GAPDH Cancer Research Results

GAPDH, Glyceraldehyde-3-phosphate dehydrogenase: Click to Expand ⟱
Source:
Type: gene
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a housekeeping gene that encodes a protein involved in glycolysis, a metabolic pathway that converts glucose into energy. GAPDH is a crucial enzyme in the glycolytic pathway, and its expression is often used as a control gene in molecular biology experiments.
GAPDH has been shown to be overexpressed in various types of tumors, including breast, lung, colon, and prostate cancer.
Cancer cells often exhibit increased glycolysis, even in the presence of oxygen, a phenomenon known as the Warburg effect. GAPDH overexpression can contribute to this increased glycolysis.
Scientific Papers found: Click to Expand⟱
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,
5257- 3BP,    Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- Review, Var, NA
Glycolysis↓, mt-OXPHOS↓, HK2↓, Cyt‑c↑, Casp3↓, Bcl-2↓, Mcl-1↓, GAPDH↓, LDH↓, PDH↓, TCA↓, GlutaM↓, GSH↓, ATP↓, mitResp↓, ROS↑, ChemoSen↑, toxicity↝,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
8702- CAP,    Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy
- Review, Var, NA
Apoptosis↑, TumCMig↓, Synergy↑, ROS↑, RNS↑, selectivity↑, TumCG↓, TumVol↓, OS↑, E-cadherin↑, ChemoSen↑, Ingr↝, eff↓, angioG↓, TumMeta↓, EMT↓, TumCCA↑, Glycolysis↓, HK2↓, PFK1↓, LDH↓, GLUT2↓, PI3K↓, Akt↓, GAPDH↓, CSCs↓, ChemoSen↑,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, lactateProd↓, ECAR↓, NO↓, ROS↑, HK2↓, PFK1↓, GAPDH↓, PKM2↓, LDHA↓, FASN↓, GLUT1↓, MCT1↓, MCT4↓, HCAR1↓, SDH↑, ChemoSen↑, ROS↑, BioAv↑, P53↑, NF-kB↓, pH↑,
694- EGCG,    Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways
- in-vitro, BC, MCF7
Glycolysis↓, GAPDH↓, ROS↑, OCR↓, ECAR↓, mTOR↓, OXPHOS↓,
2178- itraC,    Itraconazole inhibits tumor growth via CEBPB-mediated glycolysis in colorectal cancer
- in-vivo, CRC, HCT116
TumCG↓, Glycolysis↓, CEBPB?, ENO1↓, LDHA↓, PKM2↓, GAPDH↓, ECAR↓, OCR↓,
1890- MGO,    The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches
- Review, Var, NA
AntiCan?, TumCG↓, GAPDH↓, Apoptosis↑, TumCCA↑, MAPK↑, Bcl-2↓, MMP9↓, ChemoSen↑,
8670- MLT,    Antitumor Effects of Melatonin in Luminal and Triple-Negative Breast Cancer Cells: Metabolic Reprogramming, Redox Regulation, and Cellular Dynamics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, TumCMig↓, TumCI↓, GAPDH↓, Hif1a↓, citrate↓, ROS↑, lipid-P↑, LDH↓, G6PD↓, MDA?, Catalase↓, GPx↑, GSH↑, *ROS↓,
8681- MLT,    Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
HIF-1↓, G6PD↓, GAPDH↓, PDH↓, CS↓, PFK1↓, LDH↓, PDH↑, lactateProd↓, glut↓, CREB↓, JNK↓, NF-kB↓, p38↓, ERK↓, Akt↓, P70S6K↓, STAT↓, Warburg↓, GlutaM↓,
992- PL,    Piperlongumine based nanomedicine impairs glycolytic metabolism in triple negative breast cancer stem cells through modulation of GAPDH & FBP1
- in-vivo, BC, NA
EPR↓, Glycolysis↓, GAPDH↓, GSTP1/GSTπ↝, FBPase↑,
627- VitC,    High-Dose Vitamin C for Cancer Therapy
- Review, Var, NA
ROS↑, PARP↑, GAPDH↓, DNAdam↑, ATP↓,

Showing Research Papers: 1 to 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GPx↑, 1,   GSH↓, 3,   GSH↑, 1,   lipid-P↑, 1,   MDA?, 1,   RNS↑, 1,   ROS↑, 8,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CS↓, 1,   mitResp↓, 1,   mtDam↑, 1,   OCR↓, 2,   OXPHOS↓, 1,   mt-OXPHOS↓, 2,   PDH↓, 2,   PDH↑, 1,   SDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 4,   citrate↓, 1,   ECAR↓, 4,   ENO1↓, 1,   FASN↓, 1,   FBPase↑, 1,   G6PD↓, 2,   GAPDH↓, 13,   GlucoseCon↓, 1,   glut↓, 1,   GlutaM↓, 2,   Glycolysis↓, 7,   HK2↓, 4,   lactateProd↓, 2,   LDHA↓, 2,   MCT4↓, 1,   PFK1↓, 3,   PKM2↓, 2,   PPP↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bcl-2↓, 3,   Casp3↓, 1,   Casp3↑, 1,   Cyt‑c↑, 2,   Mcl-1↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   CREB↓, 1,   ERK↓, 1,   JNK↓, 1,   MAPK↑, 1,   mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   HDAC↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PARP↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPB?, 1,   CSCs↓, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   MMP9↓, 2,   TumCA↑, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   HIF-1↓, 1,   Hif1a↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

EPR↓, 1,   GLUT1↓, 1,   GLUT2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HCAR1↓, 1,   Inflam↓, 1,   MCT1↓, 1,   NF-kB↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 6,   Dose↝, 1,   eff↓, 1,   eff↑, 2,   GSTP1/GSTπ↝, 1,   RadioS↑, 1,   selectivity↑, 3,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan?, 1,   OS↑, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 106

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 1,   HO-1↑, 1,   NOX4↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GAPDH↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Cyt‑c↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  
Total Targets: 16

Scientific Paper Hit Count for: GAPDH, Glyceraldehyde-3-phosphate dehydrogenase
4 3-bromopyruvate
2 Melatonin
1 Radiotherapy/Radiation
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Chrysin
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 itraconazole
1 Methylglyoxal
1 Piperlongumine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:812  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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