GCLC Cancer Research Results
GCLC, Glutamate-Cysteine Ligase, Catalytic Subunit: Click to Expand ⟱
| Source: |
| Type: |
The GCLC gene (Glutamate-Cysteine Ligase, Catalytic Subunit) is a key regulator of glutathione synthesis, and its expression has been studied in various types of cancer.
GCLC gene has been found to be:
Amplified in 15% of breast cancer cases
Mutated in 5% of lung cancer cases
Deleted in 10% of prostate cancer cases
Methylated in 20% of colorectal cancer cases
|
Scientific Papers found: Click to Expand⟱
| - |
in-vivo, |
CRC, |
HCT116 |
|
|
|
- |
in-vitro, |
CRC, |
SW480 |
|
|
|
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,
| - |
in-vitro, |
Pca, |
DU145 |
|
|
|
- |
in-vitro, |
Nor, |
MEF |
|
|
|
NRF2↑, selectivity↑, NQO1↑, GCLC↑, HO-1↑, TumCP↓,
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
*antiOx↑, *Inflam↓, AntiCan↑, *ROS↓, *MDA↓, *GSH↓, *NRF2↑, *GPx↑, *GCLC↑, *GCLM↑,
*antiOx↑, *ROS↓, *GSH↑, *GCLC↑, *GSS↑, *Akt↑, *NRF2↑,
*COX2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,
Showing Research Papers: 1 to 7 of 7
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Ferroptosis↑, 1, GCLC↑, 2, GCLM↑, 1, HO-1↑, 1, NQO1↑, 1, NRF2↑, 1,
Metal & Cofactor Biology ⓘ
FTL↑, 1, STEAP3↑, 1,
Core Metabolism/Glycolysis ⓘ
ACSL5↑, 2, SAT1↑, 1,
Cell Death ⓘ
Casp9↑, 1, Ferroptosis↑, 1,
DNA Damage & Repair ⓘ
TP53↑, 1,
Proliferation, Differentiation & Cell State ⓘ
Wnt/(β-catenin)↓, 1,
Migration ⓘ
TumCP↓, 1,
Drug Metabolism & Resistance ⓘ
ChemoSen↑, 1, selectivity↑, 1,
Clinical Biomarkers ⓘ
TP53↑, 1,
Functional Outcomes ⓘ
AntiCan↑, 1,
Total Targets: 19
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 5, ARE↑, 1, Bil↑, 2, Catalase↑, 1, Fenton↓, 2, GCLC↑, 5, GCLM↑, 3, GPx↑, 1, GSH↓, 1, GSH↑, 1, GSS↑, 1, GSTA1↑, 2, HO-1↑, 3, lipid-P↓, 3, MDA↓, 3, NQO1↑, 3, NRF2↑, 4, ROS↓, 4, SOD↑, 2,
Metal & Cofactor Biology ⓘ
IronCh↑, 2,
Core Metabolism/Glycolysis ⓘ
NADPH↑, 1, PPARγ↑, 2,
Cell Death ⓘ
Akt↑, 1, p‑Akt↓, 1, iNOS↓, 2, JNK↓, 1, p‑MAPK?, 1, p‑MAPK↓, 1, p38↓, 1, p‑p38↓, 1,
Transcription & Epigenetics ⓘ
p‑cJun↓, 1,
Migration ⓘ
Ca+2↓, 2, VCAM-1↓, 2,
Immune & Inflammatory Signaling ⓘ
COX2↓, 3, ICAM-1↓, 2, IL1β↓, 2, IL6↓, 1, IL8↓, 1, Inflam↓, 4, NF-kB↓, 3, PGE2↓, 2, TLR4↓, 1, TNF-α↓, 2,
Synaptic & Neurotransmission ⓘ
BDNF↑, 1, ChAT↑, 1,
Protein Aggregation ⓘ
Aβ↓, 2, NLRP3↓, 2,
Drug Metabolism & Resistance ⓘ
Dose↝, 1, Half-Life↝, 1,
Clinical Biomarkers ⓘ
Bil↑, 2, GutMicro↑, 2, IL6↓, 1,
Functional Outcomes ⓘ
cognitive↑, 1, hepatoP↑, 2, memory↑, 1, neuroP↑, 2, radioP↑, 1, RenoP↑, 1, toxicity↓, 1,
Total Targets: 59
Scientific Paper Hit Count for: GCLC, Glutamate-Cysteine Ligase, Catalytic Subunit
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:966 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
Home Page