tbResList Print — TV Thymol-Thymus vulgaris

Filters: qv=161, qv2=%, rfv=%

Product

TV Thymol-Thymus vulgaris
Description: <b>Thyme</b><br>
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Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

GSH↓, 1,   H2O2↑, 1,   lipid-P↑, 1,   MDA↑, 1,   MDA↓, 1,   ROS↑, 5,   i-ROS↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 3,   MPT↑, 2,  

Core Metabolism/Glycolysis ⓘ

PIK3CA↓, 1,  

Cell Death ⓘ

Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 5,   BAD↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 2,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 2,   Cyt‑c↑, 4,   FasL↑, 1,   p‑JNK↑, 1,   JNK↑, 1,   MAPK↓, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   cl‑PARP↑, 3,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 2,   Gli1↓, 1,   mTOR↓, 2,   NOTCH↓, 1,   PI3K↓, 3,   Smo↓, 1,   TRPM7↓, 2,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

5LO↓, 1,   AXL↓, 1,   Ca+2↑, 2,   F-actin↓, 1,   MMP2↓, 2,   MMP9↓, 2,   PKCδ↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 2,   BioAv↑, 3,   ChemoSen↑, 2,   eff↑, 4,   eff↝, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AFP↓, 1,   EGFR↓, 1,   GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   chemoP↑, 1,   hepatoP↑, 1,   radioP↑, 1,   RenoP↑, 1,   TumVol↓, 1,   Weight↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 78

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

antiOx↑, 5,   Catalase↑, 2,   GPx↑, 3,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NADH↓, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 1,   SOD↑, 3,   TAC↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   LDH↓, 1,   LDL↓, 1,   NADPH↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↓, 1,  

Migration ⓘ

AntiAg↑, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

GastroP↑, 1,   IBI↑, 1,   OCLN↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX1↑, 1,   COX2↓, 1,   IL1β↓, 2,   Imm↑, 1,   Inflam↓, 5,   Inflam↑, 1,   NF-kB↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↝, 1,   BioAv↑, 2,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BP↓, 1,   GutMicro↑, 1,   LDH↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 3,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 2,   Obesity↓, 1,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 4,  
Total Targets: 65

Research papers

Year Title Authors PMID Link Flag
2026Combined Cytotoxic Effects of Carvacrol-Based Essential Oil FormulationsÖykü Gönül GeyikPMC12844670https://pmc.ncbi.nlm.nih.gov/articles/PMC12844670/0
2025Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer ManagementAhmad Mujtaba NomanPMC12436185https://pmc.ncbi.nlm.nih.gov/articles/PMC12436185/0
2025Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and CarvacrolRocco LatorrePMC12651208https://pmc.ncbi.nlm.nih.gov/articles/PMC12651208/0
2024Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial TherapeuticsSijongesonke PeterPMC11123974https://pmc.ncbi.nlm.nih.gov/articles/PMC11123974/0
2024Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer LinesMohamed TaibiPMC11355195https://pmc.ncbi.nlm.nih.gov/articles/PMC11355195/0
2021Antitumor Effects of Carvacrol and Thymol: A Systematic ReviewLaeza Alves SampaioPMC8293693https://pmc.ncbi.nlm.nih.gov/articles/PMC8293693/0
1987Metabolism in rats of p-cymene derivatives: carvacrol and thymolL T Austgulen2959918https://pubmed.ncbi.nlm.nih.gov/2959918/0
2022Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological PropertiesYao Liu—https://www.mdpi.com/2076-3921/11/10/19470
2020Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin PathwayQiongyao Zeng—https://www.researchgate.net/publication/342606646_Thymol_Isolated_from_Thymus_vulgaris_L_Inhibits_Colorectal_Cancer_Cell_Growth_and_Metastasis_by_Suppressing_the_Wntb-Catenin_Pathway0
2017Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical DevelopmentMohamed Fizur Nagoor MeeranPMC5483461https://pmc.ncbi.nlm.nih.gov/articles/PMC5483461/0
2016Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringensEncun Du—https://link.springer.com/article/10.1186/s40104-016-0079-70