tbResList Print — Se Selenium

Filters: qv=149, qv2=%, rfv=%

Product

Se Selenium
Features: micronutrient
Description: <b>Naturally</b> occurring element. Selenium is incorporated into selenoproteins, such as glutathione peroxidases (GPxs) and thioredoxin reductases (TrxRs), which play critical roles in protecting cells from oxidative damage.<br>
Involved in GPx, TrxR, ans Selenoprotien P which protect normal cells from oxidative stress.<br>
Important in Thyroid hormone metabolism, immune system regulation, reproductive health, and Brain and heart protection. <br>
<br>
-recommended daily allowance (RDA) for selenium is about 55 µg/day for adults. (upper tolerance 400ug/day)<br>
-One Brazil nut may contain 50-300ug/nut<br>
<br>
Sodium selenite (Na₂SeO₃) is a selenium compound with well-documented anticancer and chemopreventive properties<br>
-Oxidation state: +4 (selenite form of selenium)<br>
-Type: Inorganic selenium compound (water-soluble)<br>
<br>
-Sodium selenite generates reactive oxygen species (ROS) selectively in tumor cells.<br>
-Induces cytochrome c release, caspase-3 activation, and DNA fragmentation.<br>
-Reduces VEGF expression and endothelial cell migration.<br>
-Blocks cell division at G2/M phase<br>
-Suppresses MMP-2 and MMP-9 activity<br>
-Activates p53<br>
-Inhibits NF-κB<br>
-PI3K/Akt/mTOR Suppression<br>
-Inactivation of Thioredoxin/Glutathione systems<br>


-NRF2 inhibition in cancer cell might be connected with <a href="https://nestronics.ca/dbx/tbResEdit.php?rid=4726">O2 level</a><br>

<br>
Narrow therapeutic window:<br>
-Low micromolar (≤5 µM) → anticancer<br>
-High (>10 µM) → toxic to normal cells<br>
<br>
Some Selenium Supplements use Sodium Selenite as the active ingredient.<br>
- NOW Foods Selenium, Nature's Bounty Selenium, etc<br>
<br>
Other common form is Selenomethionine, as it is better absorbed (found in brazil nuts),
but might be less effective?<br>

<pre>
| Category | Role in cancer |
| -------------------------------- | ----------------------------------------------------------------------------------------------- |
| Sodium Selenium (selenite) | Direct cytotoxic redox poison |
| Selenium (organic / nutritional) | **Redox buffer & immune modulator** (generally *anti-therapy* when oxidative stress is desired) |
| SeNPs | Tunable redox-signaling anticancer platform |
</pre>



<br>
Selenium (Organic / Nutritional) — Cancer-Relevant Pathways<br>

<table border="1" cellspacing="0" cellpadding="4">
<tr>
<th>Rank</th>
<th>Pathway / Target Axis</th>
<th>Direction</th>
<th>Primary Effect</th>
<th>Notes / Cancer Relevance</th>
<th>Ref</th>
</tr>

<tr>
<td>1</td>
<td>Selenoprotein antioxidant systems (GPX1–4, TXNRD)</td>
<td>↑ antioxidant capacity</td>
<td>ROS buffering</td>
<td>Dietary selenium increases glutathione peroxidase and thioredoxin reductase activity, lowering oxidative stress</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/18397740/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>2</td>
<td>Glutathione redox cycling (GSH/GSSG)</td>
<td>↑ GSH recycling</td>
<td>Redox homeostasis</td>
<td>Selenium supports GPX-mediated peroxide detoxification and preserves cellular GSH pools</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/24094452/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>3</td>
<td>Ferroptosis suppression (GPX4 axis)</td>
<td>↓ ferroptosis susceptibility</td>
<td>Lipid peroxide detoxification</td>
<td>GPX4 is a selenoprotein; adequate selenium suppresses lipid peroxidation and ferroptotic death</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/27277574/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>4</td>
<td>NRF2 antioxidant response</td>
<td>↔ / ↑ (supportive)</td>
<td>Stress adaptation</td>
<td>Selenium status influences NRF2 target gene expression indirectly via redox tone</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/30138649/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>5</td>
<td>DNA damage prevention / repair environment</td>
<td>↓ oxidative DNA damage</td>
<td>Genomic stability</td>
<td>Selenium sufficiency reduces oxidative DNA lesions and supports repair capacity</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/21513830/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>6</td>
<td>p53 redox regulation</td>
<td>↔ stabilized (context-dependent)</td>
<td>Checkpoint fidelity</td>
<td>Redox balance maintained by selenium supports normal p53 signaling rather than triggering apoptosis</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/19028618/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>7</td>
<td>NF-κB inflammatory signaling</td>
<td>↓ chronic activation</td>
<td>Anti-inflammatory bias</td>
<td>Selenium supplementation suppresses NF-κB activation under inflammatory/oxidative conditions</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/20061387/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>8</td>
<td>Immune competence (T-cell, NK-cell function)</td>
<td>↑ immune function</td>
<td>Improved immune surveillance</td>
<td>Selenium supports cytotoxic lymphocyte activity and cytokine balance</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/20110593/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>9</td>
<td>Angiogenesis signaling (VEGF)</td>
<td>↔ / mild ↓</td>
<td>Vascular normalization</td>
<td>Nutritional selenium does not strongly inhibit angiogenesis but may modestly reduce VEGF under stress</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/19811770/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>10</td>
<td>PI3K–AKT survival signaling</td>
<td>↔ (homeostatic)</td>
<td>Cell survival maintenance</td>
<td>Unlike selenite or SeNPs, organic selenium does not directly suppress PI3K–AKT at nutritional doses</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/24743092/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>11</td>
<td>Autophagy (baseline maintenance)</td>
<td>↔</td>
<td>Cellular homeostasis</td>
<td>Selenium supports basal autophagy via redox balance but does not drive cytotoxic autophagy</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/31445555/" target="_blank">(ref)</a></td>
</tr>

<tr>
<td>12</td>
<td>Cancer risk modulation (epidemiologic)</td>
<td>↓ risk in deficient populations</td>
<td>Prevention (not treatment)</td>
<td>Protective effects are context-dependent; excess selenium may be neutral or adverse in replete populations</td>
<td><a href="https://pubmed.ncbi.nlm.nih.gov/19622715/" target="_blank">(ref)</a></td>
</tr>
</table>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx↑, 1,   GSH↓, 2,   GSH⇅, 1,   H2O2↑, 1,   HO-1↓, 1,   lipid-P↑, 1,   NRF2↑, 1,   NRF2↝, 2,   NRF2↓, 3,   Prx↓, 1,   ROS↑, 7,   ROS⇅, 1,   selenoP↓, 1,   selenoP↑, 2,   SOD↓, 1,   Trx↓, 1,   TrxR↓, 1,   TrxR↑, 1,  

Metal & Cofactor Biology ⓘ

selm↑, 1,   selm↝, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 4,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   BUN↓, 1,   LDH↓, 1,   NADPH↓, 1,  

Cell Death ⓘ

Apoptosis↑, 8,   BAX↑, 2,   Bcl-2↓, 2,   Casp↑, 2,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   FADD↑, 2,   Fas↑, 2,   FasL↑, 2,   Ferroptosis↑, 1,   MAPK↑, 1,   p‑p38↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 6,   other∅, 1,   tumCV↓, 3,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   RAD51↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

TumCP↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,  

Cellular Microenvironment ⓘ

e-pH↓, 1,   pH∅, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   ChemoSen↓, 1,   ChemoSen∅, 1,   Dose∅, 2,   Dose↓, 3,   Dose↑, 2,   Dose↝, 10,   eff↑, 10,   eff↓, 3,   eff∅, 1,   eff↝, 6,   RadioS↑, 1,   RadioS↓, 1,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 1,   AST↓, 1,   creat↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   chemoP↑, 9,   chemoPv↑, 1,   OS↑, 6,   Pain↓, 1,   QoL↑, 1,   radioP↑, 3,   Risk↓, 21,   Risk↑, 1,   Risk∅, 1,   Risk↝, 2,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 94

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

antiOx↑, 6,   Catalase↑, 1,   GPx↑, 5,   GPx1↑, 2,   GPx4↑, 1,   GSH↑, 7,   GSTP1/GSTπ↓, 1,   H2O2↓, 1,   HDL↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 7,   NRF2↓, 2,   Prx↑, 1,   ROS↓, 6,   selenoP↑, 4,   SOD↑, 3,   SOD2↓, 1,   TrxR↑, 1,   TrxR1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   LDL↓, 1,   PPARγ↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,   other↝, 1,   other∅, 1,   other?, 2,  

Autophagy & Lysosomes ⓘ

ATG5↓, 1,   Beclin-1↓, 1,   LC3s↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↑, 1,  

Migration ⓘ

TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL2↑, 1,   IL2↓, 1,   IL4↑, 1,   IL6↓, 2,   Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,   BDNF↑, 1,   TrkB↑, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   Dose↝, 3,   eff↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 2,   AST↓, 1,   BP↓, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 1,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↝, 1,   Risk↓, 1,   toxicity↝, 1,   toxicity↑, 1,   toxicity↓, 3,  
Total Targets: 80

Research papers

Year Title Authors PMID Link Flag
2022Using Supplements During Chemo: Yes or No?Karen Sabbath, MS, RD, CSO—https://www.leevercancercenter.org/blog/using-supplements-during-chemo-yes-or-no/0
2024The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in ratsMustafa CengizPMC11481652https://pmc.ncbi.nlm.nih.gov/articles/PMC11481652/0
2020A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathwayJiayue Gao32387597https://pubmed.ncbi.nlm.nih.gov/32387597/0
2015Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapyInês L Martins25906385https://pubmed.ncbi.nlm.nih.gov/25906385/0
2018Coenzyme Q10 Supplementation in Aging and DiseaseJuan D. Hernández-Camacho—https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00044/full0
2013Antioxidant effects of green teaSARAH C FORESTERPMC3679539https://pmc.ncbi.nlm.nih.gov/articles/PMC3679539/0
2006Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activityJonathan D.H. Morris—https://www.sciencedirect.com/science/article/abs/pii/S0304383505007433?via%3Dihub0
2025Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathwayYu Liu39837256https://pubmed.ncbi.nlm.nih.gov/39837256/0
2025Anti-cancer potential of chitosan-starch selenium Nanocomposite: Targeting osteoblastoma and insights of molecular dockingSowmya R—https://www.sciencedirect.com/science/article/abs/pii/S0006291X250056740
2025The ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino ratsOmnia E. Shalaby—https://link.springer.com/content/pdf/10.1186/s13048-024-01577-z.pdf0
2025Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancerJaewang Lee—https://link.springer.com/article/10.1007/s00109-025-02563-80
2025Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfiteRadosveta Gencheva—https://www.sciencedirect.com/science/article/pii/S08915849250019960
2025Selenium in cancer management: exploring the therapeutic potentialLingwen He—https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1490740/full0
2024A systematic review of Selenium as a complementary treatment in cancer patientsFelix Krannich—https://www.sciencedirect.com/science/article/pii/S09652299240008390
2024Effect of Selenium and Selenoproteins on Radiation ResistanceShidi Zhang—https://www.mdpi.com/2072-6643/16/17/29020
2024Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative StudyMichał ChalcarzPMC10962284https://pmc.ncbi.nlm.nih.gov/articles/PMC10962284/0
2024A U-shaped association between selenium intake and cancer riskNgoan Tran Le—https://www.nature.com/articles/s41598-024-66553-50
2023An Assessment of Serum Selenium Concentration in Women with Ovarian CancerMarek KluzaPMC9963663https://pmc.ncbi.nlm.nih.gov/articles/PMC9963663/0
2023Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinomaCheng Wang—https://www.sciencedirect.com/science/article/pii/S10436618220057090
2023Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cellsHaixi Zhang—https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.234240
2023Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort studyDavid J Hughes37923090https://pubmed.ncbi.nlm.nih.gov/37923090/0
2023The effect of selenium yeast in the prevention of adverse reactions related to platinum-based combination therapy in patients with malignant tumorsM Chen37975373https://pubmed.ncbi.nlm.nih.gov/37975373/0
2022Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein AnalysisSu-Jun SunPMC9716935https://pmc.ncbi.nlm.nih.gov/articles/PMC9716935/0
2022Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilersJingqiu WangPMC9719864https://pmc.ncbi.nlm.nih.gov/articles/PMC9719864/0
2022Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 PathwayHai-Bing Yang—https://link.springer.com/article/10.1007/s12011-021-02891-z0
2022Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in ratsCheng LiPMC9280227https://pmc.ncbi.nlm.nih.gov/articles/PMC9280227/0
2022Selenium and cancer risk: Wide-angled Mendelian randomization analysisShuai YuanPMC7613914https://pmc.ncbi.nlm.nih.gov/articles/PMC7613914/0
2022Selenium and breast cancer - An update of clinical and epidemiological dataBrenna Flowers36379313https://pubmed.ncbi.nlm.nih.gov/36379313/0
2022Selenium dietary intake and survival among CRC patientsMalgorzata Augustyniak36176217https://pubmed.ncbi.nlm.nih.gov/36176217/0
2022Role of micronutrients in Alzheimer's disease: Review of available evidenceHong-Xin FeiPMC9372870https://pmc.ncbi.nlm.nih.gov/articles/PMC9372870/0
2022An Assessment of Serum Selenium Concentration in Women with Endometrial CancerMagdalena JanowskaPMC8912795https://pmc.ncbi.nlm.nih.gov/articles/PMC8912795/0
2022Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor CancersBriana K ShimadaPMC9687593https://pmc.ncbi.nlm.nih.gov/articles/PMC9687593/0
2021Selenium stimulates the antitumour immunity: Insights to future researchAli Razaghi—https://www.ejcancer.com/article/S0959-8049(21)00462-7/fulltext0
2021Serum Selenium Level and 10-Year Survival after MelanomaEmilia Rogoża-JaniszewskaPMC8392027https://pmc.ncbi.nlm.nih.gov/articles/PMC8392027/0
2020Nrf2-modulation by seleno-hormetic agents and its potential for radiation protectionDesirée Bartolini31617634https://pubmed.ncbi.nlm.nih.gov/31617634/0
2020Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control StudyHong Luo32777945https://pubmed.ncbi.nlm.nih.gov/32777945/0
2019Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium StatusVeronika FedirkoPMC6520820https://pmc.ncbi.nlm.nih.gov/articles/PMC6520820/0
2019Selenium as an adjuvant for modification of radiation responseBagher Farhood31190419https://pubmed.ncbi.nlm.nih.gov/31190419/0
2018The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood CellsRichard J LobbPMC6214079https://pmc.ncbi.nlm.nih.gov/articles/PMC6214079/0
2018Phase I trial of selenium plus chemotherapy in gynecologic cancersMihae Song—https://www.gynecologiconcology-online.net/article/S0090-8258(18)31014-X/addons0
2018Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal CancerDavid J HughesPMC6266908https://pmc.ncbi.nlm.nih.gov/articles/PMC6266908/0
2018Selenium and Selenoproteins in Gut Inflammation—A ReviewShaneice K NettlefordPMC5874522https://pmc.ncbi.nlm.nih.gov/articles/PMC5874522/0
2018Selenium status and survival from colorectal cancer in the European prospective investigation of cancer and nutritionD. Hughes—https://www.sciencedirect.com/science/article/pii/S0398762018308423?via%3Dihub0
2017Vegetarianism and colorectal cancer risk in a low-selenium environment: effect modification by selenium status? A possible factor contributing to the null results in British vegetariansJakub G SobieckiPMC5534195https://pmc.ncbi.nlm.nih.gov/articles/PMC5534195/0
2017Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American WomenPaul D TerryPMC5368582https://pmc.ncbi.nlm.nih.gov/articles/PMC5368582/0
2016Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regressionXianlei Cai—https://www.nature.com/articles/srep192130
2015Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cellsYichong Wang26094214https://pubmed.ncbi.nlm.nih.gov/26094214/0
2015Association between plasma selenium level and NRF2 target genes expression in humansEdyta Reszka—https://www.sciencedirect.com/science/article/abs/pii/S0946672X140025080
2014Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohortDavid J Hughes25042282https://pubmed.ncbi.nlm.nih.gov/25042282/0
2014Selenium and cancer: a story that should not be forgotten-insights from genomicsCatherine Méplan24114479https://pubmed.ncbi.nlm.nih.gov/24114479/0
2013Chapter Four - Selenium in the Redox Regulation of the Nrf2 and the Wnt PathwayRegina Brigelius-Flohé—https://www.sciencedirect.com/science/chapter/bookseries/abs/pii/B97801240588280000400
2012Association of selenium status and blood glutathione concentrations in blacks and whitesJohn P Richie Jr—https://pmc.ncbi.nlm.nih.gov/articles/PMC3087599/0
2012The influence of selenium and selenoprotein gene variants on colorectal cancer riskCatherine Méplan22294765https://pubmed.ncbi.nlm.nih.gov/22294765/0
2012The Yin and Yang of Nrf2-Regulated Selenoproteins in CarcinogenesisRegina Brigelius-FlohéPMC3357939https://pmc.ncbi.nlm.nih.gov/articles/PMC3357939/0
2010Ingestion of selenium and other antioxidants during prostate cancer radiotherapy: A good thing?A. Tabassum—https://www.cancertreatmentreviews.com/article/S0305-7372(09)00190-X/abstract0
2009Selenium Prevention of Alopecia, Bladder and Kidney Toxicity Induced by Chemotherapeutic AgentsRoswell Park Comprehensive Cancer Center—https://www.roswellpark.org/commercialization/technologies/selenium-prevention-alopecia-bladder-kidney-toxicity-induced0
2007Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer TherapyKim Yun-Jeong—https://www.researchgate.net/publication/26529638_Targeting_the_Nrf2-Prx1_Pathway_with_Selenium_to_Enhance_the_Efficacy_and_Selectivity_of_Cancer_Therapy0
2007Selenium in cancer prevention: a review of the evidence and mechanism of actionMargaret P. Rayman—https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/selenium-in-cancer-prevention-a-review-of-the-evidence-and-mechanism-of-action/4513FC73B7861A08AF6E98355715BC5D0
2005Selenium Protects Against Toxicity Induced by Anticancer Drugs and Augments Antitumor Activity: A Highly Selective, New, and Novel Approach for the Treatment of Solid TumorsMarwan Fakih—https://www.clinical-colorectal-cancer.com/article/S1533-0028(11)70177-3/abstract0
2004Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapyKrzysztof Sieja15099940https://pubmed.ncbi.nlm.nih.gov/15099940/0
1997The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patientsYa-Jun Hu—https://link.springer.com/article/10.1007/BF027853040
1995Prospective study of toenail selenium levels and cancer among womenM Garland7707436https://pubmed.ncbi.nlm.nih.gov/7707436/0
2001Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell lineWeixiong Zhong—https://www.researchgate.net/publication/11763422_Redox-mediated_effects_of_selenium_on_apoptosis_and_cell_cycle_in_the_LNCaP_human_prostate_cancer_cell_line0
2013Vitamin C and Cancer: Is There A Use For Oral Vitamin C?Steve Hickey, PhD—https://isom.ca/article/vitamin-c-cancer-use-oral-vitamin-c/0