tbResList Print — ASA Aspirin -acetylsalicylic acid

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Product

ASA Aspirin -acetylsalicylic acid
Features: nonsteroidal anti-inflammatory drug (NSAID)
Description: <b>Aspirin</b> irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2. COX-2 normally produces prostanoids, most of which are proinflammatory.<br>
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-Aspirin irreversibly inhibits the enzyme cyclooxygenase-1 (COX-1). This inhibition reduces the production of thromboxane A₂, a potent promoter of platelet aggregation.<br>
-low-dose aspirin is frequently used for the prevention of cardiovascular events such as heart attacks and strokes in individuals at risk.<br>
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Pathway results for Effect on Cancer / Diseased Cells

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,  

Transcription & Epigenetics ⓘ

other∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

H3K27ac∅, 1,  

Migration ⓘ

AntiAg↑, 2,   Ki-67↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 2,   COX2↓, 1,   IL10↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   TNF-β↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

CTC↓, 1,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

TumW↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2024Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T CellsJiayu LiuPMC11302567https://pmc.ncbi.nlm.nih.gov/articles/PMC11302567/0
2022Aspirin Suppressed PD-L1 Expression through Suppressing KAT5 and Subsequently Inhibited PD-1 and PD-L1 Signaling to Attenuate OC DevelopmentXiyun XiaoPMC8983188https://pmc.ncbi.nlm.nih.gov/articles/PMC8983188/0
2014Aspirin inhibit platelet-induced epithelial-to-mesenchymal transition of circulating tumor cells (Review)XIAO-LIANG LOUPMC3990215https://pmc.ncbi.nlm.nih.gov/articles/PMC3990215/0
1997Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxisK Schrör9263351https://pubmed.ncbi.nlm.nih.gov/9263351/0
2017Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatmentHyung Joon JooPMC5943656https://pmc.ncbi.nlm.nih.gov/articles/PMC5943656/0
2006Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 productionEduardo Candelario-Jalil16529823https://pubmed.ncbi.nlm.nih.gov/16529823/0