OCR Cancer Research Results

OCR, Oxygen consumption rate: Click to Expand ⟱
Source:
Type:
Oxygen consumption rate (OCR) is a measure of the rate at which cells consume oxygen, and it has been found to be altered in cancer cells. Cancer cells often exhibit increased glycolysis, a process in which glucose is converted into energy without the use of oxygen, even in the presence of oxygen. This is known as the Warburg effect.
Cancer cells often exhibit increased glycolysis, which leads to a decrease in OCR.
-When mitochondrial function is impaired (resulting in lower OCR), cells may compensate by upregulating glycolysis to meet their energy needs (known as the Pasteur effect).
-Instruments such as the Seahorse Analyzer allow simultaneous measurement of OCR (reflecting mitochondrial respiration) and Extracellular Acidification Rate (ECAR, which is commonly used as a proxy for glycolysis). This dual measurement helps researchers understand how shifts in one pathway correlate with compensatory changes in the other.
Scientific Papers found: Click to Expand⟱
5275- 3BP,    3-Bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: Introduction to a special issue
- Review, Var, NA
AntiCan↑, HK2↓, OCR↓,
3453- 5-ALA,    The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis
- in-vitro, Lung, A549
OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,
5460- AF,    Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
- vitro+vivo, Var, 4T1
RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
6596- Anamu,    Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells
- in-vitro, AML, K562
TumCP↓, OCR↓, ATP↓, TumCCA↑, ECAR↑, Glycolysis↓, lactateProd↓, mitResp↓,
2389- BA,    Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor
- in-vitro, Obesity, 3T3
*ECAR↑, *OCR↓, *p‑AMPK↑, *p‑ACC↑, *Glycolysis↑, *lipidDe↓, *SREBP1↓, *FAO↑, *HK2↑, *PKM2↑, *LDHA↑, *PDKs↓, *ACC↓,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
*BioAv↓, *Half-Life↝, *OCR↓, *AMPK↑,
2733- BetA,    Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling
- in-vitro, Oral, KB - in-vivo, NA, NA
TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
943- BetA,    Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
Glycolysis↓, lactateProd↓, GlucoseCon↓, ECAR↓, cMyc↓, LDHA↓, p‑PDK1↓, PDK1↓, Cav1↑, *Glycolysis↑, selectivity↑, OCR↓, OXPHOS↓,
6544- BSB,    Involvement of mitochondrial permeability transition pore opening in alpha-bisabolol induced apoptosis
- in-vitro, GBM, NA
*Inflam↓, *AntiBio↑, selectivity↑, Apoptosis↑, Casp3↑, cl‑PARP↑, MMP↓, Cyt‑c↑, MPT↑, ROS↑, eff↓, OCR↓, eff↑,
6558- BSB,    Involvement of mitochondrial permeability transition pore opening in α-bisabolol induced apoptosis
OCR↓, MPT↑, selectivity↑, ROS↑, eff↓, *ROS∅, cl‑PARP↑, MMP↓, eff↑,
2347- CAP,    Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
- in-vivo, Nor, NA - in-vitro, Nor, RAW264.7
*PKM2↓, *LDHA↓, *Warburg↓, *COX2↓, *Sepsis↓, *Inflam↓, *ECAR↓, *OCR↑,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
1577- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet
- in-vivo, PC, NA - in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988 - in-vitro, PC, MIA PaCa-2
Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,
6146- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high‐fat diet
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCG↓, SPARC↑, Glycolysis↓, OCR↓, ATP↓, NF-kB↓, Ca+2↑,
4761- CoQ10,    Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
*ETC↝, ROS↑, *antiOx↑, ROS↑, OCR↓, MMP↓, TumCD↑, TumCG↓, other↝,
6313- Cro,    Crocetin and related oxygen diffusion‐enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications
- Review, Covid, NA - Review, Var, NA - Review, Stroke, NA
RadioS↑, *other↑, *other↑, *OCR↑, *neuroP↑, ChemoSen↑, ROS↑,
6236- CUSP9,  EP,    Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro
- in-vitro, GBM, U251
Apoptosis↑, MOMP↓, Casp2↑, Bcl-2↓, Mcl-1↓, eff↑, OCR↓, OXPHOS↓, TumCMig↓,
6249- Cyc,    Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
HH↓, OCR↓, TumCP↓, Apoptosis↑, ROS↑, MMP↑, mtDam↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6680- DCA,    The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation
- NA, Laryn, FaDu
PDH↓, PDKs↓, OCR↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1872- DCA,    Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment
- in-vitro, Oral, HSC2 - in-vitro, Oral, HSC3
PDKs↓, ROS↑, OCR↑, other↑,
6669- Deg,    Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
- vitro+vivo, Pca, NA
other↝, ETC↓, TumCG↓, OCR↓, GlucoseCon↑, MMP↓, other↝,
6696- DFC,  MET,    Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma
- in-vitro, GBM, GBM
compI↓, Glycolysis↓, OCR↓, Glycolysis↑, lactateProd↓, eff↑, TumCP↓, TumCMig↓, TumCD∅,
951- DHA,    Docosahexaenoic Acid Attenuates Breast Cancer Cell Metabolism and the Warburg Phenotype by Targeting Bioenergetic Function
- in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Hif1a↓, GLUT1↓, LDH↓, GlucoseCon↓, lactateProd↓, ATP↓, p‑AMPK↑, ECAR↓, OCR↓, *toxicity↓,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
694- EGCG,    Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways
- in-vitro, BC, MCF7
Glycolysis↓, GAPDH↓, ROS↑, OCR↓, ECAR↓, mTOR↓, OXPHOS↓,
5526- EP,    Nanosecond Pulsed Electric Field Modulates Electron Transport and Mitochondrial Structure and Function
- Review, Var, NA
CellMemb↑, ROS↑, ETC↝, OCR↓, MMP↓,
5529- EP,    Effects of nsPEFs on Electron Transport and Mitochondrial Structures and Functions
- Review, Var, NA
ETC↓, OCR↓, CellMemb↑, mt-ROS↑, MMP↓,
6971- Form,    In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa
- vitro+vivo, Cerv, HeLa
p‑Akt↓, Apoptosis↑, TumCG↓, Dose↝, PI3K↓, eff↑, ATP↓, OCR↓, TumCCA↑, IGF-1↓, angioG↓, TumCI↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
7234- GBE,    Ginkgo Biloba Extract Ameliorates Oxidative Phosphorylation Performance and Rescues Aβ-Induced Failure
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *OXPHOS↑, *OCR↑, *compI↓,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
960- HNK,    Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
OCR↑, ECAR↓, GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PDK1↓, Apoptosis↑, LDHA↓,
2178- itraC,    Itraconazole inhibits tumor growth via CEBPB-mediated glycolysis in colorectal cancer
- in-vivo, CRC, HCT116
TumCG↓, Glycolysis↓, CEBPB?, ENO1↓, LDHA↓, PKM2↓, GAPDH↓, ECAR↓, OCR↓,
4779- Lyco,    Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, PANC1
ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4789- Lyco,    Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells
- in-vitro, AD, SH-SY5Y
*antiOx↑, *ROS↓, *NF-kB↓, *neuroP↑, *MMP↓, *mtDam↓, *OCR↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
2543- M-Blu,    The use of methylene blue to control the tumor oxygenation level
- in-vivo, Lung, NA
OCR↑, OXPHOS↑, Half-Life↝, AntiTum↑,
2542- M-Blu,    In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death
- in-vitro, Ovarian, OV1369 - in-vitro, Ovarian, OV1946 - in-vitro, Nor, ARPE-19
BioAv↝, TumCP↓, GlutaM↓, Warburg↓, OCR↑, Glycolysis↓, ATP↓, BioAv↝, ROS↑,
2541- M-Blu,    Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism
- in-vivo, Var, NA
TumCG↓, Glycolysis↓, OXPHOS↑, ROS↑, OCR↑, GlucoseCon↑, lactateProd↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
2260- MF,    Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229 - in-vivo, NA, NA
TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,

Showing Research Papers: 1 to 50 of 61
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 61

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-375↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   compI↓, 1,   GSTs↑, 1,   GSTZ1↓, 1,   HO-1↓, 2,   HO-1↑, 1,   MAD↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 6,   mt-OXPHOS↑, 1,   ROS↓, 2,   ROS↑, 21,   ROS⇅, 1,   mt-ROS↑, 3,   SOD2↑, 2,   TrxR↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 11,   i-ATP↑, 1,   ETC↓, 2,   ETC↝, 1,   mitResp↓, 5,   MMP↓, 10,   MMP↑, 1,   MPT↑, 2,   mtDam↑, 1,   OCR↓, 27,   OCR↑, 13,   mt-OCR↓, 1,   PGC-1α↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACLY↓, 1,   AminoA↓, 1,   AMP↑, 1,   AMPK↑, 4,   p‑AMPK↑, 2,   ATP:AMP↓, 1,   Cav1↑, 1,   cMyc↓, 2,   CRM↑, 1,   ECAR↓, 11,   ECAR↑, 1,   ECAR∅, 1,   ENO1↓, 1,   GAPDH↓, 2,   GlucoseCon↓, 5,   GlucoseCon↑, 2,   GLUT2↓, 1,   GlutaM↓, 1,   Glycolysis↓, 17,   Glycolysis↑, 1,   HK2↓, 4,   HMG-CoA↓, 1,   lactateProd↓, 13,   LDH↓, 2,   LDHA↓, 5,   lipoGen↓, 2,   NAD↓, 1,   NADPH↓, 1,   PDH↓, 1,   PDH↝, 1,   p‑PDH↑, 1,   PDK1↓, 5,   p‑PDK1↓, 2,   PDKs↓, 3,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   p‑Akt↓, 2,   Apoptosis↑, 15,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-2↑, 1,   BID↓, 1,   Casp↑, 1,   Casp2↑, 1,   Casp3↑, 9,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 2,   cFLIP↓, 2,   Cyt‑c↑, 4,   Cyt‑c↝, 1,   DR4↑, 1,   DR5↑, 1,   hTERT/TERT↓, 1,   MAPK↓, 1,   Mcl-1↓, 1,   MOMP↓, 1,   Myc↓, 1,   p27↑, 1,   survivin↓, 4,   Telomerase↓, 1,   TumCD↑, 1,   TumCD∅, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

FOXD3↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 5,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B-II↑, 1,   LC3II↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNA-PK↑, 1,   DNAdam↑, 2,   P53↑, 2,   cl‑PARP↑, 4,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 1,   Cyc↓, 1,   cycD1/CCND1↓, 2,   cycD1/CCND1↑, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 1,   CEBPB?, 1,   CIP2A↓, 2,   CSCs↓, 2,   EMT↓, 3,   ERK↓, 1,   FOXM1↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   mTOR↓, 5,   NOTCH↓, 2,   PI3K↓, 6,   PTEN↑, 3,   RAS↓, 2,   STAT3↓, 3,   p‑STAT3↓, 1,   TOP1↓, 1,   TumCG↓, 11,   TumCG↑, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   i-Ca+2↑, 1,   E-cadherin↑, 3,   Ki-67↓, 1,   MMP2↓, 4,   MMP9↓, 3,   N-cadherin↓, 2,   PKA↓, 1,   PKCδ↓, 1,   Rho↑, 1,   ROCK1↑, 1,   Snail↓, 2,   SPARC↑, 2,   TGF-β↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 13,   TumMeta↓, 3,   Twist↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   EGFR↓, 1,   Hif1a↓, 7,   NO↝, 1,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   CellMemb↑, 2,   GLUT1↓, 4,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   COX2↑, 1,   IL1↑, 1,   IL10↑, 1,   Inflam↓, 1,   pol-M1↑, 1,   pol-M2 MC↓, 1,   NF-kB↓, 6,   p65↓, 1,   PD-1↓, 1,   PGE2↓, 1,   T-Cell↑, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   ChemoSen↑, 5,   Dose↝, 3,   Dose∅, 2,   eff↓, 10,   eff↑, 15,   Half-Life↓, 1,   Half-Life↝, 1,   RadioS↑, 5,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   BMPs↑, 1,   EGFR↓, 1,   FOXM1↓, 1,   hTERT/TERT↓, 1,   Ki-67↓, 1,   LDH↓, 2,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   fatigue↓, 1,   neuroP↑, 2,   OS↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 240

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   mt-antiOx↑, 1,   Catalase↑, 1,   compI↓, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   Keap1↑, 1,   lipidDe↓, 1,   MDA↓, 2,   NQO1↑, 1,   NRF2↑, 2,   OXPHOS↑, 1,   ROS↓, 7,   ROS∅, 1,   SIRT3↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   ETC↝, 1,   MMP↓, 1,   mtDam↓, 1,   OCR↓, 4,   OCR↑, 5,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   p‑ACC↑, 1,   ALAT↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   ECAR↓, 2,   ECAR↑, 1,   FAO↑, 1,   glucose↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   HK2↑, 1,   LDHA↓, 1,   LDHA↑, 1,   PDKs↓, 1,   PFK↓, 1,   PKM2↓, 1,   PKM2↑, 1,   PPARγ↑, 1,   SREBP1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↑, 1,   Casp3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   GSK‐3β↓, 1,   mTOR↓, 1,   Nestin↑, 1,   NOTCH1↑, 1,   PI3K↑, 1,   SOX2↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ki-67↑, 1,   Rho↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 3,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   MAOB↓, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 2,   eff↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   GutMicro↑, 1,   Ki-67↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 2,   memory↑, 3,   neuroP↑, 4,   Obesity↓, 1,   toxicity↓, 1,   toxicity∅, 3,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 2,  
Total Targets: 93

Scientific Paper Hit Count for: OCR, Oxygen consumption rate
5 Methylene blue
4 Dichloroacetate
4 Honokiol
4 Magnetic Fields
3 Betulinic acid
3 Citric Acid
3 Electrical Pulses
2 α-Bisabolol / Chamomile oil
2 Metformin
2 Lycopene
1 3-bromopyruvate
1 5-Aminolevulinic acid
1 Auranofin
1 Alpha-Lipoic-Acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Baicalin
1 Berberine
1 Capsaicin
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 CUSP9
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Formononetin
1 Gambogic Acid
1 Ginkgo biloba
1 HydroxyCitric Acid
1 itraconazole
1 Magnetic Field Rotating
1 Phenylbutyrate
1 Propolis -bee glue
1 Phenethyl isothiocyanate
1 Quercetin
1 Resveratrol
1 Shikonin
1 Vitamin B5,Pantothenic Acid
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:846  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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