, *CREB↑, *ERβ/ESR2↑, *ERK↑, *ROS↓, *AChE↓, *Dose↑,
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,
8311- lign,    The Power of Lignans: Plant Compounds with Multifaceted Health-Promoting Effects
- Review, Nor, NA
*cardioP↑, *AntiDiabetic↑, *Obesity↓, *Bacteria↓, *AntiFungal↑, *AntiViral↑, *neuroP↑, *antiOx↑, *lipid-P↓, *memory↑, *CREB↑, *BDNF↑, *PSD95↑, *β-Amyloid↓, *TNF-α↓, *IL6↓, *IL10↓, *GutMicro↑, *Endoglin↑, *END↑, *cognitive↑, *Akt↓, *IκB↓, *NF-kB↓, *HO-1↑, *VEGF↑, *p‑eNOS↑, *GRP78/BiP↓, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *SREBP1/SREBF1↓, *ROS↓, TumVol↓,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *Synergy↑,
8493- MAG,    Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway
- in-vitro, AD, SH-SY5Y
*neuroP↑, *Aβ↓, *p‑tau↓, *Apoptosis↓, *CHRM1↑, *cAMP↑, *PKA↑, *CREB↑,
4147- MF,    PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration
- in-vitro, AD, PC12
*ROS↓, *Catalase↑, *MMP↑, *Casp3↓, *p‑ERK↓, *cAMP↑, *p‑CREB↑, *BDNF↑, *neuroP↑,
8456- Mg,    Magnesium-L-threonate Ameliorates Cognitive Deficit by Attenuating Adult Hippocampal Neurogenesis Impairment in a Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*neuroG↑, *memory↑, *p‑ERK↑, *p‑CREB↑, *CREB↓, *ERK↓, *cognitive↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8681- MLT,    Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
HIF-1↓, G6PD↓, GAPDH↓, PDH↓, CS↓, PFK1↓, LDH↓, PDH↑, lactateProd↓, glut↓, CREB↓, JNK↓, NF-kB↓, p38↓, ERK↓, Akt↓, P70S6K↓, STAT↓, Warburg↓, GlutaM↓,
8908- MO,    Water Extracts of Moringa oleifera Leaves Alter Oxidative Stress-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells
- in-vitro, AD, SH-SY5Y
*antiOx↑, *ROS↓, *GPx↑, *Catalase↑, *SOD↑, *Bcl-2↓, *BAX↓, *Casp3↓, *BDNF↑, *p‑Akt↑, *p‑CREB↑, *neuroP↑,
8959- mushLions,  BM,  L-THE,    Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
- Review, AD, NA
*Synergy↑, *neuroP↑, *INF-γ↑, *BDNF↑, *Synergy↑, *Synergy↑, *BBB↑, *Ki-67↑, *p‑CREB↑, *tau↓, *GSK‐3β↓, *Wnt↑, *β-catenin/ZEB1↑, *memory↑, *Sleep↑, *p‑NF-kB↓, *ROS↓, *Stress↓,
5604- NaHCO3,    Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, 4T1
eff↑, eff↑, TumMeta↓, pH↑, CaMKII ↑, CREB↑, PGC-1α↑, AntiTum↑, Imm↑, CD8+↑, TAMS↑,
4224- NarG,    The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model
- in-vivo, Obesity, NA - NA, AD, NA
*memory↑, *Mood↑, *CREB↑, *BDNF↑, *AChE↓, *cognitive↑, *neuroP↑,
4156- PB,    The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain
- in-vivo, AD, NA
*BDNF↑, *CREB↑,
5210- PI,    Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells
- in-vitro, Melanoma, B16-BL6
IL1β↓, TNF-α↓, MMPs↓, p65↓, p50↓, NF-kB↓, ATF2↓, cFos↓, CREB↓,
1016- PI,    Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
β-catenin/ZEB1↓, Wnt↓, TumCP↓, TumCMig↓, *antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *Bacteria↓, *memory↑, AntiCan↑, NF-kB↓, cFos↓, ATF2↓, CREB↓,
7517- Poly,    Modulation of neurotrophic signaling pathways by polyphenols
- Review, Nor, NA
*NRF2↑, *HO-1↑, *NGF↑, *BDNF↑, *neuroP↑, p‑CREB↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3922- PTS,    Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway
- in-vivo, AD, NA
*BioAv↑, *BBB↑, *memory↑, *p‑CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,

Showing Research Papers: 1 to 50 of 60
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 60

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   H2O2↑, 1,   MDA↓, 1,   ROS↓, 1,   ROS↑, 3,   ROS⇅, 1,   SOD↓, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CS↓, 1,   mtDam↑, 1,   PDH↓, 1,   PDH↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   AMPK↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   glut↓, 1,   GlutaM↓, 1,   lactateProd↓, 1,   PFK1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 4,   BAX↑, 2,   Bcl-2↓, 1,   Casp3↑, 4,   Casp7↑, 1,   Casp9↑, 1,   CellShr↑, 1,   Cyt‑c↑, 3,   Diablo↑, 1,   FADD↑, 1,   MDM2↑, 1,   MOMP↑, 1,   p38↓, 1,   p‑p38↓, 1,   survivin↓, 1,   TNFR 1↑, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   CaMKII ↑, 2,   CREB↓, 6,   CREB↑, 1,   p‑CREB↓, 2,   p‑CREB↑, 2,   EGFR↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   JNK↓, 1,   mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 3,   PTEN↑, 2,   p‑RSK↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   STAT↓, 1,   p‑STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF2↓, 3,   H3↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   p‑CDK2↓, 1,   CDK4↓, 1,   p‑Chk2↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   Ki-67↓, 2,   Securin↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 2,   Ki-67↓, 2,   TumCG↓, 6,   TumCP↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   Furin↓, 2,   MMP1↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 2,   MMPs↓, 1,   Slug↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   HIF-1↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD8+↑, 1,   COX2/PTGS2↓, 2,   ICAM-1↓, 1,   IL1β↓, 1,   Imm↑, 2,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   p50↓, 1,   p65↓, 1,   PGE2↓, 1,   PSA↓, 1,   SOCS1↑, 1,   TCF↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TNF-α↓, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   TAMS↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 2,   Dose↝, 2,   eff↑, 2,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   Synergy?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 2,   Remission↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 155

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 15,   Catalase↑, 5,   GPx↑, 8,   GSH↑, 6,   GSR↑, 2,   H2O2↓, 2,   HNE↓, 1,   HO-1↑, 7,   Iron↓, 1,   lipid-P↓, 5,   MDA↓, 4,   Nrf1↑, 1,   NRF2↑, 7,   ROS↓, 24,   SOD↓, 1,   SOD↑, 13,   TAC↑, 1,   TBARS↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↓, 1,   IronCh↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   AMPK↑, 1,   ATP↑, 1,   cAMP↑, 3,   GSK‐3β↓, 5,   p‑GSK‐3β↑, 1,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 4,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 3,   Casp3↓, 6,   cl‑Casp3↓, 1,   Casp9↑, 1,   iNOS↓, 1,   iNOS↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↑, 2,   CREB↓, 3,   CREB↑, 31,   CREB∅, 1,   p‑CREB↑, 16,   ERK↓, 1,   ERK↑, 9,   p‑ERK↓, 1,   p‑ERK↑, 2,   IκB↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   PI3K↑, 2,   PKA↑, 5,   PKCδ↑, 1,   PP2A↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC↓, 1,   HDAC2↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↑, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   Ki-67↑, 1,   neuroG↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

Ca+2?, 1,   Ca+2↓, 1,   MMP9↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,   p‑eNOS↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL1β↓, 5,   IL33↓, 1,   IL6↓, 7,   IL8↓, 1,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 13,   NeuroI↓, 3,   NF-kB↓, 7,   p‑NF-kB↓, 2,   NLRP3↓, 4,   TLR3↓, 1,   TLR4↓, 1,   TNF-α↓, 6,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 3,   AChE↓, 8,   ADAM10↑, 1,   BDNF↑, 41,   BDNF⇅, 1,   BDNF∅, 1,   ChAT↑, 2,   CHRM1↑, 1,   GABA↑, 1,   NGF↑, 2,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 1,   TrkB↑, 8,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 2,   Aβ↓, 12,   Aβ↑, 1,   BACE/β-secretase↓, 8,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 4,   p‑tau↓, 7,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

END↑, 1,   ERβ/ESR2↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 3,   Dose↑, 2,   eff↑, 1,   Half-Life↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 7,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   cognitive↑, 23,   hepatoP↑, 2,   Learn↑, 2,   memory↑, 26,   Mood↑, 4,   motorD↑, 1,   neuroP↑, 26,   Obesity↓, 1,   OS↑, 1,   Sleep↑, 2,   Stress↓, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 1,  
Total Targets: 177

Scientific Paper Hit Count for: CREB, cAMP Response Element Binding Protein
3 Apigenin (mainly Parsley)
2 Bacopa monnieri
2 Crocetin
2 Curcumin
2 Docosahexaenoic Acid
2 Ginseng
2 isoorientin
2 Melatonin
2 Piperine
2 Pterostilbene
2 Resveratrol
2 Thymoquinone
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Berberine
1 Beta-Caryophyllene
1 Benzyl isothiocyanate
1 Boswellia (frankincense)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Chrysin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Zinc
1 Emodin
1 Fisetin
1 flavonoids
1 Ginkgo biloba
1 Hydrogen Gas
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Kaempferol
1 Mung Bean Sprouts
1 Lapachol
1 SDG/lignans
1 Luteolin
1 Magnolol
1 Magnetic Fields
1 Magnesium
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 L-Theanine
1 Bicarbonate(Sodium)
1 Naringin
1 Phenylbutyrate
1 Polyphenols
1 Quercetin
1 Salvia officinalis
1 Rosmarinic acid
1 Aromatherapy
1 Sulforaphane (mainly Broccoli)
1 Spirulina(Arthrospira/Limnospira)
1 Safflower yellow
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:798  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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