tbResList Print — EPI epirubicin

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Product

EPI epirubicin
Description: <b>Epirubicin</b>, an anthracycline chemotherapeutic agent, has several mechanisms of action, one of which is the production of reactive oxygen species (ROS). Here are some key points regarding epirubicin and its relationship with ROS:<br>
Mechanism of Action and ROS Generation<br>
-Epirubicin exerts its anticancer effects primarily by intercalating into DNA and inhibiting topoisomerase II, leading to DNA strand breaks.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress

ROS↑, 1,  

Cell Death

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,  

DNA Damage & Repair

P53↑, 1,  

Cell Cycle & Senescence

P21↑, 1,   TumCCA↑, 1,  

Drug Metabolism & Resistance

ChemoSen↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2017Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrestYumin Zhuo27719740https://pubmed.ncbi.nlm.nih.gov/27719740/0