AntiCan Cancer Research Results

AntiCan, Anticancer Effect: Click to Expand ⟱
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Type: general indicator
Anticancer Effect


Scientific Papers found: Click to Expand⟱
6467- 1,8-Cin,    Evaluation of in vitro anticancer activity of 1,8-Cineole-containing n-hexane extract of Callistemon citrinus (Curtis) Skeels plant and its apoptotic potential
- in-vitro, Melanoma, A431 - in-vitro, OS, MG63 - in-vitro, Nor, HaCaT
TumCP↓, selectivity↑, AntiCan↑, TumCD↑, Apoptosis↑, Dose↝, ROS↑,
5275- 3BP,    3-Bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: Introduction to a special issue
- Review, Var, NA
AntiCan↑, HK2↓, OCR↓,
5273- 3BP,    The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view
- Review, Var, NA
AntiCan↑, ROS↑, angioG↓, CSCs↓, Warburg↓, GSH↓, Thiols↓,
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
5472- AF,    Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion
- in-vitro, Cerv, HeLa
TrxR↓, AntiCan↑, TumCG↓, Apoptosis↑, necrosis↑, cl‑PARP↑, MMP↓, ROS↑, GSH↓, eff↓,
5458- AF,    Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
- in-vitro, NSCLC, NA
TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5976- AgNPs,    Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions
- Review, Vit, NA
*Bacteria↓, AntiCan↑, *Inflam↓, *Wound Healing↑, Synergy↑, ChemoSen↑, EGFR↓, ROS↑, P53↑, BAX↑, Casp3↑, toxicity↝,
5978- AgNPs,    Biological synthesis of silver nanoparticles and their medical applications
- Review, Var, NA
Wound Healing↑, AntiCan↑, other↑, MPT↑, ROS↑, other↑, DNAdam↑,
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP/DDIT3↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
4560- AgNPs,    Exploiting antidiabetic activity of silver nanoparticles synthesized using Punica granatum leaves and anticancer potential against human liver cancer cells (HepG2)
- in-vitro, Liver, HepG2 - in-vitro, Diabetic, NA
AntiCan↑, Dose↝, *antiOx↑, *AntiDiabetic↑, *Bacteria↓,
4555- AgNPs,    Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2
*Bacteria↓, tumCV↓, selectivity↑, ROS↑, Apoptosis↑, TumCMig↓, AntiCan↑,
4552- AgNPs,  ART/DHA,    Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS)
- in-vitro, GC, AGS
AntiCan↑, Apoptosis↑, eff↑,
4548- AgNPs,  Chit,    Synergistic combination of antioxidants, silver nanoparticles and chitosan in a nanoparticle based formulation: Characterization and cytotoxic effect on MCF-7 breast cancer cell lines
- in-vitro, BC, MCF7
AntiCan↑, EPR↑, pH↝,
4542- AgNPs,    Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity─A 2024 Update
- Review, Var, NA
AntiCan↑, DNAdam↑, ATP↓, Apoptosis↑, ROS↓, TumCCA↑, *Bacteria↓, *BMD↑,
4539- AgNPs,  VitC,  Citrate,    Investigating the Anti-cancer Potential of Silver Nanoparticles Synthesized by Chemical Reduction of AgNO3 Using Trisodium Citrate and Ascorbic Acid
- in-vitro, Nor, L929 - in-vitro, Ovarian, SKOV3
AntiCan↑,
4584- AgNPs,    Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells
- in-vitro, Pca, DU145
selectivity↑, ROS↑, BAX↑, cl‑Casp3↑, p‑PARP↑, TumCCA↑, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, AntiCan↑,
4396- AgNPs,    Identification of possible reductants in the aqueous leaf extract of mangrove plant Rhizophora apiculata for the fabrication and cytotoxicity of silver nanoparticles against human osteosarcoma MG-63 cells
- in-vitro, OS, MG63
AntiCan↑, tumCV↓,
4403- AgNPs,    Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, GL26 - in-vitro, Cerv, HeLa - in-vitro, CRC, RKO
AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,
4389- AgNPs,    Graphene Oxide-Silver Nanocomposite Enhances Cytotoxic and Apoptotic Potential of Salinomycin in Human Ovarian Cancer Stem Cells (OvCSCs): A Novel Approach for Cancer Therapy
- in-vitro, Ovarian, NA
tumCV↓, ROS↑, LDH↓, MMP↑, CSCs↓, AntiCan↑,
4384- AgNPs,    Silver nanoparticles: synthesis, properties, and therapeutic applications
- Review, Var, NA
AntiCan↑, RadioS↑, CellMemb↑, ROS↑, DNAdam↑, PhotoS↑, eff↑,
4422- AgNPs,    Bioengineering of Piper longum L. extract mediated silver nanoparticles and their potential biomedical applications
- in-vitro, Cerv, HeLa
AntiCan↑, selectivity↑,
4412- AgNPs,    Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties
- in-vitro, CRC, HCT116 - in-vitro, Melanoma, A2780S
Bacteria↓, antiOx↑, AntiCan↑, eff↑,
4411- AgNPs,    Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities
- in-vitro, Lung, A549 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,
4410- AgNPs,    Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy
- Review, Colon, NA
AntiCan↑, ROS↑, mtDam↑, tumCV↓, selectivity↑,
4431- AgNPs,  doxoR,    Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1 - in-vitro, Nor, 3T3
AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,
9220- AITC,    Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation
- in-vitro, Bladder, NA
TumCCA↑, mitA↑, Apoptosis↑, α-tubulin↓, Cyt‑c↑, Casp9↑, Casp3↑, JNK↑, AntiBio↑, AntiCan↑, BioAv↑,
5354- AL,    Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation
- Review, Var, NA
*LDL↓, *antiOx↑, AntiCan↑, *cardioP↑, *BP↓, *Weight↓, NK cell↑, *AntiDiabetic↑, *GSH↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2646- AL,    Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
- in-vitro, Pca, DU145 - in-vitro, Melanoma, RPMI-8226
AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
2666- AL,    Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
- Review, Var, NA
Inflam↓, AntiCan↑, ROS↑, MAPK↑, JNK↑, TumAuto↑, other↑, Dose↝, MALAT1↓, Wnt↓, β-catenin/ZEB1↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7402- Amla,    Traditional knowledge to clinical trials: A review on therapeutic actions of Emblica officinalis
- Review, Var, NA
*Synergy↑, *antiOx↑, *AntiCan↑, *Imm↑, *Inflam↓, *AntiArt↑, *Dose↝, *VitC↑, radioP↑, *cardioP↑, *GastroP↑, *Wound Healing↑, *Diar↓, eff↑, NK cell↑, BAX↑, Bcl-2↓, TumCCA↑, Dose↝,
6393- ANE,    Anethole in cancer therapy: Mechanisms, synergistic potential, and clinical challenges
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCCA↑, TumCP↓, angioG↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, Casp↓, ChemoSen↑,
6397- ANE,  Cisplatin,    Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways
- in-vitro, SCC, Ca9-22
AntiCan↑, ChemoSen↑, TumCP↓, MMP↓, ROS↑, MAPK↓, β-catenin/ZEB1↓, NF-kB↓, EMT↓, Casp↑,
1546- Api,    Apigenin in Cancer Prevention and Therapy: A Systematic Review and Meta-Analysis of Animal Models
- Review, Var, NA
TumVol↓, TumW↓, AntiCan↑, Apoptosis↑, TumCCA↑,
1561- Api,    Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications
- in-vivo, Nor, JB6
*NRF2↑, *DNMT1↓, *DNMT3A↓, *HDAC↓, *AntiCan↑,
2636- Api,    Apigenin unveiled: an encyclopedic review of its preclinical and clinical insights
- Review, Nor, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *Inflam↓, *antiOx↑, *hepatoP↑, ChemoSen↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
5382- ART/DHA,    A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies
- Trial, Var, NA
AntiCan↑, Dose↝, Dose↝,
5378- ART/DHA,    Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives
- Review, Var, NA
Ferroptosis↑, Iron↑, lipid-P↑, MOMP↑, AntiCan↑, NCOA4↑, GSH↓, GPx4↓, ROS↑, ChemoSen↑, ER Stress↑, DNAdam↑, angioG↓, TumCCA↑, eff↓,
5377- ART/DHA,    Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein
- in-vitro, AML, NA
AntiCan↑, Ferroptosis↑, Iron↑, Mets↑, eff↑, GSH↝, Synergy↑, other↓, eff↑, other↓,
5395- Ash,    Withaferin A Targets Heat Shock Protein 90 in Pancreatic Cancer Cells
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCP↓, HSP90↓, Akt↓, CDK4↓, TumCG↓, Apoptosis↑, AntiCan↑,
5384- AsP,  MLT,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,

Showing Research Papers: 1 to 50 of 491
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 491

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 23,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 10,   GPx4↑, 1,   GSH↓, 24,   GSH↑, 3,   GSH↝, 1,   GSH∅, 1,   GSH/GSSG↓, 1,   GSTs↑, 4,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 5,   i-Iron↑, 3,   c-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 11,   MDA↓, 2,   MDA↑, 3,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 11,   NRF2↝, 1,   Prx↓, 2,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 25,   ROS↑, 167,   ROS⇅, 3,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   selenoP↓, 1,   SOD↓, 6,   SOD↑, 4,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 3,   Trx↓, 2,   TrxR↓, 4,   TrxR1↓, 3,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 4,   compI↓, 1,   compII↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC?, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   mtDam↑, 12,   OCR↓, 6,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↑, 2,   PDH↝, 1,   PHB↓, 1,   SIRT3↑, 1,   TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   AApath↓, 1,   ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   Alanine↓, 1,   ALAT↓, 2,   AMPK↑, 9,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 11,   i-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CRM↑, 1,   DHCR24↓, 1,   DHODH↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   GAPDH↓, 1,   glucose↓, 2,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   GlutMet↓, 1,   Glycine↓, 1,   Glycolysis↓, 14,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   H2S↑, 1,   Histones↑, 1,   HK2↓, 5,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 2,   lactateProd∅, 1,   LDHA↓, 3,   LDL↓, 1,   NAD↓, 1,   NADPH↓, 3,   NADPH↑, 2,   PDK1 / PDPK1↓, 2,   PDKs↓, 1,   PFK↓, 1,   PKM2↓, 8,   PLA2↓, 1,   polyA↓, 1,   SIRT1↓, 6,   SIRT1↑, 6,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 2,   Apoptosis↑, 182,   mt-Apoptosis↑, 2,   BAD↓, 3,   BAD↑, 5,   Bak↓, 1,   Bak↑, 7,   BAX↓, 1,   BAX↑, 71,   Bax:Bcl2↑, 15,   Bcl-2↓, 78,   Bcl-2↑, 1,   Bcl-xL↓, 11,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↑, 1,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 24,   Casp↝, 1,   Casp12↑, 2,   Casp12↝, 1,   Casp3↓, 3,   Casp3↑, 75,   cl‑Casp3↑, 15,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp7↑, 11,   cl‑Casp7↑, 2,   Casp8↑, 21,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 51,   p‑Casp9↑, 1,   cl‑Casp9↑, 5,   CellShr↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 51,   Diablo↑, 2,   DIDO1/DIO-1↑, 1,   DR5↑, 9,   FADD↑, 3,   Fas?, 1,   Fas↓, 2,   Fas↑, 12,   FasL↑, 5,   Ferroptosis↑, 10,   GRP58↓, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   IAP1↓, 3,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 4,   p‑Mcl-1↓, 1,   MDM2↓, 3,   MDM2↑, 1,   MOMP↑, 4,   Necroptosis↑, 3,   necrosis↑, 5,   p38↓, 2,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 2,   pS2/TFF1↓, 1,   PUMA↓, 1,   PUMA↑, 3,   Pyro↑, 2,   RIP3↓, 1,   survivin↓, 21,   TRAIL↑, 3,   TumCD↓, 1,   TumCD↑, 16,   XIAP↓, 13,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↑, 3,   p‑Akt↓, 17,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CIP2A↓, 2,   CK2↓, 2,   CREB↓, 1,   EGFR↓, 18,   EGFR↑, 1,   ERK↓, 33,   ERK↑, 4,   p‑ERK↓, 7,   FGFR1↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 10,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 8,   JAK3↓, 1,   JNK↓, 1,   JNK↑, 8,   p‑JNK↑, 3,   MAPK↓, 22,   MAPK↑, 11,   MARK4↓, 1,   MEK↓, 2,   MKP1↝, 1,   mTOR↓, 43,   p‑mTOR↓, 7,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 2,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 69,   PI3K↑, 2,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PI3K/Akt↑, 1,   PIK3CA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 7,   PKCδ↑, 1,   PTEN↓, 2,   PTEN↑, 10,   Raf↓, 1,   RAS↓, 6,   Rictor↓, 1,   RIP1↓, 1,   S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   Src↓, 1,   STAT↓, 2,   STAT3↓, 36,   STAT3↑, 3,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 1,   STK11/LKB1↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF2↓, 2,   ATF4↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 1,   cMyc↓, 16,   cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 1,   HDAC↓, 15,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 4,   miR-106b↓, 1,   miR-155↓, 1,   miR-199↓, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 4,   miR-590-3p↑, 1,   MTA2↓, 1,   Myc↓, 3,   OCT4↓, 6,   other↓, 5,   other↑, 5,   other↝, 18,   other∅, 1,   PCAF↓, 1,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 1,   SOX9↓, 1,   TLE1↓, 1,   tumCV?, 2,   tumCV↓, 41,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 7,   eIF2α↑, 1,   ER Stress↑, 22,   ERStress↑, 1,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HTRA↓, 1,   PERK↑, 1,   PSMB5↓, 1,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 10,   LC3s↑, 1,   p62↓, 4,   p62↑, 4,   TumAuto↓, 3,   TumAuto↑, 42,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 1,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↓, 3,   DNAdam↑, 49,   DNArepair↓, 1,   DNArepair↑, 2,   hTERT/TERT↓, 3,   p16↑, 2,   P53↓, 1,   P53↑, 42,   P53↝, 1,   p‑P53↓, 2,   p‑P53↑, 2,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 18,   Telomerase↓, 8,   TOP1↓, 7,   TOP2↓, 3,   TOP2↑, 1,   TP53↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↑, 1,   CDK2↓, 12,   CDK2↑, 2,   CDK4↓, 26,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 6,   CDKN1C/p57↓, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 2,   Chk2↑, 2,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 34,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 2,   E2Fs↓, 2,   GADD34↑, 1,   Ki-67↓, 12,   MAD↓, 1,   mitA↑, 1,   p19↑, 1,   P21↓, 4,   P21↑, 33,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 18,   pRB↓, 3,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 141,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 19,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 4,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 12,   IGFBP3↑, 1,   Ki-67↓, 12,   Let-7↑, 2,   LRP6↓, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH1↓, 7,   NOTCH3↓, 1,   p300↓, 2,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 68,   TumCG↑, 3,   TumCP↓, 110,   TumCP↑, 3,   Wnt↓, 22,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AP-1↓, 3,   AP-1↑, 1,   ATPase↓, 1,   CA↓, 1,   Ca+2↓, 2,   Ca+2↑, 17,   Ca+2↝, 2,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   CTNNB1↓, 1,   E-cadherin↑, 23,   EMT↓, 30,   EMT↑, 1,   EpCAM↓, 3,   FAK↓, 9,   FAK↑, 1,   p‑FAK↓, 2,   hnRNPA1↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP2↓, 44,   MMP3↓, 5,   MMP7↓, 3,   MMP9↓, 55,   MMP9↑, 1,   MMPs↓, 12,   MTA1↓, 1,   N-cadherin↓, 11,   NFAT↑, 1,   PAK1↓, 1,   PDGF↓, 3,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 2,   Smad1↓, 2,   SMAD4↓, 2,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 11,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 6,   TIMP2↓, 3,   TIMP2↑, 6,   TIMP3↑, 1,   TRIB3↑, 2,   TSP-1↑, 1,   TumCA↓, 5,   TumCI↓, 46,   TumCMig↓, 56,   TumCMig↑, 2,   TumMeta↓, 55,   TumMeta↑, 4,   Twist↓, 6,   TXNIP↑, 1,   uPA↓, 7,   uPAR↓, 1,   Vim↓, 13,   Zeb1↓, 5,   ZEB2↓, 2,   α-tubulin↓, 3,   β-catenin/ZEB1↓, 27,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 78,   angioG↑, 2,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 34,   LOX1↓, 2,   LymphAG↓, 1,   NO↓, 2,   PHDs↓, 1,   VEGF↓, 49,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 1,   BBB↑, 3,   CellMemb↓, 1,   CellMemb↑, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN7↑, 1,   EPR↑, 6,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   LAT↓, 1,   MMP↓, 73,   MMP↑, 3,   MPT↑, 3,   NHE1↓, 1,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↝, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CD14↓, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 6,   CD59↑, 1,   CD8+↑, 4,   p‑cDC2↓, 1,   COX2/PTGS2↓, 40,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL12↓, 1,   CXCR4↓, 5,   DCells↑, 1,   Dectin1↝, 1,   DR4↑, 4,   FOXP3↓, 1,   HCAR2↑, 2,   HMGB1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 3,   Igs↓, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 2,   IL12↑, 2,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 2,   IL5↓, 1,   IL6↓, 22,   IL8↓, 7,   Imm↑, 12,   Imm↝, 2,   INF-γ↓, 1,   INF-γ↑, 1,   Inflam↓, 36,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 79,   NF-kB↑, 5,   p‑NF-kB↓, 1,   NK cell↑, 10,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 1,   ac‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 10,   PSA↓, 11,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 2,   Th2↑, 1,   TLR4↓, 4,   TNF-α↓, 15,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   e-pH↑, 1,   i-pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN2/PS-2↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↓, 1,   AR↓, 7,   CYP19↓, 2,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   EstroRS/ERS↓, 1,   GR↑, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 5,   RANKL↓, 2,   SRC3↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 42,   BioAv⇅, 1,   BioAv↝, 10,   BioEnh↑, 3,   ChemoSen?, 1,   ChemoSen↓, 3,   ChemoSen↑, 124,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 2,   CompStab?, 1,   CompStab↑, 2,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 2,   CYP1A2↓, 2,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP2E1↑, 1,   CYP3A2↓, 1,   CYP3A4↓, 3,   Dose?, 5,   Dose↓, 1,   Dose↑, 6,   Dose↝, 47,   Dose∅, 11,   eff↓, 26,   eff↑, 75,   eff↝, 12,   eff∅, 3,   GSTM1↑, 1,   Half-Life↓, 7,   Half-Life↑, 1,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 13,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 28,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 65,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 67,   UGT1A↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   AR↓, 7,   ascitic↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   CIT↓, 1,   CRP↓, 2,   EGFR↓, 18,   EGFR↑, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   hTERT/TERT↓, 3,   IL6↓, 22,   LDH↓, 6,   LDH↑, 1,   LDH↝, 1,   Maspin↑, 1,   Myc↓, 3,   PD-L1↓, 5,   Polyps↓, 2,   PSA↓, 11,   PSA∅, 1,   TF-Ag↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 11,   AntiCan↑, 368,   AntiCan⇅, 2,   AntiCan↝, 1,   AntiCan?, 1,   AntiCan∅, 3,   AntiDiabetic↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 16,   APG↓, 1,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 10,   CardioT↓, 1,   chemoP↑, 31,   chemoPv↑, 23,   ChemoSideEff↓, 6,   cognitive↑, 1,   FTO↓, 1,   hepatoP↑, 9,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 9,   OS⇅, 1,   Pain↓, 4,   Pin1↓, 1,   QoL↑, 4,   radioP↑, 7,   Remission↑, 2,   RenoP↑, 4,   Risk↓, 30,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 18,   toxicity↑, 3,   toxicity⇅, 1,   toxicity↝, 9,   toxicity∅, 2,   TumNum↓, 1,   TumVol↓, 17,   TumW↓, 7,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiViral↑, 1,   Bacteria↓, 2,   Dectin1↝, 1,   GutMicro↑, 6,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 832

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 10,   antiOx↑, 150,   ARE↑, 1,   Catalase↑, 40,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 30,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 34,   GSR↑, 6,   GSTs↓, 1,   GSTs↑, 12,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HDL∅, 1,   HO-1↓, 1,   HO-1↑, 16,   HO-1⇅, 1,   hyperG↓, 2,   hyperG↝, 1,   Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   lipid-P↓, 33,   MDA↓, 26,   MDA↑, 2,   MPO↓, 5,   NOX↓, 1,   NQO1↑, 3,   NQO1↝, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 38,   Prx↑, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 109,   ROS↑, 2,   mt-ROS↓, 1,   SAM-e↑, 1,   selenoP↑, 4,   SOD↑, 50,   mt-SOD↑, 1,   SOD1↑, 6,   SOD2↑, 2,   TAC↑, 3,   TBARS↓, 3,   Trx↑, 1,   uricA↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 6,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   5LO↓, 3,   ACC↓, 1,   ACC↑, 1,   Acetyl-CoA↑, 1,   ALAT?, 1,   ALAT↓, 17,   ALAT∅, 1,   AMPK↓, 1,   AMPK↑, 7,   p‑AMPK↑, 2,   ATP↓, 1,   ATP↑, 4,   ATP↝, 1,   CRM↑, 2,   Eic↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↑, 3,   glyC↓, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 2,   LDL↓, 11,   lipidLev↓, 2,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   SIRT1↑, 4,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 7,   Apoptosis↑, 1,   BAX↓, 8,   Bcl-2↓, 2,   Bcl-2↑, 4,   Casp3↓, 10,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 5,   Cyt‑c↓, 2,   Fas↓, 1,   Ferroptosis↓, 2,   GSDMD↓, 1,   iNOS↓, 15,   iNOS↑, 1,   necrosis↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 4,   p‑Akt↓, 1,   Akt2↓, 1,   ERK↓, 2,   IGF-1R↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 2,   MAPK↓, 8,   MAPK↑, 2,   mTOR↓, 4,   mTOR↑, 1,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 4,   PI3K↑, 3,   PKCδ↑, 1,   PP2A↑, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 3,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   FOXO3↑, 1,   HATs↓, 2,   HDAC↓, 2,   HDAC2↓, 1,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 20,   PhotoS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 8,   DNArepair↑, 1,   P53↓, 3,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 1,   P21↓, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   BMPs↑, 1,   EP300↓, 1,   GH↑, 1,   HH↓, 1,   Ki-67↓, 1,   mTORC1↓, 1,   neuroG↑, 4,   TumCP↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 10,   AP-1↓, 4,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 3,   Ca+2∅, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 4,   PAI-1/SERPINE1↓, 1,   ROCK1↓, 1,   serineP↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP1↓, 1,   TumCI↓, 1,   Vim↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 2,   Hif1a↓, 1,   NO↓, 9,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 4,   BBB↑, 9,   GastroP↑, 4,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 2,   MMP↑, 7,   OCLN↝, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 3,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 25,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 4,   IL1?, 1,   IL1↓, 2,   IL10↓, 3,   IL10↑, 3,   IL12↓, 4,   IL17↓, 4,   IL1β↓, 19,   IL22↓, 1,   IL23↓, 1,   IL6?, 1,   IL6↓, 27,   IL6↑, 1,   IL8↓, 6,   Imm↓, 1,   Imm↑, 22,   Imm⇅, 2,   Imm↝, 2,   Inflam?, 1,   Inflam↓, 173,   Inflam↑, 4,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NF-kB?, 1,   NF-kB↓, 36,   NF-kB↑, 2,   NK cell↑, 2,   NLRP3↓, 3,   NLRP3↑, 1,   PGE2↓, 10,   PGE2↑, 1,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 40,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 1,   AChE↓, 17,   ADAM10↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 5,   ChAT↑, 2,   NGF↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APOE4↓, 1,   APP↓, 1,   cl‑APP↑, 1,   Aβ↓, 18,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   PSEN1/PS1↑, 1,   tau↓, 5,   p‑tau↓, 5,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   BNP↓, 1,   PPARγ↑, 2,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 35,   BioAv↑, 47,   BioAv⇅, 2,   BioAv↝, 22,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 21,   eff↑, 13,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↝, 10,   Half-Life∅, 1,   P450↓, 2,   P450↑, 1,   selectivity↑, 2,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 17,   ALAT∅, 1,   ALB↑, 1,   ALP↓, 2,   AST↓, 18,   AST∅, 1,   BG↓, 2,   BloodF↑, 2,   BMD↑, 4,   BP↓, 11,   BUN↓, 3,   Calcium↑, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 3,   HbA1c↓, 1,   HOMA↓, 1,   hs-CRP↓, 3,   IL6?, 1,   IL6↓, 27,   IL6↑, 1,   IRes↓, 1,   IRes↝, 1,   LDH↓, 6,   Mag↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 15,   antiAll?, 1,   antiAll↑, 14,   AntiArt↑, 13,   AntiCan?, 1,   AntiCan↓, 4,   AntiCan↑, 105,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 56,   antiM↑, 1,   antiPy↑, 1,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 64,   CardioT↓, 1,   chemoP↑, 9,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 25,   cough?, 1,   diuretic↑, 3,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 60,   Learn↑, 1,   memory↑, 24,   Mood↑, 2,   motorD↑, 4,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 98,   NP/CIPN↓, 1,   Obesity↓, 15,   OS↑, 3,   Pain↓, 4,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 14,   Risk↓, 1,   Sleep↑, 1,   SoreThr?, 1,   Stress↓, 1,   Stroke↓, 12,   Stroke↝, 1,   toxicity↓, 39,   toxicity↑, 3,   toxicity↝, 17,   toxicity∅, 6,   Weight↓, 4,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 29,   AntiFungal↓, 1,   AntiFungal↑, 11,   AntiP↑, 4,   AntiViral↑, 18,   Bacteria↓, 51,   Diar↓, 2,   GutMicro↑, 25,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 5,   Ingr↝, 14,   Phen↑, 1,   QC↑, 1,  
Total Targets: 442

Scientific Paper Hit Count for: AntiCan, Anticancer Effect
19 Silver-NanoParticles
12 Lycopene
11 Selenium NanoParticles
10 Thymoquinone
10 phytic acid, Inositol hexakisphosphate
9 Emodin
9 Inositol
9 Sulforaphane (mainly Broccoli)
8 Capsaicin
8 Magnolol
8 Phenethyl isothiocyanate
8 Quercetin
7 Allicin (mainly Garlic)
7 Curcumin
7 Gambogic Acid
7 Kaempferol
6 Vitamin C (Ascorbic Acid)
6 Astaxanthin
6 Baicalein
6 Eugenol
6 Honokiol
6 Isoliquiritigenin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Artemisinin
5 EGCG (Epigallocatechin Gallate)
5 Lactoferrin/Talactoferrin
4 chitosan
4 Apigenin (mainly Parsley)
4 Boron
4 Carvacrol
4 Chlorogenic acid
4 Crocetin
4 Dandelion Root
4 Ferulic acid
4 Isovitexin
4 Licochalcone A
4 Licorice
4 Naringin
4 Selenium
3 Cisplatin
3 Melatonin
3 Aloe anthraquinones
3 beta-glucans
3 Biochanin A
3 Benzyl isothiocyanate
3 α-Bisabolol / Chamomile oil
3 Hydroxycinnamic-acid
3 Resveratrol
3 Spermidine
3 Carvone
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Cucurbitacin
3 Date Fruit Extract
3 Diindolylmethane
3 Indole-3-carbinol
3 Lemongrass Extract/Citral
3 Ellagic acid
3 flavonoids
3 Formononetin
3 Flaxseed/Linseed
3 Fucoidan
3 Gallic acid
3 Garcinol
3 Geraniol
3 Ginkgetin
3 HydroxyTyrosol
3 Hyperoside
3 Isobavachalcone
3 Luteolin
3 Matrine
3 Mung Bean Sprouts
3 Propolis -bee glue
3 Pterostilbene
3 salinomycin
3 Silymarin (Milk Thistle) silibinin
3 Vitamin D3
3 Vitamin K2
2 3-bromopyruvate
2 5-fluorouracil
2 Auranofin
2 doxorubicin
2 Alpha-Lipoic-Acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Baicalin
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 Butyrate
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Chrysin
2 Cinnamon
2 Camptothecin
2 Dichloroacetate
2 diet Fermented Foods
2 Ginkgo biloba-EGb 761
2 Flaxseed Oil
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Hydrogen Gas
2 Hibiscus sabdariffa
2 iodine
2 isoquercitrin
2 Isothiocyanates
2 Ivermectin
2 Juglone
2 SDG/lignans
2 Vitexin
2 Magnetic Fields
2 Morin
2 Bicarbonate(Sodium)
2 Marjoram (Origanum majorana)
2 Purple Corn / Purple Maize
2 Phycocyanin
2 Piperine
2 Rosmarinic acid
2 Rauwolfia serpentina/Indian Snakeroot
2 Sesamin
2 Shikonin
2 Ursolic acid
2 Urolithin
2 VitK3,menadione
1 1,8-Cineole
1 Astragalus
1 Citric Acid
1 Allyl isothiocyanate
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Berberine
1 Betulinic acid
1 Bromelain
1 borneol
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Vitamin B3,Niacin
1 Caffeic acid
1 Caffeine
1 urea
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Carica papaya leaf extract
1 irinotecan
1 Cranberry
1 Calorie Restriction Mimetics
1 Aspirin
1 Polyphenols
1 Chlorella (Chlorella vulgaris)
1 Diclofenac
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 diet Plant based
1 Ormeloxifene (Centchroman)
1 Electrical Pulses
1 Eurycomanone
1 Evodiamine
1 ferumoxytol
1 Fisetin
1 Paclitaxel/Taxol
1 Gamma-aminobutyric acid
1 Ginkgo biloba
1 Geldanamycin
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 alpha Linolenic acid
1 Graviola
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Chemotherapy
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 isoorientin
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Lecithin
1 Linalool
1 Lutein
1 Methylene blue
1 Photodynamic Therapy
1 mebendazole
1 methylseleninic acid
1 Metformin
1 Magnetic Field Rotating
1 Mangiferin
1 Methylglyoxal
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Oleocanthal
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Psoralidin
1 Parthenolide
1 Gold NanoParticles
1 Salvia officinalis
1 Radiotherapy/Radiation
1 α-Santalol/Sandalwood oil
1 Calcium
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Magnesium
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:813  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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