TBARS Cancer Research Results

TBARS, Thiobarbituric Acid Reactive Substances: Click to Expand ⟱
Source:
Type: measure
TBARS (Thiobarbituric Acid Reactive Substances) is a measure of lipid peroxidation, which is the oxidative degradation of lipids. Lipid peroxidation is a process in which free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs), leading to cell damage.

Research has shown that TBARS levels are often elevated in cancer patients. This is because cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, which can lead to increased lipid peroxidation.
Scientific Papers found: Click to Expand⟱
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
727- Bor,  RSL3,  erastin,    Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy
- in-vitro, Liver, HepG2
ROS↑, GSH↓, TBARS↑, Ferroptosis↑, ChemoSen↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL6↑, *MMP13↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
6308- Cro,    Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
- vitro+vivo, PC, Bxpc-3
Bcl-2↓, Apoptosis↑, Cyt‑c↑, TumCG↓, radioP↑, TumCCA↑, TumCP↓, DNAdam↑, TBARS↓, P53↑, p38↑, CDK2↓, cMyc↓, *MDA↓, GSH↑,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, MMP↓, Apoptosis↑, TBARS↑, GSH↓, SOD↓, BAX↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, mTOR↓, DNAdam↑, ROS↑,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1↓,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GSH↓, 5,   GSH↑, 1,   ROS↓, 1,   ROS↑, 5,   SOD↓, 2,   TBARS↓, 1,   TBARS↑, 4,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 6,   Bak↓, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   BID↑, 1,   Casp↝, 1,   Casp12↑, 1,   Casp3↑, 5,   Casp8↑, 3,   Casp9↑, 4,   Cyt‑c↑, 3,   Fas↑, 2,   Ferroptosis↑, 1,   p38↑, 2,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↑, 2,   P53↑, 4,   P53↝, 1,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

FGF↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG↓, 1,   TumCG↑, 1,  

Migration ⓘ

CEA↓, 1,   p‑FAK↓, 1,   MMP9↓, 1,   TIMP2↑, 1,   TumCMig↓, 2,   TumCP↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↑, 1,   Hif1a↓, 2,   VEGF↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL6↓, 1,   IL8↓, 1,   NF-kB↑, 1,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

CEA↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   chemoP↑, 1,   radioP↑, 1,  
Total Targets: 76

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiArt↑, 1,   AntiBio↑, 3,  

Redox & Oxidative Stress ⓘ

antiOx↑, 5,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 7,   GSTs↑, 3,   HO-1↑, 3,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 3,   MDA↓, 4,   MPO↓, 2,   NRF2↑, 5,   ROS↓, 7,   SOD↑, 8,   TBARS↓, 5,   TBARS↑, 1,   uricA↓, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   H2S↑, 1,   LDH↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Cyt‑c↓, 1,   iNOS↓, 6,   JNK↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   HDAC↓, 1,   PI3K↓, 1,  

Migration ⓘ

MMP13↓, 1,  

Angiogenesis & Vasculature ⓘ

p‑eNOS↑, 1,   NO↓, 3,  

Barriers & Transport ⓘ

BBB↑, 2,   GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 5,   IFN-γ↓, 1,   IL17↓, 1,   IL1β↓, 3,   IL6↓, 2,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 5,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   BChE↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   BACE↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   creat↓, 2,   GutMicro↑, 1,   IL6↓, 2,   IL6↑, 1,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 4,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 4,   motorD↑, 1,   neuroP↑, 8,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   CD8+↑, 1,  
Total Targets: 89

Scientific Paper Hit Count for: TBARS, Thiobarbituric Acid Reactive Substances
2 Allicin (mainly Garlic)
2 Geraniol
1 Boron
1 Ras-selective lethal 3
1 erastin
1 α-Bisabolol / Chamomile oil
1 Chrysin
1 Crocetin
1 Carvone
1 Ellagic acid
1 Radiotherapy/Radiation
1 Piperine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:862  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page