EP4/PTGER4 Cancer Research Results

EP4/PTGER4, Prostaglandin E2 receptor 4: Click to Expand ⟱
Source:
Type:
Also known as PTGER4
EP4 (Prostaglandin E2 receptor 4) - Inflammation-Driven Growth, Immune Suppression, and Metastasis
-is a receptor that plays a role in various cellular processes, including inflammation and cell growth. In cancer, EP4 has been implicated in tumor development and progression.

Overexpressed in: Colorectal, Breast, Lung, Prostate, Ovarian, GBM cancers(with poor prognosis).
Underexpressed in: Some types of renal cell carcinoma (correlated with improved overall survival).

EP4 appears to play a tumorigenic role in various types of cancer, and its expression levels can be used as a prognostic marker to predict patient outcomes.
Core Pro-Tumor Mechanisms
a. Proliferation and Survival
EP4 activation:
-Elevates cAMP/PKA and PI3K–AKT signaling
-Promotes cell survival and resistance to stress
-Cooperates with growth-factor pathways
b. Invasion and Metastasis
-EP4 enhances:
-EMT programs
-Cell migration and invasion
-Matrix remodeling and metastatic seeding
c. Angiogenesis
EP4 signaling increases:
-VEGF expression
-Endothelial migration and vessel formation
-Tumor perfusion


Scientific Papers found: Click to Expand⟱
7047- GA,    Gallic acid-conjugated 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone induces apoptosis and downregulates PI3K/Akt signaling through VEGFR-2 targeting in non-small cell lung cancer (NSCLC)
- in-vitro, NSCLC, A549
TumCP↓, selectivity↑, AKT1↓, EP4/PTGER4↓, PDK1↓, VEGFR2/KDR/Flk1↓,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2↓, PGE2↓, EP2↓, EP4/PTGER4↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   NRF2↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   PDK1↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   p27↑, 1,   p‑p38↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EP2↓, 1,   EP4/PTGER4↓, 2,   EP4/PTGER4↑, 1,   p‑GSK‐3β↓, 1,   p‑PI3K↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   selectivity↑, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EP4/PTGER4, Prostaglandin E2 receptor 4
1 Gallic acid
1 Resveratrol
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:970  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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