tbResList Print — Lae Laetrile B17 Amygdalin

Features: Sourced from apricot kernels

Description: <b>Banned</b> in some states. May cause cyanide poisoning.<br>
Laetrile B17 (Amygdalin )<br>
Summary:<br>
-Activation of the caspase-3 protease and downregulating Bcl-2, upregulates BAX<br>
-Bax-to-Bcl-2 ratio and caspase-3 activity were increased<br>
-Inhibits NF-kβ and NLRP3 signaling pathways<br>
-Release of cyanide through the decomposition of amygdalin by the gut microfloral B-glucosidase enzyme. (bad)<br>
-IV might be better to avoid the digestive tract which could convert to hydrogen cyanide.????<br>
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Selective Toxicity (some challenges to this statement)<br>
The amygdalin itself is not toxic, but the HCN released from it causes the amygdalin toxic effect [35]. Cancer cells are dominant in anaerobic glycolysis and β -glucosidase is at its highest activity in lactate-induced acidic conditions [36]. Therefore, cancer cells have a high level of the unlocking enzyme β -glucosidase activity that breaks down amygdalin, leading to the release of HCN
On the other hand, normal cells are normo-oxygenated and contain low levels of the β -glucosidase enzyme as well as high levels of rhodanese enzyme which transforms hydrogen cyanide into harmless thiocyanate [46, 47]. Thiocyanate has positive effects on organisms such as lowering blood pressure and is also considered a precursor for vitamin B12.<br>
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It is poisonous when combined with plant-rich beta-glucosidase.<br>
Upon ingestion, amygdalin is hydrolyzed to cyanide by beta-glucuronidase in the small intestine [2]. Oral intake of 500 mg of amygdalin may contain as much as 30 mg of cyanide [3]. Oral amygdalin is estimated to be 40 times more potent than intravenous form due to its enzymatic conversion to hydrogen cyanide in the gastrointestinal tract [4]. <br>