CAIX/CA9 Cancer Research Results

CAIX/CA9, Carbonic Anhydrase IX: Click to Expand ⟱
Source:
Type:
CAIX (Carbonic Anhydrase IX) is a transmembrane enzyme that plays a crucial role in maintaining the pH balance in cells and their surroundings. In the context of cancer, CAIX has been found to be overexpressed in various types of tumors.
CAIX is overexpressed in cancer cells compared to normal cells. This overexpression is thought to contribute to the increased ability of cancer cells to survive and grow in hypoxic environments.

CA9 - Carbonic Anhydrase 9 / Carbonic Anhydrase IX

Abbreviation: CA9, CA IX

Type: Transmembrane carbonic anhydrase / pH-regulation enzyme / hypoxia-associated tumor marker

Function: CA9 encodes carbonic anhydrase IX, a cell-surface enzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. In hypoxic cells, CA IX helps maintain intracellular pH by supporting bicarbonate availability while promoting extracellular acidification. CA9 expression is strongly induced by HIF-1α and is widely used as a marker of tumor hypoxia.

Cancer: ↑ Frequently overexpressed in hypoxic regions of solid tumors and associated with tumor survival, extracellular acidification, invasion, metastasis, cancer stem-like phenotypes, treatment resistance, and poor prognosis. CA IX allows tumor cells to maintain a relatively alkaline intracellular environment despite high glycolytic acid production.

Favorable Direction in Cancer: ↓ CA9/CA IX expression or activity is generally favorable because it disrupts tumor pH homeostasis, reduces extracellular acidification, and can increase sensitivity to hypoxia and anticancer treatment.
Scientific Papers found: Click to Expand⟱
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, Synergy↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
9253- ISO, IH,    Progress in the antitumor molecular mechanisms of Isorhamnetin
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiTum↑, TumCP↓, Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, ChemoSen↑, PI3K↓, Akt↓, TumCCA↑, MAPK↓, TumCG↓, CDK2↑, PPARγ↑, PTEN↓, CAIX/CA9↓, Casp8↑, Casp9↑, Casp3↑, ROS↑, ER Stress↑, UPR↑, BAX↑, Cyt‑c↑, cl‑PARP↑, Bcl-2↓, MMP↓, N-cadherin↓, Vim↓, Snail↓, E-cadherin↑, EMT↓, MMP2↓, MMP9↓,
9251- ISO, IH,    Advances in Isorhamnetin Treatment of Malignant Tumors: Mechanisms and Applications
- Review, Var, NA
BioAv↑, RenoP↑, chemoP↑, *Ingr↝, *cardioP↑, *antiOx↑, *Stroke↓, *AntiThr↑, *neuroP↑, *cognitive↑, *memory↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *NRF2↑, *TNF-α↓, *NO↓, *IL1β↓, *ROS↓, TumCCA↑, TumCP↓, PI3K↓, Akt↓, MET↑, MMPs↓, MMP2↓, MMP9↓, mTOR↓, PPARγ↓, PTEN↓, CAIX/CA9↓, Cyt‑c↑, ROS↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, ChemoSen↑, chemoP↑, RenoP↑, BioAv↓,
9243- ISO, IH,    Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
Hif1a↓, GLUT1↓, LDHA↓, CAIX/CA9↓, PDK1 / PDPK1↓, ROS↓,
8147- Lae,    Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis
- in-vitro, Cerv, Ca9-22 - in-vitro, Cerv, HeLa
TumCP↓, Apoptosis↑, TumCCA↑, HK2↓, CAIX/CA9↓,
8554- Matr,    Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation
- in-vitro, PC, Capan1 - in-vitro, PC, MIA PaCa-2
TumCP↓, TumCCA↑, Apoptosis↑, CAIX/CA9↓, CAXII/CA12↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, Var, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX/CA9↓,
1509- SFN,    Combination therapy in combating cancer
- Review, Var, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, ChemoSen↑, PSA↓, P53↑, Hif1a↓, CAIX/CA9↓, chemoR↓, 5HT↓,
2125- TQ,    Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
- in-vitro, RCC, RCC4 - in-vitro, RCC, Caki-1
Hif1a↓, eff↝, uPAR↓, VEGF↓, CAIX/CA9↓, PDK1 / PDPK1↓, GLUT1↓, LDHA↓, Glycolysis↓, e-lactateProd↓, i-ATP↓,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 1,   NRF2↑, 1,   PYCR1↓, 1,   ROS↓, 1,   ROS↑, 4,   SOD↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

i-ATP↓, 1,   CAIX/CA9↓, 9,   CAIX/CA9↑, 1,   Glycolysis↓, 3,   HK2↓, 1,   e-lactateProd↓, 1,   LDHA↓, 3,   PDK1 / PDPK1↓, 2,   PKM2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 7,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   ERK↑, 1,   FGFR1↓, 1,   IGF-1R↓, 1,   JAK2↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   mTOR↓, 2,   PI3K↓, 4,   PTEN↓, 2,   PTEN↑, 1,   STAT3↓, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   miR-34a↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↑, 4,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↑, 1,   CDK4↓, 3,   CDK6↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   Ki-67↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,   TumCG↓, 1,   TumCG↑, 1,   TumCP↓, 7,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   E-cadherin↑, 2,   EMT↓, 2,   MET↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCMig↑, 1,   TumMeta↑, 1,   uPAR↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 4,   NO↓, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   MMP↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 1,   FOXP3↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 1,   MCT1↓, 1,   NF-kB↓, 2,   NK cell↑, 1,   PSA↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   PPARγ↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 5,   Dose∅, 1,   eff↑, 1,   eff↝, 1,   RadioS↑, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   chemoP↑, 2,   ChemoSideEff↓, 3,   OS↑, 1,   radioP↑, 1,   RenoP↑, 2,   TumW↓, 1,  
Total Targets: 128

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   cardioP↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   Stroke↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 22

Scientific Paper Hit Count for: CAIX/CA9, Carbonic Anhydrase IX
3 Isorhamnetin
1 Ferulic acid
1 Laetrile B17 Amygdalin
1 Matrine
1 Melatonin
1 Nimbolide
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:929  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page