tbResList Print — LE Licorice

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Product

LE Licorice
Description: <b>Glycyrrhizic acid (GA)</b> is a significant constituent of licorice root.<br>
Glycyrrhizin, the main active component obtained from licorice roots, has many pharmacological and biological functions such as protecting liver cells, anti-inflammation, anti-virus, immunomodulation, has been widely applied in the treatment of clinically related hepatic diseases (Dastagir & Rizvi, 2016). Glycyrrhizin is a natural inhibitor of HMGB1<br>

Pathway results for Effect on Cancer / Diseased Cells

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   HK2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   PI3K↓, 1,   TumCG↑, 1,  

Migration ⓘ

PKCδ↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   LOX1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   HMGB1↓, 1,   Inflam↓, 1,   PD-L1↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   PD-L1↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   TumVol↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2023The Promoting Role of HK II in Tumor Development and the Research Progress of Its InhibitorsBingru Liu—https://www.mdpi.com/1420-3049/29/1/750
2021Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltrationJinglin ZhuPMC8507331https://pmc.ncbi.nlm.nih.gov/articles/PMC8507331/0
2020Glycyrrhizin suppresses epithelial-mesenchymal transition by inhibiting high-mobility group box1 via the TGF-β1/Smad2/3 pathway in lung epithelial cellsYanni GuiPMC7003690https://pmc.ncbi.nlm.nih.gov/articles/PMC7003690/0
2007Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra rootSijun Dong17664038https://pubmed.ncbi.nlm.nih.gov/17664038/1
2004Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cellEun-Hye Jo15030235https://pubmed.ncbi.nlm.nih.gov/15030235/0
2001Licorice and cancerZ Y Wang11588889https://pubmed.ncbi.nlm.nih.gov/11588889/0