tbResList Print — GSL Siegesbeckia glabrescens

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Product

GSL Siegesbeckia glabrescens
Description: <b>Germacranolide sesquiterpene lactone (GSL)</b> was isolated from Siegesbeckia glabrescens as an inhibitor of Gli. <br>

Pathway results for Effect on Cancer / Diseased Cells

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Gli1↓, 1,   HH↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PGE2↓, 1,  
Total Targets: 6

Research papers

Year Title Authors PMID Link Flag
2016A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cellsHwa Jin LeePMC5038360https://pmc.ncbi.nlm.nih.gov/articles/PMC5038360/0
2011In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescensHua Li21308823https://pubmed.ncbi.nlm.nih.gov/21308823/0