AntiTum Cancer Research Results

AntiTum, AntiTumor: Click to Expand ⟱

Source:

Type:

AntiTumor

Scientific Papers found: Click to Expand⟱

6475-

1,8-Cin,

1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expression

-

in-vitro,

HNSCC,

NA

*P-sel↓, Inflam↓, AntiTum↑, AntiAg↑,

6466-

1,8-Cin,

Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y

-

in-vitro,

neuroblastoma,

SH-SY5Y

AntiTum↑, TumCCA↑, PDGFRB↓, Myc↓, LEF1↓, BAD↑, APC↑, TBX3↑,

5269-

3BP,

The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.

-

in-vitro,

HCC,

NA

toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,

5314-

acetaz,

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

-

Review,

Var,

NA

AntiTum↑, CA↓,

5471-

AF,

Anti-Tumoral Treatment with Thioredoxin Reductase 1 Inhibitor Auranofin Fosters Regulatory T Cell and B16F10 Expansion in Mice

-

vitro+vivo,

Melanoma,

B16-F10

TrxR1↓, AntiTum↑, ROS↑, NRF2↑, TumCD↑,

5462-

AF,

Repurposing Auranofin for Oncology and Beyond: A Brief Overview of Clinical Trials as Mono- and Combination Therapy

-

Review,

Var,

NA

AntiTum↑, Bacteria↓, TrxR↓, ChemoSen↑, Dose↝, ROS↑, Apoptosis↑, mTOR↓,

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

5444-

AG,

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

-

Review,

Var,

NA

*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

4546-

AgNPs,

Chapter 2 - Silver nanoparticles in cancer therapy

-

Study,

Var,

NA

AntiTum↑, Apoptosis↑,

4394-

AgNPs,

Silver nanoparticles provoke apoptosis of Dalton's ascites lymphoma in vivo by mitochondria dependent and independent pathways

-

in-vivo,

lymphoma,

NA

OS↑, TumVol↓, Weight↑, AntiTum↑, Apoptosis↑, mtDam↑,

4383-

AgNPs,

Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies

-

in-vitro,

Lung,

A549

AgNPs was 23.45 nm, with zeta potentials lying on −20.33 mV.

-

in-vivo,

Lung,

A549

A549 and A549/DDP-bearing mice

Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, ChemoSen↑, CTR1↑,

4378-

AgNPs,

Exploring silver nanoparticles for cancer therapy and diagnosis

-

Review,

Var,

NA

AntiTum↑, ROS↑, ChemoSen↑, RadioS↑,

4364-

AgNPs,

Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties

-

in-vitro,

BC,

MCF7

31.4 nm with a Zeta potential of −33.8 mV,

TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,

5352-

AL,

Anticancer potential of allicin: A review

-

Review,

Var,

NA

*cardioP↑, *Bacteria↓, *Inflam↓, AntiTum↑, *DNAdam↓, TumCP↓, angioG↓, TumMeta↓,

2657-

AL,

Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases

-

Review,

CardioV,

NA

-

Review,

AD,

NA

*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,

6601-

Anamu,

Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model

-

in-vitro,

AML,

NA

AntiTum↑, GlucoseCon↓, ROS↑, TumCP↓, eff↓, Glycolysis↓,

6398-

ANE,

trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells

-

in-vitro,

OS,

MG63

*Inflam↓, *AntiTum↑, TumCCA↓, ROS↑, MMP↓, Casp3↑, Casp9↑, P53↑, Bcl-xL↓, MPT↑,

2593-

Api,

Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo

-

in-vivo,

BC,

4T1

4T1 xenograft tumor mouse model

TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↑, ROS↑, p‑PI3K↓, PI3K↓, Akt↓, NRF2↓, AntiTum↑, OS↑,

2571-

ART/DHA,

Cancer combination therapies with artemisinin-type drugs

-

Review,

Var,

NA

AntiTum↑, ChemoSen↑, hepatoP↝,

5133-

ART/DHA,

Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

U251

AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP/DDIT3↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,

4678-

Ash,

Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer

-

vitro+vivo,

NSCLC,

H1975

ROS↑, AntiTum↑, CSCs↓, mTOR↓, STAT3↓, ChemoSen↑, Keap1↑, NRF2↓,

5169-

Ash,

The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin

-

in-vitro,

BC,

MCF7

AntiTum↑, angioG↓, Vim↓,

5175-

Ash,

Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

-

in-vitro,

Cerv,

CCL-102

Inflam↓, AntiTum↑, Proteasome↓, ER Stress↑, HSPs↑, GRP94↑, Akt↑, Synergy↑, HSP70/HSPA5↑,

5424-

ASTX,

Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity

-

in-vivo,

Nor,

NA

mice

*GutMicro↑, AntiCan↑, Synergy↑, AntiTum↑, ChemoSen↑,

4819-

ASTX,

Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway

-

in-vitro,

BC,

MCF7

5, 10, 25, 50, 75, 100, 125, and 150 μg/mL)

IC50 = 89.742 μg/mL

antiOx↑, AntiTum↑, TumCD↑, P53↑, P21↑, Apoptosis↑, Dose↝, Casp3↑,

4818-

ASTX,

MLT,

Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

T47D

-

in-vitro,

Nor,

MCF10

TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, Synergy↑, Dose↓,

4804-

ASTX,

Astaxanthin in cancer therapy and prevention (Review)

-

Review,

Var,

NA

-

Review,

AD,

NA

*antiOx↑, *Inflam↓, ChemoSen⇅, chemoP↑, BioAv↑, TumCP↑, ROS⇅, Apoptosis↑, PI3K↑, Akt↑, GSK‐3β↑, NRF2↑, AntiCan↑, *neuroP↑, Synergy↑, AntiTum↑,

4813-

ASTX,

Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function

-

in-vitro,

AD,

NA

*antiOx↑, *Apoptosis↓, *AntiTum↑, *ROS↓, *MMP↑, *neuroP↑,

5448-

ATV,

Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology

-

Review,

Var,

NA

Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,

5364-

AV,

A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application

-

Review,

Var,

NA

BioAv↑, AntiTum↑, cardioP↑,

5365-

AV,

Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications

-

Review,

Nor,

NA

-

Review,

IBD,

NA

-

Review,

Diabetic,

NA

*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,

5577-

B-Gluc,

Lentinan progress in inflammatory diseases and tumor diseases

-

Review,

Var,

NA

-

Review,

IBD,

NA

AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,

5580-

B-Gluc,

Lentinan, a Shiitake Mushroom β-Glucan, Downregulates the Enhanced PD-L1 Expression Induced by Platinum Compounds in Gastric Cancer Cells

-

in-vitro,

GC,

MKN45

PD-L1↓, MAPK↓, OS↑, AntiTum↑, Imm↑,

876-

B-Gluc,

Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future

-

Review,

Var,

NA

AntiTum↑,

5501-

Ba,

Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review

-

Review,

GC,

NA

AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,

5251-

Ba,

The Fascinating Effects of Baicalein on Cancer: A Review

-

Review,

Var,

NA

AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,

2022-

BBR,

GoldNP,

Rad,

Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

-

in-vitro,

Liver,

SMMC-7721 cell

-

in-vitro,

Nor,

HL7702

*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,

2674-

BBR,

Berberine: A novel therapeutic strategy for cancer

-

Review,

Var,

NA

-

Review,

IBD,

NA

Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,

6503-

BCP,

The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer

-

Review,

Var,

NA

ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,

5584-

BetA,

Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors

-

in-vitro,

GBM,

A172

-

in-vitro,

GBM,

U118MG

-

in-vitro,

GBM,

U251

Apoptosis↑, P53↑, Cyt‑c↑, AIF↑, Casp↑, AntiTum↑, MMP↓,

2724-

BetA,

Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice

-

in-vivo,

Nor,

NA

mice

-

in-vivo,

Stroke,

NA

AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,

2760-

BetA,

A Review on Preparation of Betulinic Acid and Its Biological Activities

-

Review,

Var,

NA

-

Review,

Stroke,

NA

AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,

5718-

BF,

Bufalin inhibits CYP3A4 activity in vitro and in vivo

-

in-vivo,

Nor,

NA

Wistar rats

CYP3A4↓, Apoptosis↑, AntiTum↑,

5628-

Bif,

immuno,

Bifidobacterium modulation of tumor immunotherapy and its mechanism

-

Review,

Var,

NA

Imm↑, Risk↓, GutMicro↑, AntiTum↑, OS↑, selectivity↑, Synergy↑,

5629-

Bif,

ProBio,

Gut microbiota shapes cancer immunotherapy responses

-

Review,

Var,

NA

eff↑, DCells↑, CD8+↑, eff↑, AntiTum↑, other↑, selectivity↑, GutMicro↑,

9203-

BITC,

Benzyl isothiocyanate inhibits tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in a BALB/c mouse xenograft model

-

vitro+vivo,

BC,

4T1

BALB/c mouse xenograft model

AntiTum↑, Dose↝, TumVol↓, TumW↓, PCNA↓, Bcl-2↓, CD31/PECAM-1↓, VEGF↓, BAX↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp9↑, cl‑PARP↑, TumNum↓, TumMeta↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓, TIMP2↑, PAI-1/SERPINE1↑,

9211-

BITC,

Apoptosis induced by benzyl isothiocyanate in gefitinib-resistant lung cancer cells is associated with Akt/MAPK pathways and generation of reactive oxygen species

-

in-vitro,

NSCLC,

NA

AntiTum↑, TumCG↓, Apoptosis↑, Casp3↑, TumCCA↑, ROS↑, GSH↓, eff↑,

9167-

BITC,

Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice

-

vitro+vivo,

BC,

4T1

AntiTum↑, Dose↝, CD31/PECAM-1↓, VEGF↓, PCNA↓, CDK4↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓,

5686-

BJ,

BRU,

A review of Brucea javanica: metabolites, pharmacology and clinical application

-

Review,

Var,

NA

AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2/PTGS2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,

Showing Research Papers: 1 to 50 of 252
Page 1 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 252

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5, Copper↓, 1, GPx4↓, 4, GSH↓, 5, GSH↑, 1, GSH/GSSG↓, 2, GSR↑, 1, GSTs↑, 1, H2O2↑, 2, HO-1↓, 2, HO-1↑, 2, Iron↑, 3, Iron↝, 1, Keap1↑, 1, lipid-P↓, 1, lipid-P↑, 5, MDA↑, 1, NQO1↓, 1, NQO1↑, 2, NRF2↓, 7, NRF2↑, 6, NRF2↝, 1, ROS?, 2, ROS↓, 6, ROS↑, 79, ROS⇅, 1, i-ROS↑, 1, mt-ROS↑, 2, SOD↓, 2, SOD↑, 2, SOD1↓, 1, Thiols↓, 1, TKT↓, 1, Trx↓, 2, TrxR↓, 2, TrxR1↓, 2, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1, IronCh↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 3, EGF↓, 1, HSP60/HSPD1↓, 1, mtDam?, 1, mtDam↑, 9, OCR↓, 1, OCR↑, 1, OXPHOS↑, 2, OXPHOS↝, 1, PGC-1α↑, 1, PINK1↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 1, ACADS/SCAD↓, 1, p‑ACLY↓, 1, ACSL4↑, 1, ALAT↓, 1, ALDOA↓, 1, AMPK↑, 6, p‑AMPK↑, 1, ATP↓, 6, CAIX/CA9↓, 1, FASN↓, 1, GLO-I↓, 1, glucose↓, 1, GlucoseCon↓, 3, Glycolysis↓, 10, GSK‐3β↓, 2, GSK‐3β↑, 1, HK2↓, 3, HMG-CoA↓, 2, lactateProd↓, 2, LDHA↓, 1, LDL↓, 1, lipidLev↓, 1, lipoGen↓, 1, NADPH↓, 1, PDK3↓, 1, PFKP?, 1, PKM2↓, 2, PPP↓, 2, SCFAs↑, 1, SIRT1↓, 1, SREBP1/SREBF1↓, 2, TCA↓, 2, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

AIF↑, 5, APAF1↑, 1, Apoptosis↓, 3, Apoptosis↑, 83, BAD↓, 2, BAD↑, 1, Bak↓, 1, BAX↑, 34, Bax:Bcl2↑, 4, Bcl-2↓, 44, Bcl-xL↓, 7, BIM↑, 1, Casp↑, 11, Casp12↑, 1, cl‑Casp12↑, 1, Casp3?, 1, Casp3↓, 3, Casp3↑, 31, cl‑Casp3↑, 10, proCasp3↑, 1, Casp6↓, 1, Casp7↑, 5, cl‑Casp7↑, 2, Casp8↓, 1, Casp8↑, 5, proCasp8↑, 1, Casp9↓, 2, Casp9↑, 24, cl‑Casp9↑, 4, proCasp9↑, 1, cFLIP↓, 1, Cyt‑c↓, 1, Cyt‑c↑, 22, DR5↑, 2, DR5↝, 1, FADD↑, 1, Fas↓, 1, Fas↑, 3, FasL↓, 1, FasL↑, 2, Ferroptosis↓, 1, Ferroptosis↑, 5, GSDME↑, 1, IAP1↓, 1, iNOS↓, 4, Mcl-1↓, 4, MDM2↓, 2, MOMP↑, 1, p38↓, 1, p38↑, 2, p‑p38↓, 1, p‑p38↑, 2, pS2/TFF1↓, 1, PUMA↓, 1, Pyro↑, 1, survivin↓, 6, TRAIL⇅, 1, TRAILR↑, 1, TumCD↓, 1, TumCD↑, 10, XIAP↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 31, Akt↑, 4, p‑Akt↓, 9, CaMKII ↑, 1, CREB↑, 1, EGFR↓, 8, ERK↓, 9, ERK↑, 1, p‑ERK↓, 5, HGF/c-Met↓, 1, IGF-1R↓, 1, p‑IKKα↓, 1, JAK↓, 1, JAK1↑, 1, JAK2↓, 1, JNK↓, 2, JNK↑, 4, p‑JNK↑, 2, LIMK1↓, 1, MAPK↓, 11, MAPK↑, 5, p‑MAPK↓, 1, mTOR↓, 18, mTOR↑, 3, p‑mTOR↓, 2, PDGFRB↓, 1, PI3K↓, 23, PI3K↑, 1, p‑PI3K↓, 2, PKCδ↓, 1, PTEN↓, 1, PTEN↑, 7, e-Raf↓, 1, RAS↓, 4, Sp1/3/4↓, 2, STAT3↓, 8, STAT3↑, 1, p‑STAT3↓, 1, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3, cJun↑, 2, EZH2↓, 1, FOXM1↓, 1, FOXO1↑, 1, FOXO3↑, 1, FOXO4↑, 1, HDAC↓, 4, HDAC1↓, 1, HES1↓, 1, HOXB-AS1↓, 1, JPT1/HN1↓, 1, LINC01116↓, 1, miR-10b-5p↓, 1, miR-133a-3p↑, 1, miR-139-5p↑, 1, miR-182-5p↓, 1, miR-19b↓, 1, miR-21↓, 3, miR-34a↑, 1, miR-592↑, 1, MTA2↓, 1, Myc↓, 1, OCT4↓, 2, other↓, 2, other↑, 2, other↝, 8, PhotoS↑, 3, sonoS↑, 1, SOX2↓, 1, SOX4↓, 1, SUMO↓, 1, TBX3↑, 1, tumCV↓, 18,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 2, CHOP/DDIT3↝, 1, eIF2α↑, 2, p‑eIF2α↓, 1, ER Stress↑, 11, Erlin1↑, 1, GRP78/BiP↓, 1, GRP78/BiP↑, 1, GRP94↑, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 2, HSP90↓, 2, HSPs↑, 1, IRE1↑, 1, NQO2↑, 1, PERK↑, 3, Proteasome↓, 1, UPR↑, 1, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2, LC3B-II↑, 1, LC3II↓, 1, LC3II↑, 2, MitoP↓, 1, p62↓, 2, PARK2↑, 1, TumAuto↓, 1, TumAuto↑, 17,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, DNAdam↓, 1, DNAdam↑, 11, DNArepair↓, 2, hTERT/TERT↓, 1, P53↓, 4, P53↑, 16, p‑P53↑, 1, p53 Wildtype↓, 1, PARP↑, 5, cl‑PARP↑, 16, PCNA↓, 3, PCNA↑, 1, TOP1↓, 1, γH2AX↑, 2, γH2AX↝, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1, CDK2↓, 4, CDK2↑, 1, CDK4↓, 5, CDK6↓, 1, CDKN1C/p57↓, 1, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 5, CycB/CCNB1↑, 1, cycD1/CCND1↓, 15, cycE/CCNE↓, 3, Ki-67↓, 10, mitA↑, 1, P21↑, 11, p27/CDKN1B↓, 2, p27/CDKN1B↑, 4, pRB↓, 1, RB1↑, 1, Securin↓, 1, TumCCA?, 1, TumCCA↓, 2, TumCCA↑, 48,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2, BMI1↓, 1, BMPs↑, 1, CD133↓, 1, CSCs↓, 8, CSCs↑, 1, Diff↑, 3, FGF↓, 1, GTPBP4↓, 1, HH↓, 1, HMGCR↓, 1, IGF-1↓, 1, JAG1↓, 1, Ki-67↓, 10, Let-7↑, 1, mTORC1↓, 1, Nanog↓, 1, NOTCH↓, 2, NOTCH1↓, 4, NOTCH3↓, 1, Piezo1↑, 1, Shh↓, 1, Smo↓, 1, TumCG↓, 43, TumCG↑, 1, TumCP↓, 45, TumCP↑, 2, TumCP⇅, 1, Wnt↓, 5,

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 1, APC↑, 1, ATPase↓, 1, CA↓, 1, Ca+2↑, 8, Ca+2↝, 2, i-Ca+2↑, 1, cal2↑, 1, CCN2/CTGF↓, 1, Cofilin↓, 1, E-cadherin↓, 1, E-cadherin↑, 16, EMT↓, 20, EMT↑, 1, FAK↓, 3, p‑FAK↓, 1, LEF1↓, 1, MMP1↓, 1, MMP13↓, 2, MMP2↓, 24, MMP3↓, 3, MMP7↓, 1, MMP9↓, 26, MMP9↑, 1, MMPs↓, 5, MUC1↑, 1, N-cadherin↓, 10, PAI-1/SERPINE1↑, 1, PAK1↓, 1, Rho↓, 1, ROCK1↓, 2, Sharpin↓, 1, Slug↓, 1, Smad1↑, 1, SMAD4↓, 1, Snail↓, 5, TGF-β↓, 2, TGF-β↑, 1, TGF-β1↓, 1, TIMP1↓, 2, TIMP1↑, 3, TIMP2↑, 3, TumCI?, 1, TumCI↓, 30, TumCMig↓, 29, TumMeta↓, 29, TumMeta↑, 2, Twist↓, 1, uPA↓, 5, uPAR↓, 1, Vim↓, 11, Zeb1↓, 2, ZEB2↓, 1, β-catenin/ZEB1↓, 7, β-catenin/ZEB1↑, 1, cl‑β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 24, CD31/PECAM-1↓, 4, HIF-1↓, 2, Hif1a↓, 7, HIF2a↓, 1, VCAM-1↓, 1, VEGF↓, 17, VEGFR2/KDR/Flk1↓, 4,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, CTR1↑, 1, EPR↑, 4, GLUT1↓, 1, IBI↑, 1, MMP↓, 30, MMP↑, 1, MPT↑, 1, TJ↑, 1, TRPV1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CD4+↓, 1, CD4+↑, 3, CD44↓, 3, CD8+↑, 5, COX2/PTGS2↓, 12, COX2/PTGS2↑, 1, DCells↑, 1, HMGB1↓, 2, ICAM-1↓, 1, IFN-γ↑, 2, IL1↓, 1, IL10↑, 1, IL12↑, 1, IL1β↓, 1, IL1β↑, 2, IL2↓, 1, IL6↓, 7, IL8↓, 3, IL8↑, 1, Imm↑, 13, Imm↝, 1, Inflam↓, 16, IRAK1↓, 1, Macrophages↓, 1, MCP1/CCL2↓, 3, MCT1↓, 1, NAF1↓, 1, Neut↓, 1, NF-kB↓, 29, NK cell↑, 3, NOD1↓, 1, p65↓, 1, PD-1↓, 1, PD-1↝, 1, PD-L1↓, 3, PGE2↓, 3, PSA↓, 1, SOCS-3↓, 1, T-Cell↑, 2, TLR4↓, 2, TNF-α↓, 5, TNF-α↑, 3,

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1, TAMS↑, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1, 4-OHE1↓, 1, AhR↓, 1, AR↝, 1, ER-α36↓, 1, FGF21↓, 1, PPARγ↑, 3, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10, BioAv↑, 13, BioAv↝, 2, chemoR↓, 1, ChemoSen↑, 49, ChemoSen⇅, 1, CYP1A1↑, 1, CYP1B1↓, 1, CYP3A4↓, 1, DDS↑, 1, Dose?, 1, Dose↓, 1, Dose↑, 2, Dose↝, 30, Dose∅, 1, eff↓, 13, eff↑, 38, eff↝, 3, GSTA1↑, 1, GSTM1↑, 1, Half-Life↓, 1, Half-Life↑, 2, Half-Life↝, 3, MDR1↑, 1, MRP1/ABCC1↓, 2, P-gp/ABCB1↓, 7, P450↓, 1, RadioS↑, 14, selectivity↓, 1, selectivity↑, 28, Synergy↑, 30,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AR↝, 1, AST↓, 1, CIT↓, 1, CRP↓, 1, EGFR↓, 8, EZH2↓, 1, Ferritin↑, 1, FOXM1↓, 1, hTERT/TERT↓, 1, IL6↓, 7, LDH↓, 1, LDH↑, 1, e-LDH↑, 1, Myc↓, 1, NLR↓, 1, PD-L1↓, 3, PSA↓, 1, TG/TAG↓, 1, Tumccf↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 17, antiD↑, 1, AntiDiabetic↑, 1, antiNeop↑, 1, AntiTum↓, 8, AntiTum↑, 204, AntiTum⇅, 1, AntiTum↝, 1, AntiTum∅, 1, cachexia↓, 1, cardioP↑, 4, chemoP↑, 14, chemoPv↑, 4, cognitive↑, 1, fatigue↓, 1, hepatoP↑, 3, hepatoP↝, 1, neuroP↑, 3, OS↑, 16, Pain↓, 2, QoL↑, 4, radioP↑, 6, RenoP↑, 3, Risk↓, 8, toxicity↓, 7, toxicity↑, 4, toxicity↝, 8, toxicity∅, 3, TumNum↓, 1, TumVol↓, 8, TumVol↑, 1, TumW↓, 5, Weight↓, 1, Weight↑, 2, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, AntiP↑, 1, AntiViral↑, 1, Bacteria↓, 3, GutMicro↑, 9, Sepsis↓, 3,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,
Total Targets: 537

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4, antiOx↑, 55, Catalase↑, 6, GPx↑, 8, GPx4↑, 1, GSH↑, 6, GSTs↑, 4, H2O2↓, 2, HDL↑, 3, HNE↓, 1, HO-1↓, 1, HO-1↑, 8, hyperG↓, 1, Keap1↓, 1, lipid-P↓, 9, MDA↓, 5, MPO↓, 3, NADH↓, 1, NOX4↓, 2, NQO1↑, 3, NQO1↝, 1, NRF2↑, 17, RNS↓, 1, ROS↓, 32, ROS↑, 1, ROS∅, 2, selenoP↑, 2, SOD↑, 13, SOD1↑, 1, TAC↑, 2, TBARS↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ALAT↓, 2, AMPK↑, 2, ATP↑, 1, FFA/NEFA↓, 1, glucose↓, 4, glucose↝, 1, GSK‐3β↓, 2, p‑GSK‐3β↑, 1, HMG-CoA↓, 1, LDL↓, 4, PLA2↓, 1, SCFAs↑, 1, SIRT1↑, 2,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 5, Casp12↓, 1, Casp3↓, 2, Casp9↓, 1, Fas↓, 1, Ferroptosis↓, 1, iNOS↓, 3,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1, p‑Akt↑, 1, p‑ERK↑, 1, HGF/c-Met↑, 1, JAK↓, 1, MAPK↓, 3, mTOR↓, 1, mTOR↑, 1, PI3K↓, 1, PI3K↑, 1, PROKR1↑, 1, PROKR2↑, 1, STAT3↓, 1, STAT3↑, 1, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3, HOTAIR↑, 1, miR-34a↓, 1, other?, 1, other↓, 3, other↑, 2, other↝, 2,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1, CHOP/DDIT3↓, 2, CHOP/DDIT3↑, 1, ER Stress↓, 3, GRP78/BiP↓, 2, GRP78/BiP↑, 1, GRP94↑, 1, HSP70/HSPA5↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1, p62↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

AntiAg↑, 5, PROK2↑, 1, TIMP1↓, 1, TumMeta↓, 1, α-SMA↓, 1, α-tubulin↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2, p‑eNOS↑, 1, Hif1a↓, 1, Hif1a↑, 1, NO?, 1, NO↓, 4, P-sel↓, 1, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2, GastroP↑, 3, GLUT2↑, 1, IBI↑, 2, MMP↑, 2, OCLN↑, 1, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1, CD8+↑, 1, COX1↓, 1, COX1↑, 1, COX2/PTGS2↓, 4, ICAM-1↓, 1, IFN-γ↑, 1, IL10↓, 1, IL10↑, 1, IL1β↓, 6, IL6↓, 5, Imm↑, 13, Inflam↓, 66, Inflam↑, 1, MCP1/CCL2↓, 1, MyD88↓, 1, NF-kB↓, 13, NK cell↑, 2, NLRP3↓, 2, PGE2↓, 2, TLR2↓, 1, TLR4↓, 5, TNF-α↓, 8, TNF-α↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 5, BChE↓, 1, BDNF↑, 1, proBDNF↑, 1, GABA↑, 1, GABA↝, 1, NGF↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, Aβ↓, 4,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 2, PPARγ↑, 1, RAAS↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9, BioAv↑, 12, BioAv↝, 12, BioEnh↑, 1, CYP1A1↑, 1, CYP1A2↑, 1, Dose↝, 4, eff↑, 4, eff↝, 2, Half-Life↓, 4, Half-Life↝, 3, Synergy↑, 3,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, AST↓, 2, BP↓, 2, BP↝, 1, CRP↓, 1, IL6↓, 5, LDH↓, 2, NOS2↓, 1, TC↓, 1, TG/TAG↓, 2,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2, AntiAge↑, 3, antiAll↑, 2, AntiArt↑, 2, AntiCan↑, 3, antiD↑, 1, AntiDiabetic↑, 16, AntiTum↓, 2, AntiTum↑, 36, ANXi↓, 1, cardioP↑, 19, chemoP↑, 2, chemoPv↑, 1, cognitive↑, 4, diuretic↑, 2, hepatoP↑, 17, Learn↑, 1, memory↑, 3, Mood↑, 1, neuroP↑, 23, Obesity↓, 5, QoL↓, 1, radioP↑, 3, RenoP↑, 5, Risk↓, 1, Sleep↑, 1, Stroke↓, 5, toxicity↓, 23, toxicity↑, 4, toxicity↝, 5, toxicity∅, 1, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6, AntiFungal↑, 3, AntiP↓, 1, AntiP↑, 4, AntiViral↑, 8, Bacteria↓, 20, GutMicro↑, 9, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2, Ingr↝, 7,
Total Targets: 210

Scientific Paper Hit Count for: AntiTum, AntiTumor

7 Licochalcone A
6 chitosan
6 Selenite (Sodium)
5 Silver-NanoParticles
5 Astaxanthin
5 immunotherapy
5 Isoliquiritigenin
5 Hydrogen Gas
5 Kaempferol
4 Radiotherapy/Radiation
4 Chlorogenic acid
4 Indole-3-carbinol
4 Inulin Prebiotic
4 Ivermectin
4 Matrine
4 Quercetin
4 Resveratrol
4 Selenium NanoParticles
3 Astragalus
3 Ashwagandha(Withaferin A)
3 Melatonin
3 beta-glucans
3 Betulinic acid
3 Benzyl isothiocyanate
3 Brucea javanica
3 brusatol
3 Capsaicin
3 Copper and Cu NanoParticles
3 Chlorella (Chlorella vulgaris)
3 Diindolylmethane
3 Disulfiram
3 Gallic acid
3 Gambogic Acid
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Vitamin C (Ascorbic Acid)
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 Spermidine
2 1,8-Cineole
2 Auranofin
2 Cisplatin
2 Allicin (mainly Garlic)
2 Artemisinin
2 Atorvastatin
2 Aloe anthraquinones
2 Baicalein
2 Berberine
2 Bifidobacterium
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Carvacrol
2 Camu camu
2 Chlorophyllin
2 Gemcitabine (Gemzar)
2 Cucurbitacin
2 Curcumin
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Formononetin
2 Fucoidan
2 Paclitaxel/Taxol
2 iodine
2 Licorice
2 Magnolol
2 mebendazole
2 Naringin
2 Phycocyanin
2 Psoralidin
2 α-Santalol/Sandalwood oil
2 Shikonin
2 Thymol-Thymus vulgaris
1 3-bromopyruvate
1 acetazolamide
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Gold NanoParticles
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 probiotics
1 Boswellia (frankincense)
1 Butyrate
1 Carnosic acid
1 Caffeine
1 Carnosine
1 Cannabidiol
1 Celastrol
1 Prebiotic
1 Choline
1 Cinnamon
1 Carica papaya leaf extract
1 Camptothecin
1 Crocetin
1 Carvone
1 Vitamin B1/Thiamine
1 Spirulina(Arthrospira/Limnospira)
1 Cyclopamine
1 Cynaropicrin
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 Bortezomib
1 Dipyridamole
1 Dandelion Root
1 Ellagic acid
1 Evodiamine
1 Ferulic acid
1 Ginkgolic acids
1 Geldanamycin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 HydroxyTyrosol
1 Hyperoside
1 capecitabine
1 Isorhamnetin
1 Lactobacillus
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Luteolin
1 Methylene blue
1 Honokiol
1 Mung Bean Sprouts
1 Modified Citrus Pectin
1 MCT oil
1 Magnetic Fields
1 Moringin
1 Moringa oleifera
1 Morin
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Oxygen, Hyperbaric
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Piperlongumine
1 Polyphenols
1 Pterostilbene
1 Radio Frequency
1 Rutin
1 salinomycin
1 Selenium
1 Chemotherapy
1 Sulforaphane (mainly Broccoli)
1 erastin
1 statins
1 Citric Acid
1 Terpinen-4-ol / Tea Tree Oil
1 tetrathiomolybdate
1 Turmerones
1 Urolithin
1 Vitexin
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:913  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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