tbResList Print — OA Oroxylin-A

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Product

OA Oroxylin-A
Description: <b>O-methylated flavone</b>, a chemical compound that can be found in the medicinal plants Scutellaria baicalensis [1] and Scutellaria lateriflora, [2] [3] and the Oroxylum indicum tree. [4]<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

SIRT3↑, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis ⓘ

FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   NPC1L1↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  
Total Targets: 8

Research papers

Year Title Authors PMID Link Flag
2019Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cellsFeixia WangPMC6371416https://pmc.ncbi.nlm.nih.gov/articles/PMC6371416/0
2018Review of the Clinical Effect of OrlistatXiguang Qi—https://www.researchgate.net/publication/323160262_Review_of_the_Clinical_Effect_of_Orlistat0
2015Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilizationL WeiPMC4650553https://pmc.ncbi.nlm.nih.gov/articles/PMC4650553/0