tbResList Print — MF Magnetic Fields

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Product

MF Magnetic Fields
Features: Therapy
Description: <p><b>Magnetic Fields</b> — externally applied static or time-varying magnetic fields used to alter cellular signaling, redox state, ion handling, membrane behavior, metabolism, or neural activity without introducing a chemical agent. They are a physical therapeutic modality and include static magnetic fields (SMF), extremely-low-frequency magnetic fields (ELF-MF), pulsed electromagnetic fields (PEMF), and other non-rotating oscillating/time-varying magnetic fields. Common abbreviations include MF, SMF, ELF-MF, EMF, and PEMF. Biological effects are strongly dependent on field strength, frequency, waveform, gradient, duty cycle, exposure duration, and tissue or cell type. Rotating magnetic fields are excluded here because they are represented separately as pid 192; magnetic-nanoparticle-dependent magnetothermal or magnetomechanical effects are also better assigned primarily to the magnetic nanoparticle product.</p>

<p><b>Primary mechanisms (ranked):</b></p>
<ol>
<li>Redox modulation and ROS perturbation, including radical-pair and mitochondrial mechanisms; cancer cells may develop sustained oxidative stress whereas normal cells frequently show adaptive antioxidant responses.</li>
<li>Ca²⁺ and ion-channel modulation, particularly TRPC, voltage-gated channels, intracellular Ca²⁺ handling, and ER–mitochondrial Ca²⁺ communication.</li>
<li>Mitochondrial and bioenergetic modulation, including membrane potential, electron transport, ATP production, mitochondrial permeability, and metabolic reprogramming.</li>
<li>Cell proliferation, cell-cycle, apoptosis, and senescence signaling through pathways including EGFR/PI3K/AKT/mTOR, MAPK/ERK, caspases, PARP, Bax and survivin.</li>
<li>Membrane permeability and drug-uptake modulation, producing context-dependent chemosensitization to agents including doxorubicin, etoposide and methotrexate.</li>
<li>Inflammatory and stress-response modulation including NF-κB, cytokine signaling, HSPs, ER stress and adaptive antioxidant pathways.</li>
<li>Migration, invasion, angiogenesis and tumor-microenvironment modulation; effects are field-parameter and tumor-model dependent.</li>
</ol>

<p><b>Bioavailability / PK relevance:</b> Conventional pharmacokinetic concepts do not apply because the intervention is a physical field rather than an absorbed drug. Relevant exposure variables are magnetic flux density, field gradient, frequency, waveform, pulse width, repetition rate, duty cycle, spatial distribution, treatment duration and tissue depth. Magnetic fields can penetrate tissue without the concentration gradients characteristic of drugs, but induced electric fields and biological coupling vary markedly with geometry and frequency.</p>

<p><b>In-vitro vs systemic exposure relevance:</b> Effects are not concentration-driven. Many experimental results cannot be generalized between devices because apparently small differences in waveform, frequency, flux density, orientation, gradient and exposure duration can change the biological response. Static fields ranging from millitesla to tesla and PEMF/ELF protocols ranging from weak fields to substantially stronger stimulation should therefore be treated as distinct exposure regimens rather than as a single dose-response continuum.</p>

<p><b>Clinical evidence status:</b> Cancer treatment remains predominantly preclinical, with cell-culture and animal evidence plus limited supportive or adjunctive human use. Evidence supports parameter-dependent anticancer effects and chemosensitization, but non-rotating magnetic-field exposure alone is not an established standard anticancer therapy. PEMF has established clinical use in several musculoskeletal applications and has been studied as supportive therapy in oncology. Repetitive transcranial magnetic stimulation has substantially stronger human evidence in neurological and psychiatric applications, including investigational use in Alzheimer’s disease, but should not be interpreted as evidence that generic magnetic-field exposure is an established systemic cancer treatment.</p>


<b>Magnetic Fields</b> can be Static, or pulsed. The most common therapy is a pulsed magnetic field in the uT or mT range.<br>
The main pathways affected are:<br>
Calcium Signaling: -influence the activity of voltage-gated calcium channels.<br>
Oxidative Stress and Reactive Oxygen Species (ROS) Pathways<br>
Heat Shock Proteins (HSPs) and Cellular Stress Responses<br>
Cell Proliferation and Growth Signaling: MAPK/ERK pathway.<br>
Gene Expression and Epigenetic Modifications: NF-κB<br>
Angiogenesis Pathways: VEGF (improving VEGF for normal cells)<br>
PEMF was found to have a 2-fold increase in drug uptake compared to traditional electrochemotherapy in rat melanoma models<br>

<br>
Pathways:<br>

<!-- ROS : MMP↓, ER Stress↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, UPR↑, cl-PARP↑-->
- most reports have
<a href="tbResList.php?qv=172&tsv=275&wNotes=on">ROS</a> production increasing in cancer cells
, while decreasing in normal cells.<br>
- ROS↑ related:
<a href="tbResList.php?qv=172&tsv=197&wNotes=on&word=MMP↓">MMP↓</a>(ΔΨm),
<a href="tbResList.php?qv=172&tsv=103&wNotes=on">ER Stress↑</a>,
<a href="tbResList.php?qv=172&tsv=459&wNotes=on">UPR↑</a>,
<a href="tbResList.php?qv=172&tsv=356&wNotes=on">GRP78↑</a>,
<a href="tbResList.php?qv=172&tsv=38&wNotes=on&word=Ca+2↑">Ca+2↑</a>,
<a href="tbResList.php?qv=172&tsv=77&wNotes=on">Cyt‑c↑</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=Casp">Caspases↑</a>,
<a href="tbResList.php?qv=172&tsv=82&wNotes=on&word=DNAdam↑">DNA damage↑</a>,
<a href="tbResList.php?qv=172&tsv=239&wNotes=on">cl-PARP↑</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=HSP">HSP↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=Prx">Prx</a>,<!-- mitochondrial antioxidant enzyme-->

<br>

<!-- ANTIOXIDANT : NRF2, SOD, GSH, CAT, HO-1, GPx, GPX4, -->
<!--
- Lowers AntiOxidant defense in Cancer Cells:
<a href="tbResList.php?qv=172&tsv=226&wNotes=on&word=NRF2↓">NRF2↓</a>,
<a href="tbResList.php?qv=172&word=Trx&wNotes=on">TrxR↓**</a>,
<a href="tbResList.php?qv=172&tsv=298&wNotes=on&word=SOD↓">SOD↓</a>,
<a href="tbResList.php?qv=172&tsv=137&wNotes=on&word=GSH↓">GSH↓</a>
<a href="tbResList.php?qv=172&tsv=46&wNotes=on">Catalase↓</a>
<a href="tbResList.php?qv=172&tsv=597&wNotes=on">HO1↓</a>
<a href="tbResList.php?qv=172&wNotes=on&word=GPx">GPx↓</a>
<br> -->

- Raises
<a href="tbResList.php?qv=172&tsv=1103&wNotes=on&word=antiOx↑">AntiOxidant</a>
defense in Normal Cells:
<a href="tbResList.php?qv=172&tsv=275&wNotes=on&word=ROS↓">ROS↓</a>,
<a href="tbResList.php?qv=172&tsv=226&wNotes=on&word=NRF2↑">NRF2↑</a>,
<a href="tbResList.php?qv=172&tsv=298&wNotes=on&word=SOD↑">SOD↑</a>,
<a href="tbResList.php?qv=172&tsv=137&wNotes=on&word=GSH↑">GSH↑</a>,
<a href="tbResList.php?qv=172&tsv=46&wNotes=on&word=Catalase↑">Catalase↑</a>,
<!-- genes involved in the oxidative stress-antioxidant defense system PRNP, NQO1, and GCLM -->
<br>

<!-- INFLAMMATION : NF-kB↓, COX2↓, COX2↓ PRO-INFL CYTOKINES: IL-1β↓, TNF-α↓, IL-6↓, IL-8↓, -->
- lowers
<a href="tbResList.php?qv=172&tsv=953&wNotes=on&word=Inflam">Inflammation</a> :
<a href="tbResList.php?qv=172&tsv=214&wNotes=on&word=NF-kB↓">NF-kB↓</a>,
<a href="tbResList.php?qv=172&tsv=66&wNotes=on&word=COX2↓">COX2↓</a>,
<!-- <a href="tbResList.php?qv=172&tsv=235&wNotes=on&word=p38↓">p38↓</a>, --> Pro-Inflammatory Cytokines :
<a href="tbResList.php?qv=172&tsv=908&wNotes=on&word=NLRP3↓">NLRP3↓</a>,
<a href="tbResList.php?qv=172&tsv=978&wNotes=on&word=IL1β↓">IL-1β↓</a>,
<a href="tbResList.php?qv=172&tsv=309&wNotes=on&word=TNF-α↓">TNF-α↓</a>,
<a href="tbResList.php?qv=172&tsv=158&wNotes=on&word=IL6↓">IL-6↓</a>,
<a href="tbResList.php?qv=172&tsv=368&wNotes=on&word=IL8↓">IL-8↓</a>
<br>



<!-- GROWTH/METASTASES : EMT↓, MMPs↓, MMP2↓, MMP9↓, IGF-1, uPA↓, VEGF↓, ERK↓
inhibiting metastasis-associated proteins such as ROCK1, FAK, (RhoA), NF-κB and u-PA, MMP-1 and MMP-13.-->
- inhibit Growth/Metastases :
<a href="tbResList.php?qv=172&tsv=604&wNotes=on">TumMeta↓</a>,
<a href="tbResList.php?qv=172&tsv=323&wNotes=on">TumCG↓</a>,
<!-- <a href="tbResList.php?qv=172&tsv=96&wNotes=on">EMT↓</a>,
<a href="tbResList.php?qv=172&tsv=204&wNotes=on">MMPs↓</a>,
<a href="tbResList.php?qv=172&tsv=201&wNotes=on">MMP2↓</a>,
<a href="tbResList.php?qv=172&tsv=203&wNotes=on">MMP9↓</a>,
<a href="tbResList.php?qv=172&tsv=308&wNotes=on">TIMP2</a>,
<a href="tbResList.php?qv=172&tsv=415&wNotes=on">IGF-1↓</a>,
<a href="tbResList.php?qv=172&tsv=428&wNotes=on">uPA↓</a>, -->
<a href="tbResList.php?qv=172&tsv=334&wNotes=on">VEGF↓</a>(mostly regulated up in normal cells),
<!-- <a href="tbResList.php?qv=172&tsv=1284&wNotes=on">ROCK1↓</a>,
<a href="tbResList.php?qv=172&tsv=110&wNotes=on">FAK↓</a>,
<a href="tbResList.php?qv=172&tsv=273&wNotes=on">RhoA↓</a>,
<a href="tbResList.php?qv=172&tsv=214&wNotes=on">NF-κB↓</a>,
<a href="tbResList.php?qv=172&tsv=79&wNotes=on">CXCR4↓</a>,
<a href="tbResList.php?qv=172&tsv=1247&wNotes=on">SDF1↓</a>,
<a href="tbResList.php?qv=172&tsv=304&wNotes=on">TGF-β↓</a>,
<a href="tbResList.php?qv=172&tsv=719&wNotes=on">α-SMA↓</a>,
<a href="tbResList.php?qv=172&tsv=105&wNotes=on">ERK↓</a>
<a href="tbResList.php?qv=172&tsv=1178&wNotes=on">MARK4↓</a> --> <!-- contributing to tumor growth, invasion, and metastasis-->
<br>

<!-- REACTIVATE GENES : HDAC↓, DNMT1↓, DNMT3A↓, EZH2↓, P53↑, -->
<!--
- reactivate genes thereby inhibiting cancer cell growth :
<a href="tbResList.php?qv=172&tsv=140&wNotes=on">HDAC↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=DNMT">DNMTs↓</a>,
<a href="tbResList.php?qv=172&tsv=108&wNotes=on">EZH2↓</a>,
<a href="tbResList.php?qv=172&tsv=236&wNotes=on">P53↑</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=HSP">HSP↓</a>,
<a href="tbResList.php?qv=172&tsv=506&wNotes=on">Sp proteins↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=TET">TET↑</a>
<br> -->

<!-- CELL CYCLE ARREST : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓ -->
- cause Cell cycle arrest :
<a href="tbResList.php?qv=172&tsv=322&wNotes=on">TumCCA↑</a>,
<!--
<a href="tbResList.php?qv=172&tsv=73&wNotes=on">cyclin D1↓</a>,
<a href="tbResList.php?qv=172&tsv=378&wNotes=on">cyclin E↓</a>,
<a href="tbResList.php?qv=172&tsv=467&wNotes=on">CDK2↓</a>,
<a href="tbResList.php?qv=172&tsv=894&wNotes=on">CDK4↓</a>,
<a href="tbResList.php?qv=172&tsv=895&wNotes=on">CDK6↓</a>, -->
<br>

<!-- MIGRATION/INVASION : TumCMig↓, TumCI↓, FAK↓, ERK↓, -->
- inhibits Migration/Invasion :
<a href="tbResList.php?qv=172&tsv=326&wNotes=on">TumCMig↓</a>,
<a href="tbResList.php?qv=172&tsv=324&wNotes=on">TumCI↓</a>,
<a href="tbResList.php?qv=172&tsv=309&wNotes=on&word=TNF-α↓">TNF-α↓</a>, <!-- encourages invasion, proliferation, EMT, and angiogenesis -->
<!-- <a href="tbResList.php?qv=172&tsv=110&wNotes=on">FAK↓</a>,
<a href="tbResList.php?qv=172&tsv=105&wNotes=on">ERK↓</a>,
<a href="tbResList.php?qv=172&tsv=96&wNotes=on">EMT↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=TOP">TOP1↓</a>,
<a href="tbResList.php?qv=172&tsv=657&wNotes=on">TET1</a>, -->
<br>

<!-- GLYCOLYSIS : ATP↓, HIF-1α↓, PKM2↓, cMyc↓, PDK1↓, GLUT1↓, LDHA↓, HK2↓, Glucose↓, GlucoseCon↓, lactateProd, OXPHOS -->
- inhibits
<a href="tbResList.php?qv=172&tsv=129&wNotes=on">glycolysis</a>
/<a href="tbResList.php?qv=172&tsv=947&wNotes=on">Warburg Effect</a> and
<a href="tbResList.php?qv=172&tsv=21&wNotes=on&word=ATP↓">ATP depletion</a> :
<a href="tbResList.php?qv=172&tsv=143&wNotes=on">HIF-1α↓</a>,
<a href="tbResList.php?qv=172&tsv=772&wNotes=on">PKM2↓</a>,
<!-- <a href="tbResList.php?qv=172&tsv=35&wNotes=on">cMyc↓</a>, -->
<a href="tbResList.php?qv=172&tsv=566&wNotes=on&word=GLUT">GLUT1↓</a>,
<a href="tbResList.php?qv=172&tsv=906&wNotes=on">LDH↓</a>,
<!-- <a href="tbResList.php?qv=172&tsv=175&wNotes=on&word=LDH">LDHA↓</a>, -->
<a href="tbResList.php?qv=172&tsv=773&wNotes=on">HK2↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=PFK">PFKs↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=PDK">PDKs↓</a>,
<a href="tbResList.php?qv=172&tsv=847&wNotes=on">ECAR↓</a>,
<a href="tbResList.php?qv=172&tsv=230&wNotes=on">OXPHOS↓</a>,
<a href="tbResList.php?qv=172&tsv=356&wNotes=on">GRP78↑</a>,
<a href="tbResList.php?qv=172&tsv=1278&wNotes=on">Glucose↓</a>,
<a href="tbResList.php?qv=172&tsv=623&wNotes=on">GlucoseCon↓</a>
<br>


<!-- ANGIOGENESIS : VEGF↓, VEGFR2↓, HIF-1α↓, NOTCH↓, FGF↓, PDGF↓, EGFR↓ ITG(Integrins↓)-->
- inhibits
<a href="tbResList.php?qv=172&tsv=447&wNotes=on">angiogenesis↓</a> :
<a href="tbResList.php?qv=172&tsv=334&wNotes=on">VEGF↓</a>,
<a href="tbResList.php?qv=172&tsv=143&wNotes=on">HIF-1α↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=NOTCH">Notch↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=FGF">FGF↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=PDGF">PDGF↓</a>,
<a href="tbResList.php?qv=172&tsv=94&wNotes=on&word=EGFR↓">EGFR↓</a>,
<a href="tbResList.php?qv=172&&wNotes=on&word=ITG">Integrins↓</a>,
<br>

<!-- CSCs : CSC↓, CK2↓, Hh↓, GLi↓, GLi1↓, -->
<!--
- inhibits Cancer Stem Cells :
<a href="tbResList.php?qv=172&tsv=795&wNotes=on">CSC↓</a>,
<a href="tbResList.php?qv=172&tsv=524&wNotes=on">CK2↓</a>,
<a href="tbResList.php?qv=172&tsv=141&wNotes=on">Hh↓</a>,
<a href="tbResList.php?qv=172&tsv=434&wNotes=on">GLi↓</a>,
<a href="tbResList.php?qv=172&tsv=124&wNotes=on">GLi1↓</a>,
<a href="tbResList.php?qv=172&tsv=677&wNotes=on">CD133↓</a>,
<a href="tbResList.php?qv=172&tsv=655&wNotes=on">CD24↓</a>,
<a href="tbResList.php?qv=172&tsv=342&wNotes=on">β-catenin↓</a>,
<a href="tbResList.php?qv=172&tsv=357&wNotes=on">n-myc↓</a>,
<a href="tbResList.php?qv=172&tsv=656&wNotes=on">sox2↓</a>,
<a href="tbResList.php?qv=172&wNotes=on&word=NOTCH">Notch2↓</a>,
<a href="tbResList.php?qv=172&tsv=1024&wNotes=on">nestin↓</a>,
<a href="tbResList.php?qv=172&tsv=508&wNotes=on">OCT4↓</a>,
<br> -->

<!-- OTHERS : -->
- Others: <a href="tbResList.php?qv=172&tsv=252&wNotes=on">PI3K↓</a>,
<a href="tbResList.php?qv=172&tsv=4&wNotes=on">AKT↓</a>,
<!-- <a href="tbResList.php?qv=172&wNotes=on&word=JAK">JAK↓</a>, -->
<a href="tbResList.php?qv=172&wNotes=on&word=STAT">STAT↓</a>,
<a href="tbResList.php?qv=172&tsv=377&wNotes=on">Wnt↓</a>,
<a href="tbResList.php?qv=172&tsv=342&wNotes=on">β-catenin↓</a>,
<!-- <a href="tbResList.php?qv=172&tsv=9&wNotes=on">AMPK</a>, -->
<!-- <a href="tbResList.php?qv=172&tsv=475&wNotes=on">α↓</a>, -->
<a href="tbResList.php?qv=172&tsv=105&wNotes=on">ERK↓</a>,
<!-- <a href="tbResList.php?qv=172&tsv=1014&wNotes=on">5↓</a>, -->
<a href="tbResList.php?qv=172&tsv=168&wNotes=on">JNK</a>,


- <a href="tbResList.php?qv=172&wNotes=on&word=SREBP">SREBP</a> (related to cholesterol).<br>


<!-- SYNERGIES : -->
- Synergies:
<a href="tbResList.php?qv=172&tsv=1106&wNotes=on">chemo-sensitization</a>,
<a href="tbResList.php?qv=172&tsv=1171&wNotes=on">chemoProtective</a>,
<a href="tbResList.php?qv=172&tsv=1233&wNotes=on">cytoProtective</a>,
<a href="tbResList.php?qv=172&tsv=1107&wNotes=on">RadioSensitizer</a>,
<a href="tbResList.php?qv=172&tsv=1185&wNotes=on">RadioProtective</a>,
<a href="tbResList.php?qv=172&tsv=961&esv=2&wNotes=on&exSp=open">Others(review target notes)</a>,
<a href="tbResList.php?qv=172&tsv=1105&wNotes=on">Neuroprotective</a>,
<!-- <a href="tbResList.php?qv=172&tsv=557&wNotes=on">Cognitive</a>, -->
<!-- <a href="tbResList.php?qv=172&tsv=1175&wNotes=on">Renoprotection</a>, -->
<a href="tbResList.php?qv=172&tsv=1179&wNotes=on">Hepatoprotective</a>,
<a href="tbResList.php?&qv=172&tsv=1188&wNotes=on">CardioProtective</a>,

<br>
<br>
<!-- SELECTIVE: -->
- Selectivity:
<a href="tbResList.php?qv=172&tsv=1110&wNotes=on">Cancer Cells vs Normal Cells</a><br>
<br>



<h3>Magnetic Field Mechanisms in Cancer</h3>
<table>
<tr>
<th>Rank</th>
<th>Pathway / Axis</th>
<th>Cancer Cells</th>
<th>Normal Cells</th>
<th>TSF</th>
<th>Primary Effect</th>
<th>Notes / Interpretation</th>
</tr>
<tr>
<td>1</td>
<td>ROS and redox homeostasis</td>
<td>↑ ROS (context-dependent); ↑ oxidative stress</td>
<td>↑ transient ROS followed by ↔ or ↓ ROS in adaptive protocols</td>
<td>P, R, G</td>
<td>Redox perturbation</td>
<td>One of the most recurrent MF mechanisms. Direction is strongly field- and cell-dependent; sustained ROS elevation is reported in several cancer models and during chemotherapy sensitization.</td>
</tr>
<tr>
<td>2</td>
<td>Ca²⁺ and ion-channel signaling</td>
<td>↑ Ca²⁺ signaling or dysregulation; altered TRPC and voltage-sensitive channel activity</td>
<td>↑ transient signaling with homeostatic recovery (context-dependent)</td>
<td>P, R</td>
<td>Electrophysiological signal transduction</td>
<td>Ca²⁺ is a major mechanistic bridge between membrane sensing, mitochondria, ROS, proliferation and apoptosis. Response depends strongly on waveform and frequency.</td>
</tr>
<tr>
<td>3</td>
<td>Mitochondrial function and membrane potential</td>
<td>↓ ΔΨm; altered respiration; ↑ mitochondrial stress</td>
<td>↔ or reversible modulation (context-dependent)</td>
<td>P, R, G</td>
<td>Bioenergetic destabilization</td>
<td>Mitochondrial effects can arise downstream of ROS and Ca²⁺ signaling and contribute to apoptotic commitment.</td>
</tr>
<tr>
<td>4</td>
<td>Apoptosis and caspase signaling</td>
<td>↑ apoptosis; ↑ caspases; ↑ PARP cleavage; ↑ Bax; ↓ survivin</td>
<td>↔ or substantially weaker response in selective protocols</td>
<td>R, G</td>
<td>Programmed cell death</td>
<td>Reported with several PEMF and time-varying field protocols and can be amplified when combined with chemotherapy.</td>
</tr>
<tr>
<td>5</td>
<td>EGFR PI3K AKT mTOR signaling</td>
<td>↓ EGFR/AKT/mTOR signaling (model-dependent)</td>
<td>↔ or mixed</td>
<td>R, G</td>
<td>Growth-signal suppression</td>
<td>Particularly supported in static-field experiments; response varies with cell type, cell density and field intensity.</td>
</tr>
<tr>
<td>6</td>
<td>Cell cycle and proliferation</td>
<td>↓ proliferation; ↑ cell-cycle arrest or mitotic disruption</td>
<td>↔ or mixed</td>
<td>G</td>
<td>Growth suppression</td>
<td>Effects are highly protocol-specific. Some exposures are neutral or can stimulate proliferation, so suppression should not be treated as universal.</td>
</tr>

<tr>
<td>7</td>
<td>DNA damage and DNA-damage response</td>
<td>↑ DNA damage; ↑ ATM/p53/p21 signaling (context-dependent)</td>
<td>↔ or mixed; protective responses reported with some protocols</td>
<td>R, G</td>
<td>Genotoxic stress and repair modulation</td>
<td>Often secondary to ROS and particularly evident during combination treatment with chemotherapy or radiation. Magnetic fields alone are not consistently genotoxic, and some static-field protocols can reduce radiation-associated DNA damage.</td>
</tr>

<tr>
<td>8</td>
<td>Chemosensitization and drug uptake</td>
<td>↑ chemotherapy response; ↑ drug uptake or cytotoxicity</td>
<td>↔ or ↑ toxicity (drug-dependent)</td>
<td>R, G</td>
<td>Adjunctive anticancer effect</td>
<td>Documented with doxorubicin, etoposide and other agents. Selectivity is not guaranteed; normal-cell toxicity must be evaluated for each field-drug combination.</td>
</tr>
<tr>
<td>9</td>
<td>Glutathione and antioxidant buffering</td>
<td>↓ GSH reserve or altered GSH/GSSG balance (context-dependent)</td>
<td>↑ GSH or antioxidant adaptation in some protocols</td>
<td>R, G</td>
<td>Redox buffering modulation</td>
<td>GSH depletion is best interpreted as a consequence of oxidative load rather than a universal direct MF target.</td>
</tr>
<tr>
<td>10</td>
<td>NRF2 antioxidant response</td>
<td>↔ / mixed; inadequate adaptive response in some oxidative protocols</td>
<td>↑ NRF2 and antioxidant-response signaling in some protective protocols</td>
<td>R, G</td>
<td>Adaptive antioxidant defense</td>
<td>NRF2 direction is not uniform enough to classify MF globally as either an NRF2 activator or inhibitor.</td>
</tr>
<tr>
<td>11</td>
<td>ER stress and unfolded protein response</td>
<td>↑ ER stress and UPR (model-dependent)</td>
<td>↑ adaptive stress response or ↔</td>
<td>R, G</td>
<td>Proteostasis stress</td>
<td>Can develop secondary to ROS, altered Ca²⁺ handling and mitochondrial dysfunction.</td>
</tr>
<tr>
<td>12</td>
<td>Mitochondrial permeability transition</td>
<td>↑ MPTP opening propensity</td>
<td>↔ or reversible opening</td>
<td>R</td>
<td>Mitochondrial death commitment</td>
<td>Supported mechanistically for specific ELF-MF exposures through ROS-sensitive pathways; should not be generalized to all magnetic fields.</td>
</tr>
<tr>
<td>13</td>
<td>Glycolysis and cellular energetics</td>
<td>↓ glycolytic flux or altered ATP production (model-dependent)</td>
<td>↔ or metabolic adaptation</td>
<td>R, G</td>
<td>Metabolic reprogramming</td>
<td>Some frequency-tuned exposures suppress glycolysis, but this is substantially less universal than ROS or Ca²⁺ modulation.</td>
</tr>
<tr>
<td>14</td>
<td>HIF-1α and angiogenic signaling</td>
<td>↓ HIF-1α / VEGF in selected models</td>
<td>↑ VEGF or tissue-repair signaling in some regenerative protocols</td>
<td>G</td>
<td>Angiogenesis modulation</td>
<td>Potential cancer-versus-normal-tissue divergence is attractive but remains highly exposure- and model-specific.</td>
</tr>
<tr>
<td>15</td>
<td>NF-κB and inflammatory signaling</td>
<td>↓ NF-κB and inflammatory signaling in selected models</td>
<td>↓ inflammatory cytokines in many regenerative PEMF applications</td>
<td>R, G</td>
<td>Inflammation modulation</td>
<td>Better established as an anti-inflammatory/regenerative PEMF effect than as a universal cancer-cell mechanism.</td>
</tr>
<tr>
<td>16</td>
<td>Migration invasion and angiogenesis</td>
<td>↓ migration; ↓ invasion; ↓ angiogenic signaling in selected models</td>
<td>↔ or pro-repair angiogenesis (context-dependent)</td>
<td>G</td>
<td>Metastatic phenotype modulation</td>
<td>Direction varies substantially with field protocol and normal-versus-tumor context.</td>
</tr>
<tr>
<td>17</td>
<td>Radiosensitization</td>
<td>↑ radiation-induced ROS and DNA damage in selected protocols</td>
<td>Mixed; radioprotection has also been reported with other protocols</td>
<td>R, G</td>
<td>Modification of radiation response</td>
<td>Both radiosensitizing and radioprotective responses have been reported; field parameters and tissue context determine direction.</td>
</tr>
<tr>
<td>18</td>
<td>Clinical Translation Constraint</td>
<td>Field-specific response; substantial tumor heterogeneity</td>
<td>Potential tissue-specific physiological effects</td>
<td>G</td>
<td>Translation limitation</td>
<td>No pharmacokinetic dose metric exists. Field strength, frequency, waveform, geometry, gradients, duration and induced electric fields must be specified. Most anticancer evidence remains preclinical and protocols are poorly standardized.</td>
</tr>
</table>
<p>P: 0–30 min &nbsp;&nbsp;&nbsp; R: 30 min–3 hr &nbsp;&nbsp;&nbsp; G: &gt;3 hr</p>


MPTP: opening represents a mitochondrial commitment event integrating ROS and Ca²⁺ stress; sustained opening indicates irreversible bioenergetic failure.<br>




<br><br>
<hr>
<br><br>


<p><b>Alzheimer’s disease relevance:</b> Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive magnetic neuromodulation modality with randomized human evidence for modest improvement in global cognition in mild cognitive impairment and Alzheimer’s disease. The strongest recent evidence supports excitatory stimulation of cortical cognitive-network regions, particularly the dorsolateral prefrontal cortex. The mechanism is principally neural-network and synaptic modulation rather than the systemic ROS-based mechanism often discussed for low-intensity PEMF. Meta-analyses generally report cognitive benefit, but protocol heterogeneity, small trials and uncertain durability remain important limitations. rTMS should therefore be classified as investigational or adjunctive for AD rather than an established disease-modifying treatment.</p>

<p><b>Clinical evidence status:</b> Multiple RCTs and meta-analyses support a modest short-term cognitive signal. Longer-term benefit remains less certain, optimal frequency/intensity/site protocols are not standardized, and evidence does not establish prevention or reversal of Alzheimer pathology.</p>


<h3>Magnetic Stimulation in Alzheimer’s Disease</h3>
<table>
<tr>
<th>Rank</th>
<th>Pathway / Axis</th>
<th>Modulation</th>
<th>TSF</th>
<th>Primary Effect</th>
<th>Notes / Interpretation</th>
</tr>
<tr>
<td>1</td>
<td>Cortical network excitability</td>
<td>↑</td>
<td>P, R</td>
<td>Neuromodulation</td>
<td>High-frequency rTMS and excitatory stimulation of cortical network hubs can increase cortical responsiveness.</td>
</tr>
<tr>
<td>2</td>
<td>Synaptic plasticity</td>
<td>↑</td>
<td>R, G</td>
<td>Plasticity enhancement</td>
<td>Repeated stimulation can produce LTP-like network effects and is a leading explanation for persistence beyond the stimulation session.</td>
</tr>
<tr>
<td>3</td>
<td>Cognitive-network connectivity</td>
<td>↑</td>
<td>G</td>
<td>Network normalization</td>
<td>DLPFC and related cortical networks are the most consistently studied targets.</td>
</tr>
<tr>
<td>4</td>
<td>Global cognition</td>
<td>↑</td>
<td>G</td>
<td>Clinical cognitive improvement</td>
<td>Recent meta-analyses show modest improvement in MMSE, MoCA or ADAS-Cog outcomes, although heterogeneity remains substantial.</td>
</tr>
<tr>
<td>5</td>
<td>Neuroinflammation and neurotrophic signaling</td>
<td>↓ inflammation; ↑ neurotrophic signaling (context-dependent)</td>
<td>G</td>
<td>Secondary neurobiological effects</td>
<td>Supported mainly by mechanistic and preclinical studies; less directly established than cortical-network effects in human AD.</td>
</tr>
<tr>
<td>6</td>
<td>Clinical Translation Constraint</td>
<td>↔</td>
<td>G</td>
<td>Protocol heterogeneity</td>
<td>Optimal stimulation site, frequency, intensity, pulse count, session number and maintenance schedule remain unresolved; long-term disease modification has not been demonstrated.</td>
</tr>
</table>
<p>P: 0–30 min &nbsp;&nbsp;&nbsp; R: 30 min–3 hr &nbsp;&nbsp;&nbsp; G: &gt;3 hr</p>


Pathway results for Effect on Cancer / Diseased Cells

NA, unassigned(tgid=0) ⓘ

compII↓, 1,   K+↑, 1,   NA↑, 1,   PV↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ATF3↑, 1,   Catalase↑, 4,   Catalase↓, 1,   Fenton↑, 1,   Ferroptosis↑, 2,   GPx↓, 1,   GPx1↑, 1,   GPx1↓, 1,   GPx4↓, 1,   GSH↓, 2,   GSH↑, 1,   GSH/GSSG↓, 2,   GSR↑, 1,   mt-H2O2↑, 1,   H2O2↑, 7,   i-Iron↓, 1,   Iron↑, 2,   Iron↓, 1,   lipid-P↑, 2,   MDA↑, 2,   OXPHOS↑, 3,   PARK2↑, 1,   Prx6↑, 1,   ROS↑, 8,   ROS↝, 3,   ROS⇅, 1,   ROS↓, 2,   mt-ROS↑, 2,   RPM↑, 2,   RPM↓, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 1,   SOD1↑, 1,   SOD1↓, 1,   SOD2↑, 2,   SOD2↓, 1,   Thiols↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 2,   ATP↑, 1,   ATP⇅, 1,   ATP↓, 2,   ATP∅, 1,   ETC↓, 5,   mitResp↓, 1,   mitResp↑, 1,   MMP?, 1,   MMP↓, 10,   MMP↑, 1,   MPT↑, 2,   mtDam↑, 3,   OCR↓, 1,   OCR↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   PleEff↓, 1,   SDH↓, 2,   UCP1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACAA1↓, 1,   ALAT↓, 2,   BCAP↓, 1,   cAMP⇅, 1,   cMyc↓, 2,   DHCR24↑, 1,   ECAR↓, 1,   FABP4↓, 1,   GlucoseCon↓, 1,   Glycolysis∅, 1,   Glycolysis↓, 3,   lactateProd↑, 1,   PCK1↓, 1,   PKM2↓, 1,   PLIN1↓, 1,   PPARγ↑, 1,   Pyruv↓, 2,   SIRT1↑, 1,   TCA?, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 5,   p‑BAD↓, 1,   Bak↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↝, 1,   Casp↑, 1,   Casp3↑, 2,   Casp3↓, 1,   cl‑Casp3↑, 2,   Casp7↑, 3,   Casp7↓, 1,   cl‑Casp7↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   Chk2↑, 2,   Cyt‑c↑, 3,   Cyt‑c↝, 1,   Endon↑, 1,   Fas↑, 1,   Ferroptosis↑, 2,   iNOS↑, 1,   JNK↑, 1,   lysoMP↑, 3,   lysoMP↓, 2,   MAPK↑, 3,   MAPK↓, 1,   Mcl-1↓, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p38↑, 2,   survivin↓, 3,   Telomerase↓, 2,   TRPV1↑, 1,   TRPV1↝, 1,   TumCD↑, 11,   TumCD∅, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   p‑Akt↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 2,   ChrMod↑, 2,   p‑H3↓, 1,   miR-129-5p↑, 1,   miR-21↑, 1,   other↑, 1,   other↓, 1,   other∅, 1,   other↝, 3,   tumCV↓, 8,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 3,   ER Stress↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↓, 1,   HSP70/HSPA5∅, 1,   HSP90↓, 1,   HSPs∅, 1,   HSPs↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑CHK1↓, 1,   DNAdam↑, 11,   P53↑, 3,   P53↝, 1,   cl‑PARP↑, 3,   p‑γH2AX↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1?, 1,   CDK1↓, 1,   p‑CDK2↓, 1,   CycB/CCNB1↓, 2,   cycE/CCNE↓, 1,   E2Fs↓, 1,   mitA↑, 1,   P21↑, 1,   PLK1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 2,   CD44↓, 2,   CSCs↓, 2,   Diff↑, 1,   EMT↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   p‑ERK↝, 1,   GSK‐3β↑, 1,   miR-125b↓, 1,   miR-34a↑, 1,   mTOR↓, 2,   Nanog↓, 2,   PI3K↓, 2,   PTEN↓, 1,   RAS↑, 1,   SOX2↓, 2,   STAT3↑, 1,   p‑STAT3↑, 1,   TOP2↑, 1,   TumCG↓, 3,   VGCC↑, 1,   VGSC↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 3,   Ca+2↓, 2,   Ca+2↝, 3,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cartilage↑, 1,   CCDC150↓, 1,   COL4↓, 1,   CXCL12↓, 1,   F-actin↓, 1,   FOSB↑, 1,   ITGA1∅, 1,   ITGA11↓, 1,   ITGA5∅, 1,   ITGB1∅, 1,   ITGB3∅, 1,   ITGB4∅, 1,   LAMB3↑, 1,   miR-155↑, 1,   miR-200c↓, 1,   miR-486↑, 1,   MMP1↑, 1,   MMP2↓, 1,   MMP2↑, 2,   MMP2∅, 1,   MMP3↑, 1,   MMP9↓, 1,   MMP9↑, 1,   MMP9∅, 1,   MMPs↓, 1,   Na+↑, 1,   Rho↓, 1,   Slug↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   TGF-β↓, 2,   THBS2↓, 1,   TRPC1↑, 1,   TumCI↓, 7,   TumCMig↓, 9,   TumCP↓, 1,   TumCP∅, 1,   TumMeta↓, 7,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   angioG↓, 7,   ECM/TCF↓, 1,   EGFR↓, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   EPR↑, 2,   Hif1a↓, 1,   miR-126↓, 1,   miR-210↑, 1,   NO↑, 1,   nucleolin↑, 1,   VEGF↑, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 10,   Na+↑, 1,   P-gp/ABCB1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 3,   COX2/PTGS2↓, 1,   CXCc↓, 1,   CXCL9↓, 1,   DCells↑, 3,   FOXP3↓, 1,   GM-CSF↓, 1,   IFN-γ↓, 1,   IL1↑, 1,   IL10↑, 1,   IL12↑, 1,   IL17↓, 2,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   IL6↓, 2,   IL6↑, 1,   IL9↓, 1,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 1,   LIF↑, 1,   Macrophages↑, 1,   NF-kB↑, 1,   NF-kB↓, 1,   PD-L1↑, 1,   RANTES↓, 1,   T-Cell↑, 1,   TNF-α↓, 1,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↑, 1,   pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 17,   ChemoSen∅, 1,   Dose↝, 21,   Dose∅, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   eff↓, 14,   eff↑, 31,   eff↝, 15,   eff⇅, 1,   MDR1↓, 1,   RadioS↑, 6,   selectivity↑, 29,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 1,   BloodF↑, 1,   BMD↑, 2,   BMPs↑, 1,   Calcium↑, 1,   EGFR↓, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   Ferritin↓, 1,   IL6↓, 2,   IL6↑, 1,   PD-L1↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   Appetite↑, 2,   breath↑, 2,   chemoP↑, 2,   ChemoSideEff↓, 1,   cognitive↑, 2,   hepatoP↑, 1,   OS↑, 2,   OS⇅, 1,   Pain↓, 1,   QoL↑, 3,   radioP↑, 3,   Sleep↑, 3,   Strength↑, 4,   toxicity↓, 1,   TumVol↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↓, 1,   CD8+↑, 3,  
Total Targets: 343

Pathway results for Effect on Normal Cells

NA, unassigned(tgid=0) ⓘ

PV↓, 3,   UFR↑, 2,   UR↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 8,   GPx∅, 1,   GPx↑, 4,   GPx1↑, 5,   GPx3↑, 1,   GPx4↑, 5,   GSH∅, 1,   GSH↑, 1,   GSR↑, 3,   GSSG↓, 1,   HO-1↑, 1,   Iron↑, 1,   Keap1↓, 1,   MDA↓, 5,   MDA↑, 1,   NRF2↑, 3,   OXPHOS↓, 2,   OXPHOS↑, 2,   ROMO1↑, 1,   ROS∅, 1,   ROS↓, 28,   ROS↑, 8,   ROS↝, 1,   ROS⇅, 2,   mt-ROS↑, 2,   RPM↑, 1,   SOD↑, 9,   SOD1↑, 5,   SOD2↓, 1,   SOD2↑, 5,   TAC↑, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   ATP↑, 3,   ETC↓, 2,   Insulin↓, 1,   mitResp↓, 1,   MMP∅, 1,   MMP↝, 1,   MMP↑, 3,   MMP⇅, 1,   MPT↑, 1,   mt-OCR↑, 1,   OCR↑, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   cAMP↑, 2,   p‑CREB↑, 1,   ECAR↓, 1,   ECAR↑, 1,   FABP4↓, 1,   FAO↑, 1,   FAO↓, 1,   Glycolysis↑, 2,   Glycolysis↓, 1,   HK2↑, 2,   lactateProd↓, 1,   LDH↓, 1,   LDHB↑, 1,   NAD↑, 1,   PFKL↑, 2,   PFKM↑, 2,   PFKP↑, 1,   PKM2↑, 2,   PONs↓, 1,   PPARγ↓, 1,   PPP↓, 1,   SREBP1/SREBF1↓, 1,   TCA↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   BAD↓, 1,   BAX↓, 3,   Bcl-2∅, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   BMP2↑, 2,   proCasp1↓, 1,   cl‑Casp1↓, 1,   Casp1↓, 1,   Casp3↓, 2,   Cyt‑c↑, 2,   GSDMD↓, 1,   GSDMD?, 1,   HEY1↑, 1,   HGF/c-Met↑, 1,   iNOS↓, 3,   iNOS↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 3,   MAPK↓, 1,   MAPK↑, 2,   necrosis↓, 1,   p38↑, 2,   p‑p38↓, 1,   RKIP↑, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↑, 1,   p‑Akt↓, 1,   Akt↑, 2,   Akt↓, 2,   OCN∅, 1,   OCN↑, 1,   SOX9↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↑, 15,   other↝, 10,   other?, 3,   other↓, 2,   TREM-1↓, 1,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↑, 5,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↑, 1,   cFos↑, 1,   Diff↓, 1,   Diff↑, 9,   Diff↝, 1,   p‑ERK↑, 2,   p‑ERK↓, 1,   ERK↓, 1,   ERK↑, 2,   FGF↑, 5,   p‑GSK‐3β↑, 1,   GSK‐3β↓, 1,   IGF-1↑, 1,   MSCs↑, 1,   mTOR↓, 4,   mTOR↑, 2,   mTOR↝, 1,   NOTCH↑, 1,   NOTCH1↑, 1,   p‑P70S6K↑, 1,   PI3K↑, 1,   PI3K↓, 1,   PTEN↑, 1,   RUNX2∅, 1,   RUNX2↑, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG∅, 1,   TumCG↑, 1,   VGCC↑, 1,   Wnt↑, 3,  

Migration(tgid=13) ⓘ

APP∅, 1,   ARG1/2↑, 1,   Ca+2↓, 6,   Ca+2↝, 2,   Ca+2∅, 1,   Ca+2↑, 11,   i-Ca+2↓, 1,   Cartilage↑, 2,   CDK5↓, 1,   COL1∅, 1,   COL2A1↑, 2,   F-actin↑, 1,   FAK↑, 2,   ITGB1↑, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↑, 2,   MMP9↓, 3,   MMP9↑, 2,   MMPs↑, 1,   Netrins↑, 1,   OPN↑, 1,   PDGF↑, 1,   PKA↑, 1,   PKCδ↓, 1,   SMAD4↑, 1,   SMAD5↑, 1,   STAC2↑, 1,   TGF-β↑, 4,   TGF-β1↑, 1,   TIMP1↑, 2,   TIMP2↑, 1,   Treg lymp↓, 1,   TRPC1↑, 1,   TumCMig↑, 1,   β-catenin/ZEB1↑, 4,   β-Endo↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 7,   angioG↝, 1,   EGR4↑, 1,   HIF-1↓, 1,   Hif1a∅, 2,   Hif1a↑, 2,   Hif1a↝, 1,   HIF2a↑, 1,   miR-34b-5p↓, 1,   NO↓, 4,   NO↑, 5,   NPY↑, 1,   PDGFR-BB↑, 1,   VEGF↑, 11,   VEGF↓, 1,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   GLUT1↑, 2,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 2,   CXCc↓, 1,   GM-CSF↑, 1,   IFN-γ↓, 1,   p‑IKKα↓, 2,   IL1↓, 2,   IL1↑, 1,   IL10↑, 5,   IL17↓, 1,   IL1β↓, 6,   IL1β↑, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 6,   IL6↑, 1,   IL8↓, 2,   Inflam↓, 30,   Inflam∅, 1,   IP-10/CXCL-10↑, 1,   p‑IκB↓, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↑, 2,   MIP‑1α/CCL3↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 6,   p‑p65↓, 1,   PGE2↓, 3,   PGE2↑, 1,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 2,   AChE↓, 1,   BDNF↑, 11,   NGF↑, 1,   PSD95↑, 1,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 9,   Aβ?, 1,   Aβ∅, 2,   BACE/β-secretase↓, 1,   NLRP3↓, 2,   β-Amyloid↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 4,   Dose↝, 33,   Dose∅, 1,   eff↝, 5,   eff↓, 6,   eff↑, 21,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALP∅, 1,   ALP↑, 2,   BloodF↑, 4,   BMD↑, 12,   BMPs↓, 1,   BMPs↑, 1,   GutMicro↑, 1,   IL6↓, 6,   IL6↑, 1,   LDH↓, 1,   NSE↑, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   cardioP↑, 3,   chemoP↑, 1,   cognitive↑, 21,   cognitive∅, 1,   cytoP↑, 1,   hepatoP↑, 1,   memory↑, 19,   memory∅, 2,   Mood⇅, 1,   motorD↑, 10,   neuroP↑, 19,   OS↑, 2,   Pain↓, 8,   QoL↑, 5,   Strength↑, 1,   toxicity∅, 9,   toxicity↓, 6,   toxicity?, 1,   Weight∅, 1,  
Total Targets: 297

Research papers

Year Title Authors PMID Link Flag
2024Polyvinyl Alcohol Capped Silver Nanostructures for Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field Hany G AttiaPMC11401528https://pmc.ncbi.nlm.nih.gov/articles/PMC11401528/0
2022Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro studyAly Fahmy MohamedPMC8817517 https://pmc.ncbi.nlm.nih.gov/articles/PMC8817517/0
2022Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro studyAly Fahmy MohamedPMC8817517https://pmc.ncbi.nlm.nih.gov/articles/PMC8817517/0
2022The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)Agnieszka Synowiec‑Wojtarowicz—https://www.researchgate.net/publication/357987947_The_effect_of_a_static_magnetic_field_and_baicalin_or_baicalein_interactions_on_amelanotic_melanoma_cell_cultures_C320
2019Capsaicin: Effects on the Pathogenesis of Hepatocellular CarcinomaCristian ScheauPMC6651067https://pmc.ncbi.nlm.nih.gov/articles/PMC6651067/0
2022Characterization of mesenchymal stem cells with augmented internalization of magnetic nanoparticles: The implication of therapeutic potentialChing-Hui Chien—https://www.sciencedirect.com/science/article/abs/pii/S03048853220094530
2022Laminin Receptor-Mediated Nanoparticle Uptake by Tumor Cells: Interplay of Epigallocatechin Gallate and Magnetic Force at Nano-Bio InterfaceSheng-Chieh HsuPMC9330565https://pmc.ncbi.nlm.nih.gov/articles/PMC9330565/0
2018Interaction of poly-l-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cellsWei Xiong Siow—https://www.researchgate.net/publication/323871065_Interaction_of_poly-l-lysine_coating_and_heparan_sulfate_proteoglycan_on_magnetic_nanoparticle_uptake_by_tumor_cells0
2014Augmented cellular uptake of nanoparticles using tea catechins: effect of surface modification on nanoparticle-cell interactionYi-Ching Lu25069428https://pubmed.ncbi.nlm.nih.gov/25069428/0
2019In vitro evaluation of electroporated gold nanoparticles and extremely-low frequency electromagnetic field anticancer activity against Hep-2 laryngeal cancer cellsMohammed A. Alshehri 31746453https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/641080
2026Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysicsPrerna VermaPMC13055096https://pmc.ncbi.nlm.nih.gov/articles/PMC13055096/0
2026Efficacy and Durability of Repetitive Transcranial Magnetic Stimulation on Cognitive Function in Patients With Mild-to-Moderate Alzheimer's Disease: A Systematic Review and Meta-AnalysisQian ZhouPMC13549796https://pmc.ncbi.nlm.nih.gov/articles/PMC13549796/0
2026Pulsed electromagnetic fields induce ferroptosis in osteosarcoma cells and promote osteogenic differentiationYingang LiPMC13579143https://pmc.ncbi.nlm.nih.gov/articles/PMC13579143/0
2026Pulsed Electromagnetic Field Increases Doxorubicin-induced Mitotic Slippage in MDA-MB-231 Breast Cancer CellsSung-Hun Woo42373288https://pubmed.ncbi.nlm.nih.gov/42373288/0
2026Magnetic Fields in Cancer Therapy: Mechanistic Insights, Signaling Pathways, and Evidence from Clinical and In Vitro StudiesSadettin Berkay SarliPMC13306740https://pmc.ncbi.nlm.nih.gov/articles/PMC13306740/0
2025Unveiling the Power of Magnetic-Driven Regenerative Medicine: Bone Regeneration and Functional ReconstructionChenxi XuPMC12095915https://pmc.ncbi.nlm.nih.gov/articles/PMC12095915/0
2025Early intervention using long-term rhythmic pulsed magnetic stimulation alleviates cognitive decline in a 5xFAD mouse model of Alzheimer's diseaseXue Wang—https://www.sciencedirect.com/science/article/abs/pii/S00144886240032850
2025Extremely Low‐Frequency and Low‐Intensity Electromagnetic Field Technology (ELF‐EMF) Sculpts MicrotubulesAlexandra LobyntsevaPMC11835790https://pmc.ncbi.nlm.nih.gov/articles/PMC11835790/0
2025Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancerMargit Egg—https://www.sciencedirect.com/science/article/pii/S22132317240046100
2025PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting NeurodegenerationStefania Merighi—https://www.mdpi.com/1422-0067/26/13/64950
2025Examining the effects of extremely low-frequency magnetic fields on cognitive functions and functional brain markers in aged miceSenka HadzibegovicPMC11897315https://pmc.ncbi.nlm.nih.gov/articles/PMC11897315/0
2025Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model studyFeng Liao—https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-025-04792-30
2025Confronting stem cells with surface-modified magnetic nanoparticles and low-frequency pulsed electromagnetic fieldBurcu Bayramli-Öne—https://link.springer.com/article/10.1007/s42247-025-00997-x0
2025One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot StudyJan Nikolas IversenPMC11899448https://pmc.ncbi.nlm.nih.gov/articles/PMC11899448/0
2025Static magnetic field promotes the doxorubicin toxicity effects on osteosarcoma cellsFatemeh RajabiPMC11977194https://pmc.ncbi.nlm.nih.gov/articles/PMC11977194/0
2025The effect of repetitive transcranial magnetic stimulation on immediate and long-term cognitive functions in Alzheimer's dementia and mild cognitive impairment: a meta-analysisBojun WangPMC12707008https://pmc.ncbi.nlm.nih.gov/articles/PMC12707008/0
2025Therapeutic potential and mechanisms of repetitive transcranial magnetic stimulation in Alzheimer’s disease: a literature reviewXinlei ZhangPMC11969782https://pmc.ncbi.nlm.nih.gov/articles/PMC11969782/0
2024Comparison of pulsed and continuous electromagnetic field generated by WPT system on human dermal and neural cellsRomana ZahumenskaPMC10918061https://pmc.ncbi.nlm.nih.gov/articles/PMC10918061/0
2024Positive and Negative Effects of Administering a Magnetic Field to Patients with Rheumatoid Arthritis (RA)Jolanta ZwolińskaPMC10971695https://pmc.ncbi.nlm.nih.gov/articles/PMC10971695/0
2024Current Evidence Using Pulsed Electromagnetic Fields in Osteoarthritis: A Systematic ReviewLuigi Cianni—https://www.mdpi.com/2077-0383/13/7/19590
2024Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigmMark M FusterPMC11333800https://pmc.ncbi.nlm.nih.gov/articles/PMC11333800/0
2024Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesisChengyi YangPMC11329790https://pmc.ncbi.nlm.nih.gov/articles/PMC11329790/0
2024Brief Magnetic Field Exposure Stimulates Doxorubicin Uptake into Breast Cancer Cells in Association with TRPC1 Expression: A Precision Oncology Methodology to Enhance Chemotherapeutic OutcomeViresh Krishnan Sukumar—https://www.mdpi.com/2072-6694/16/22/38600
2024Low-frequency magnetic field therapy for glioblastoma: Current advances, mechanisms, challenges and future perspectivesYinlong Liu—https://www.sciencedirect.com/science/article/pii/S2090123224001255?via%3Dihub0
2024Electromagnetic Fields Trigger Cell Death in Glioblastoma Cells through Increasing miR-126-5p and Intracellular Ca2+ LevelsEbru Temiz39048853https://pubmed.ncbi.nlm.nih.gov/39048853/0
2024Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2Xuan Fang—https://www.nature.com/articles/s42003-024-06866-30
2024Pulsed electromagnetic fields inhibit IL-37 to alleviate CD8+ T cell dysfunction and suppress cervical cancer progressionLauren Feger—https://pemfprofessionals.com/research/pulsed-electromagnetic-fields-inhibit-il-37-to-alleviate-cd8-t-cell-dysfunction-and-suppress-cervical-cancer-progression/0
2024The effects of pulsed electromagnetic field therapy on muscle strength and pain in patients with end-stage knee osteoarthritis: a randomized controlled trialQian-wen WangPMC11521844https://pmc.ncbi.nlm.nih.gov/articles/PMC11521844/0
2024Meta-analysis of the effectiveness and safety of magnetic stimulation for chronic pelvic painHuixiang LiPMC11384379https://pmc.ncbi.nlm.nih.gov/articles/PMC11384379/0
2024The Effect of Pulsed Electromagnetic Field Stimulation of Live Cells on Intracellular Ca2+ Dynamics Changes Notably Involving Ion Channels—https://juniperpublishers.com/apbij/pdf/APBIJ.MS.ID.555710.pdf0
2024Low Magnetic Field Exposure Alters Prostate Cancer Cell PropertiesSigrun Lange—https://www.mdpi.com/2079-7737/13/9/7340
2024Pulsed Electromagnetic Fields (PEMFs) Trigger Cell Death and Senescence in Cancer CellsPavlos PantelisPMC10931548https://pmc.ncbi.nlm.nih.gov/articles/PMC10931548/0
2024Cellular and Molecular Effects of Magnetic FieldsMaciej TotaPMC11354277https://pmc.ncbi.nlm.nih.gov/articles/PMC11354277/0
2024Neurobiological effects and mechanisms of magnetic fields: a review from 2000 to 2023Xuejia WangPMC11545338https://pmc.ncbi.nlm.nih.gov/articles/PMC11545338/0
2024Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer CellsSung-Hun WOO—https://www.kjcls.org/journal/view.html?doi=10.15324%2Fkjcls.2024.56.1.730
2024Cognitive Decline: Current Intervention Strategies and Integrative Therapeutic Approaches for Alzheimer's DiseaseKate S BraniganPMC11048559https://pmc.ncbi.nlm.nih.gov/articles/PMC11048559/0
2024Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome AnalysisEnrica TorrettaPMC11354614https://pmc.ncbi.nlm.nih.gov/articles/PMC11354614/0
2024Alternative magnetic field exposure suppresses tumor growth via metabolic reprogrammingTaisuke Akimoto—https://onlinelibrary.wiley.com/doi/full/10.1111/cas.162430
2023Cytoprotective effects of low-frequency pulsed electromagnetic field against oxidative stress in glioblastoma cellsÇiğdem Gökçek-Saraç36705309https://pubmed.ncbi.nlm.nih.gov/36705309/0
2023Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterizationRaffaella Lazzarini36805133https://www.sciencedirect.com/science/article/pii/S0147651323001549?via%3Dihub0
2023Synergistic cytotoxic effects of an extremely low-frequency electromagnetic field with doxorubicin on MCF-7 cell lineShahin Ramazi—https://www.nature.com/articles/s41598-023-35767-4#Sec140
2023Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanismJie Sun—https://www.nature.com/articles/s41598-023-34144-50
2023Pulsed electromagnetic field attenuates bone fragility in estrogen-deficient osteoporosis in ratsTamara Popović36641696https://pubmed.ncbi.nlm.nih.gov/36641696/0
2023Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosisTian MaPMC10190032https://pmc.ncbi.nlm.nih.gov/articles/PMC10190032/0
2023Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma TreatmentJonas FlatscherPMC10379303https://pmc.ncbi.nlm.nih.gov/articles/PMC10379303/0
2023Induction of apoptosis in B16-BL6 melanoma cells following exposure to electromagnetic fields modeled after intercellular calcium wavesBenjamin D. Rain—https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.137600
2023An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healingJohn Helmy—https://journals.cambridgemedia.com.au/wpr/volume-32-number-2/integrative-review-pulsed-electromagnetic-field-therapy-pemf-and-wound-healing0
2023The effect of magnetic fields on tumor occurrence and progression: Recent advancesGe Zhang—https://www.sciencedirect.com/science/article/abs/pii/S00796107230002990
2023Cognitive improvement via a modulated rhythmic pulsed magnetic field in D-galactose-induced accelerated aging micePingping Wang37094765https://pubmed.ncbi.nlm.nih.gov/37094765/0
2023EMAGINE-Study protocol of a randomized controlled trial for determining the efficacy of a frequency tuned electromagnetic field treatment in facilitating recovery within the subacute phase following ischemic strokeJeffrey L SaverPMC10196621https://pmc.ncbi.nlm.nih.gov/articles/PMC10196621/0
2023Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative StressSilvia MaiullariPMC10706358https://pmc.ncbi.nlm.nih.gov/articles/PMC10706358/0
2023Extremely low-frequency electromagnetic field induces acetylation of heat shock proteins and enhances protein foldingZhizhou Huang 37717354https://www.sciencedirect.com/science/article/pii/S0147651323009867?via%3Dihub0
2023The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride IonsMagdalena Kimsa-Dudek— Magdalena Kimsa-Dudek0
2023Theta Frequency Electromagnetic Stimulation Enhances Functional Recovery After StrokeNaohiko OkabePMC11976812https://pmc.ncbi.nlm.nih.gov/articles/PMC11976812/0
2022Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damageDan Stratton35994829https://www.sciencedirect.com/science/article/pii/S0006291X22011548?via%3Dihub0
2022Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine ApproachYee Kit Tai—https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.783803/full0
2022Pulsed Electromagnetic Fields Protect Against Brain Ischemia by Modulating the Astrocytic Cholinergic Anti-inflammatory PathwayHaofuzi Zhang—https://www.researchgate.net/publication/361976845_Pulsed_Electromagnetic_Fields_Protect_Against_Brain_Ischemia_by_Modulating_the_Astrocytic_Cholinergic_Anti-inflammatory_Pathway0
2022Tumor-specific inhibition with magnetic fieldyang guanghua—https://www.researchgate.net/publication/358628498_Tumor-specific_inhibition_with_magnetic_field0
2022Magnetic field effects in biology from the perspective of the radical pair mechanismHadi Zadeh-HaghighiPMC9346374https://pmc.ncbi.nlm.nih.gov/articles/PMC9346374/0
2022Quantum based effects of therapeutic nuclear magnetic resonance persistently reduce glycolysisViktoria Thöni—https://www.sciencedirect.com/science/article/pii/S2589004222018089?pes=vor&utm_source=sciencedirect_contenthosting&getft_integrator=sciencedirect_contenthosting0
2022Pulsed electromagnetic therapy in cancer treatment: Progress and outlookWenjun Xu—https://onlinelibrary.wiley.com/doi/full/10.1002/VIW.202200290
2022Increase of intracellular Ca2+ concentration in Listeria monocytogenes under pulsed magnetic field—https://www.sciencedirect.com/science/article/abs/pii/S03048853220022190
2022Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondriaTakuro Toda—https://www.nature.com/articles/s42003-022-03389-70
2022A 50 Hz magnetic field influences the viability of breast cancer cells 96 h after exposureMaria Elexpuru-ZabaletaPMC9889515https://pmc.ncbi.nlm.nih.gov/articles/PMC9889515/0
2022The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironmentJun Zhoua—https://www.tandfonline.com/doi/full/10.1080/15368378.2024.23140930
2022Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell deathSung-Hun WooPMC8972140https://pmc.ncbi.nlm.nih.gov/articles/PMC8972140/0
2022Effects of transcranial magnetic stimulation on neurobiological changes in Alzheimer's diseaseShahid BashirPMC8845030https://pmc.ncbi.nlm.nih.gov/articles/PMC8845030/0
2022Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral IschemiaFioravante Capone MD 1—https://www.sciencedirect.com/science/article/pii/S10947159210642660
2022Frequency-tuned electromagnetic field therapy improves post-stroke motor function: A pilot randomized controlled trialBatsheva WeisingerPMC9702345https://pmc.ncbi.nlm.nih.gov/articles/PMC9702345/0
2022Chronic-Exposure Low-Frequency Magnetic Fields (Magnetotherapy and Magnetic Stimulation) Influence Serum Serotonin Concentrations in Patients with Low Back Pain-Clinical Observation StudyMarta Woldańska-OkońskaPMC9368470https://pmc.ncbi.nlm.nih.gov/articles/PMC9368470/0
2022Magnetoporation: New Method for Permeabilization of Cancerous Cells to Hydrophilic DrugsBahram YousefianPMC8995760https://pmc.ncbi.nlm.nih.gov/articles/PMC8995760/0
2022The Effect of Time-Dependence of 10 Hz Electromagnetic Field on Spatial Learning and Memory in RatsFarzaneh ZarrinPMC10082904https://pmc.ncbi.nlm.nih.gov/articles/PMC10082904/0
2022The Efficacy of Pulsed Electromagnetic Fields on Pain, Stiffness, and Physical Function in Osteoarthritis: A Systematic Review and Meta-AnalysisJie TongPMC9110240https://pmc.ncbi.nlm.nih.gov/articles/PMC9110240/0
2022In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer CellsMike Y ChenPMC9523832https://pmc.ncbi.nlm.nih.gov/articles/PMC9523832/0
2022Pulsed Electro-Magnetic Field (PEMF) Effect on Bone Healing in Animal Models: A Review of Its Efficacy Related to Different Type of DamageMattia Di BartolomeoPMC8945722https://pmc.ncbi.nlm.nih.gov/articles/PMC8945722/0
2022Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fieldsMengqian HuangPMC9939155https://pmc.ncbi.nlm.nih.gov/articles/PMC9939155/0
2022High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic fieldDan Wang—https://www.science.org/doi/10.1126/sciadv.abq02220
2022Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in miceLiyi Huang—https://www.researchgate.net/publication/362472071_Enhanced_effect_of_combining_bone_marrow_mesenchymal_stem_cells_BMMSCs_and_pulsed_electromagnetic_fields_PEMF_to_promote_recovery_after_spinal_cord_injury_in_mice0
2021Electromagnetic Field as a Treatment for Cerebral Ischemic StrokeAmanda Moya Gómez—https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.742596/full0
2021Pulsed electromagnetic fields synergize with graphene to enhance dental pulp stem cell-derived neurogenesis by selectively targeting TRPC1 channelsT T Madanagopal33644848https://pubmed.ncbi.nlm.nih.gov/33644848/0
2021Evaluation of Pulsed Electromagnetic Field Effects: A Systematic Review and Meta-Analysis on Highlights of Two Decades of Research In Vitro StudiesMahsa MansourianPMC8342182https://pmc.ncbi.nlm.nih.gov/articles/PMC8342182/0
2021Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trialAnwar Ebid—https://f1000research.com/articles/10-6490
2021Evaluation of the PTEN and circRNA-CDR1as Gene Expression Changes in Gastric Cancer and Normal Cell Lines Following the Exposure to Weak and Moderate 50 Hz Electromagnetic FieldsFereshteh Mansoury—https://brieflands.com/articles/ijcm-1110790
2021Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in OncologyAoshu XuPMC8010190https://pmc.ncbi.nlm.nih.gov/articles/PMC8010190/0
2021Magneto mitochondrial dysfunction mediated cancer cell death using intracellular magnetic nano-transducersWooram Park34075946https://pubmed.ncbi.nlm.nih.gov/34075946/0
2021Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancerMin-Haw Wang33632057https://pubmed.ncbi.nlm.nih.gov/33632057/0
2021Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosisMojdeh BaratiPMC8666288https://pmc.ncbi.nlm.nih.gov/articles/PMC8666288/0
2021Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS-Mediated Oxidative StressChao SongPMC8670934https://pmc.ncbi.nlm.nih.gov/articles/PMC8670934/0
2021Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis ratsJing Liu—https://www.ivysci.com/en/articles/6552742__Pulsed_electromagnetic_field_alleviates_synovitis_and_inhibits_the_NLRP3Caspase1GSDMD_signaling_path0
2021The Effect of Pulsed Electromagnetic Fields on AngiogenesisLihong Peng 33675261https://pubmed.ncbi.nlm.nih.gov/33675261/0
2021Anti-Oxidative and Immune Regulatory Responses of THP-1 and PBMC to Pulsed EMF Are Field-Strength DependentSilvia GroissPMC8471206https://pmc.ncbi.nlm.nih.gov/articles/PMC8471206/0
2021Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repairAlex M. Hollenberg—https://www.nature.com/articles/s41598-021-98625-10
2021Comparing the Effects of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields With Different Values on Learning, Memory, Anxiety, and β-amyloid Deposition in Adult RatsNafiseh FarajiPMC9168822https://pmc.ncbi.nlm.nih.gov/articles/PMC9168822/0
2020Pulsed Electromagnetic Fields Alleviates Hepatic Oxidative Stress and Lipids Accumulation in db/db miceYing Liu—https://www.biorxiv.org/content/10.1101/2020.04.06.028621v10
2020Reactive oxygen species (ROS) production in HepG2 cancer cell line through the application of localized alternating magnetic fieldAlberto Sola-Leyva—https://pubs.rsc.org/tb/article-abstract/8/34/7667/711718/Reactive-oxygen-species-ROS-production-in-HepG2?redirectedFrom=fulltext0
2020Changes in Ca2+ release in human red blood cells under pulsed magnetic fieldMin Hyung Seo—https://www.sciencedirect.com/science/article/abs/pii/S03048853193367040
2020Pulsed electromagnetic fields improve the healing process of Achilles tendinopathy: a pilot study in a rat modelCarlotta Perucca OrfeiPMC7533373https://pmc.ncbi.nlm.nih.gov/articles/PMC7533373/0
2020Noninvasive treatment for men suffering from enlarged prostateParsemus Foundation—https://www.parsemus.org/wp-content/uploads/2020/11/PEMF_and_BPH_press_release.pdf0
2020Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1α expression: Follow-up to an in vitro magnetic mitohormetic studyYee Kit Tai32627872https://pubmed.ncbi.nlm.nih.gov/32627872/0
2020Pulsed Electromagnetic Fields Increase Angiogenesis and Improve Cardiac Function After Myocardial Ischemia in MiceLihong Peng—https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-19-0758/_html/-char/en0
2020Magnetic fields and angiogenesisXin Zhang—https://www.researchgate.net/publication/341046662_Magnetic_fields_and_angiogenesis0
2020The role of magnetic fields in neurodegenerative diseasesJavier Riancho—https://link.springer.com/article/10.1007/s00484-020-01896-y0
2020Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disordersHongzhi Hu—https://www.sciencedirect.com/science/article/pii/S07533322203096040
2020Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemiaQiang GaoPMC8284293https://pmc.ncbi.nlm.nih.gov/articles/PMC8284293/0
2020Impact of pulsed magnetic field treatment on enzymatic inactivation and quality of cloudy apple juiceJingya Qian—https://link.springer.com/article/10.1007/s13197-020-04801-y0
2020Targeted Osmotic Lysis of Highly Invasive Breast Carcinomas Using Pulsed Magnetic Field Stimulation of Voltage-Gated Sodium Channels and Pharmacological Blockade of Sodium PumpsDennis PaulPMC7352419https://pmc.ncbi.nlm.nih.gov/articles/PMC7352419/0
2020Pulsed Low-Frequency Magnetic Fields Induce Tumor Membrane Disruption and Altered Cell ViabilityChristopher P AshdownPMC7136334https://pmc.ncbi.nlm.nih.gov/articles/PMC7136334/0
2020Pulsed Electromagnetic Fields Stimulate HIF-1α-Independent VEGF Release in 1321N1 Human Astrocytes Protecting Neuron-like SH-SY5Y Cells from Oxygen-Glucose DeprivationFabrizio VincenzPMC7663527https://pmc.ncbi.nlm.nih.gov/articles/PMC7663527/0
2020Electromagnetic Field in Alzheimer's Disease: A Literature Review of Recent Preclinical and Clinical StudiesReem Habib Mohamad Ali Ahmad33256578https://pubmed.ncbi.nlm.nih.gov/33256578/0
2020Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α LevelsHanie MahakiPMC7024597https://pmc.ncbi.nlm.nih.gov/articles/PMC7024597/0
2020Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer CellsAoshu XuPMC7215396https://pmc.ncbi.nlm.nih.gov/articles/PMC7215396/0
2020Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regenerationDinesh Parate—https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-1566-50
2020Therapeutic use of pulsed electromagnetic field therapy reduces prostate volume and lower urinary tract symptoms in benign prostatic hyperplasiaMarta TenutaPMC7496682https://pmc.ncbi.nlm.nih.gov/articles/PMC7496682/0
2019Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid ArthritisChristina L RossPMC6409305https://pmc.ncbi.nlm.nih.gov/articles/PMC6409305/0
2019Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injuryChunyan WangPMC6390012https://pmc.ncbi.nlm.nih.gov/articles/PMC6390012/0
2019Low-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex Enhances Recognition Memory in Alzheimer's DiseasePatrizia Turriziani31609693https://pubmed.ncbi.nlm.nih.gov/31609693/0
2019Low-frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injuryChunyan WangPMC6390012https://pmc.ncbi.nlm.nih.gov/articles/PMC6390012/0
2019The Use of Pulsed Electromagnetic Field to Modulate Inflammation and Improve Tissue Regeneration: A ReviewChristina L RossPMC8370292https://pmc.ncbi.nlm.nih.gov/articles/PMC8370292/0
2019Effects of exposure to extremely low-frequency electromagnetic fields on spatial and passive avoidance learning and memory, anxiety-like behavior and oxidative stress in male ratsSeyed Asaad Karimi30290199https://pubmed.ncbi.nlm.nih.gov/30290199/0
2019Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanismJasmine Lye Yee YapPMC6902701https://pmc.ncbi.nlm.nih.gov/articles/PMC6902701/0
2019The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shiftLoredana Bergandi—https://www.sciencedirect.com/science/article/pii/S01674889193009410
2018Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patientsNatalia Cichon30755096https://pubmed.ncbi.nlm.nih.gov/30755096/0
2018Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cellRichard HW FunkPMC5992548https://pmc.ncbi.nlm.nih.gov/articles/PMC5992548/0
2018Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patientsNatalia Cichoń30024661https://pubmed.ncbi.nlm.nih.gov/30024661/0
2018Low-intensity electromagnetic fields induce human cryptochrome to modulate intracellular reactive oxygen speciesRachel M SherrardPMC6168118https://pmc.ncbi.nlm.nih.gov/articles/PMC6168118/0
2018RKIP-Mediated NF-κB Signaling is involved in ELF-MF-mediated improvement in AD ratHongyan ZuoPMC6299414https://pmc.ncbi.nlm.nih.gov/articles/PMC6299414/0
2018Spatial memory recovery in Alzheimer's rat model by electromagnetic field exposureZeinab Akbarnejad29185809https://pubmed.ncbi.nlm.nih.gov/29185809/0
2018Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke PatientsNatalia Cichoń—https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2018.00294/full0
2018Exposure to a specific time-varying electromagnetic field inhibits cell proliferation via cAMP and ERK signaling in cancer cellsCarly A Buckner 29125193https://pubmed.ncbi.nlm.nih.gov/29125193/0
20186-mT 0-120-Hz magnetic fields differentially affect cellular ATP levelsDongmei Wang30074140https://pubmed.ncbi.nlm.nih.gov/30074140/0
2018A review on the use of magnetic fields and ultrasound for non-invasive cancer treatmentSomoshree SenguptaPMC6090088https://pmc.ncbi.nlm.nih.gov/articles/PMC6090088/0
2018Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro studyLetizia Ferroni—https://www.nature.com/articles/s41598-018-23499-90
2018Pulsed electromagnetic field induces Ca2+-dependent osteoblastogenesis in C3H10T1/2 mesenchymal cells through the Wnt-Ca2+/Wnt-β-catenin signaling pathwayShaoyu Wu29909008https://pubmed.ncbi.nlm.nih.gov/29909008/0
2018Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 CellsAlfredo Errico Provenzano—https://karger.com/cpb/article-pdf/46/1/389/2449782/000488473.pdf0
2017Emerging techniques in ‘truly’ minimal-invasive treatment options of benign prostatic obstructionKarl-Dietrich Sievert—https://www.researchgate.net/publication/315441115_Emerging_techniques_in_%27truly%27_minimal-invasive_treatment_options_of_benign_prostatic_obstruction0
2017Magnetic Fields and Reactive Oxygen SpeciesHuizhen Wang—https://www.mdpi.com/1422-0067/18/10/21750
2017Extremely low frequency electromagnetic field (ELF-EMF) reduces oxidative stress and improves functional and psychological status in ischemic stroke patientsNatalia Cichoń28430370https://pubmed.ncbi.nlm.nih.gov/28430370/0
2017Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke RehabilitationNatalia CichońPMC5613626https://pmc.ncbi.nlm.nih.gov/articles/PMC5613626/0
2017A Pulsed Electromagnetic Field Protects against Glutamate-Induced Excitotoxicity by Modulating the Endocannabinoid System in HT22 CellsXin Li—https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2017.00042/full0
2017Pulsed Electromagnetic Field Stimulation Promotes Anti-cell Proliferative Activity in Doxorubicin-treated Mouse Osteosarcoma CellsYOSHITAKA MURAMATSUPMC5354149https://pmc.ncbi.nlm.nih.gov/articles/PMC5354149/0
2017Pulsed electromagnetic field with or without exercise therapy in the treatment of benign prostatic hyperplasiaHany M ElgoharyPMC5574357https://pmc.ncbi.nlm.nih.gov/articles/PMC5574357/0
2017Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's diseaseJunli Zhen—https://www.sciencedirect.com/science/article/pii/S235287371730046X0
2017Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2Sabrina Ehnert—https://www.nature.com/articles/s41598-017-14983-90
2017Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?Olga ZeniPMC5651525https://pmc.ncbi.nlm.nih.gov/articles/PMC5651525/0
2016Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathwayBaihuan Feng26850078https://pubmed.ncbi.nlm.nih.gov/26850078/0
2016Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncologyMaria VadalàPMC5119968https://pmc.ncbi.nlm.nih.gov/articles/PMC5119968/0
2016Moderate and strong static magnetic fields directly affect EGFR kinase domain orientation to inhibit cancer cell proliferationLei ZhangPMC5173076https://pmc.ncbi.nlm.nih.gov/articles/PMC5173076/0
2016Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson's Disease Toxin MPP(.)Barbara Benassi26223801https://pubmed.ncbi.nlm.nih.gov/26223801/0
2016Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD miceYu Hu26945731https://pubmed.ncbi.nlm.nih.gov/26945731/0
2016Sub-millitesla magnetic field effects on the recombination reaction of flavin and ascorbic acid radicalsEmrys W. Evans—https://pubs.aip.org/aip/jcp/article/145/8/085101/561871/Sub-millitesla-magnetic-field-effects-on-the0
2016Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseasesFabio GuerrieroPMC5270416https://pmc.ncbi.nlm.nih.gov/articles/PMC5270416/0
2016How a High-Gradient Magnetic Field Could Affect Cell LifeVitalii ZablotskiiPMC5114642https://pmc.ncbi.nlm.nih.gov/articles/PMC5114642/0
2016EFFECT OF PULSED ELECTROMAGNETIC FIELDS ON ENDOPLASMIC RETICULUM STRESSE. KECZAN—https://www.jpp.krakow.pl/journal/archive/10_16/articles/14_article.html0
2016Novel protective effects of pulsed electromagnetic field ischemia/reperfusion injury ratsFenfen MaPMC5137536https://pmc.ncbi.nlm.nih.gov/articles/PMC5137536/0
2016The use of magnetic fields in treatment of patients with rheumatoid arthritis. Review of the literatureJolanta ZwolińskaPMC5090029https://pmc.ncbi.nlm.nih.gov/articles/PMC5090029/0
2016BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA DamageKatja StorchPMC5154536https://pmc.ncbi.nlm.nih.gov/articles/PMC5154536/0
2016Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric TissuesBahadır ÖztürkPMC4904108https://pmc.ncbi.nlm.nih.gov/articles/PMC4904108/0
2015Pre-exposure of neuroblastoma cell line to pulsed electromagnetic field prevents H2 O2 -induced ROS production by increasing MnSOD activityCecilia Osera25708841https://pubmed.ncbi.nlm.nih.gov/25708841/0
2015Inhibition of Cancer Cell Growth by Exposure to a Specific Time-Varying Electromagnetic Field Involves T-Type Calcium ChannelsCarly A BucknerPMC4397079https://pmc.ncbi.nlm.nih.gov/articles/PMC4397079/0
2015Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in ratsYemao Zhang25118893https://pubmed.ncbi.nlm.nih.gov/25118893/0
2015Overexpression of miR-26b-5p regulates the cell cycle by targeting CCND2 in GC-2 cells under exposure to extremely low frequency electromagnetic fieldsYong LiuPMC4943694https://pmc.ncbi.nlm.nih.gov/articles/PMC4943694/0
2015mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human KeratinocytesAntonia PatrunoPMC4592237https://pmc.ncbi.nlm.nih.gov/articles/PMC4592237/0
2014Electromagnetic field investigation on different cancer cell linesNenad Filipovic—https://link.springer.com/content/pdf/10.1186/s12935-014-0084-x.pdf0
2014Extremely Low-Frequency Electromagnetic Fields Cause G1 Phase Arrest through the Activation of the ATM-Chk2-p21 PathwayChao-Ying HuangPMC4128733https://pmc.ncbi.nlm.nih.gov/articles/PMC4128733/0
2014Optimization of a therapeutic electromagnetic field (EMF) to retard breast cancer tumor growth and vascularityIvan L CameronPMC4272545https://pmc.ncbi.nlm.nih.gov/articles/PMC4272545/0
2014Effect of pulsed electromagnetic field therapy on prostate volume and vascularity in the treatment of benign prostatic hyperplasia: a pilot study in a canine modelRaffaella LeociPMC4145661https://pmc.ncbi.nlm.nih.gov/articles/PMC4145661/0
2014Alternative radical pairs for cryptochrome-based magnetoreceptionAlpha A LeePMC4006233https://pmc.ncbi.nlm.nih.gov/articles/PMC4006233/0
2014The effects of pulsed magnetic field exposure on the permeability of leukemia cancer cellsZeinab Shankayi23781987https://pubmed.ncbi.nlm.nih.gov/23781987/0
2014Pulsed electromagnetic field enhances brain-derived neurotrophic factor expression through L-type voltage-gated calcium channel- and Erk-dependent signaling pathways in neonatal rat dorsal root ganglion neuronsYuan Li24937769https://pubmed.ncbi.nlm.nih.gov/24937769/0
2013Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)Simona Delle MonachePMC3828379https://pmc.ncbi.nlm.nih.gov/articles/PMC3828379/0
2013Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effectsMartin L PallPMC3780531https://pmc.ncbi.nlm.nih.gov/articles/PMC3780531/0
2013Low Intensity and Frequency Pulsed Electromagnetic Fields Selectively Impair Breast Cancer Cell ViabilitySara CrocettiPMC3770670https://pmc.ncbi.nlm.nih.gov/articles/PMC3770670/0
2012Time-varying magnetic fields of 60 Hz at 7 mT induce DNA double-strand breaks and activate DNA damage checkpoints without apoptosisJiyeon Kim 22180328https://pubmed.ncbi.nlm.nih.gov/22180328/0
2012Effect of 60 Hz electromagnetic fields on the activity of hsp70 promoter: an in vivo studyAbraham O Rodríguez-De la FuentePMC3476825https://pmc.ncbi.nlm.nih.gov/articles/PMC3476825/0
2012Effect of stationary magnetic field strengths of 150 and 200 mT on reactive oxygen species production in soybeanM B Shine22253132https://pubmed.ncbi.nlm.nih.gov/22253132/0
2011Modulation of Hydrogen Peroxide Production in Cellular Systems by Low Level Magnetic FieldsCarlos F MartinoPMC3162571https://pmc.ncbi.nlm.nih.gov/articles/PMC3162571/0
2011Effect of Magnetic Fields on Tumor Growth and ViabilityIvan TatarovPMC3155400https://pmc.ncbi.nlm.nih.gov/articles/PMC3155400/0
2011No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell linesDaguang Zhang21480303https://pubmed.ncbi.nlm.nih.gov/21480303/0
2010Effects of acute and chronic low frequency electromagnetic field exposure on PC12 cells during neuronal differentiationCaterina Morabito 21220925https://pubmed.ncbi.nlm.nih.gov/21220925/0
2010Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro studyJustus HW JansenPMC2936347https://pmc.ncbi.nlm.nih.gov/articles/PMC2936347/0
2010Pulsed Magnetic Field Induces Angiogenesis and Improves Cardiac Function of Surgically Induced Infarcted Myocardium in Sprague-Dawley RatsYuan Yuan20924179https://pubmed.ncbi.nlm.nih.gov/20924179/0
2010Effects of 50-Hz magnetic field exposure on superoxide radical anion formation and HSP70 induction in human K562 cellsAnn-Christine Mannerling 20582429https://pubmed.ncbi.nlm.nih.gov/20582429/0
2010Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cellsJiyeon Kim 20816755https://pubmed.ncbi.nlm.nih.gov/20816755/0
2009Amplitude-modulated electromagnetic fields for the treatment of cancer: Discovery of tumor-specific frequencies and assessment of a novel therapeutic approachAlexandre BarbaultPMC2672058https://pmc.ncbi.nlm.nih.gov/articles/PMC2672058/0
2009Static Magnetic Field Effect on the Fremy's Salt-Ascorbic Acid Chemical Reaction Studied by Continuous-Wave Electron Paramagnetic ResonanceNadia Catallo—https://www.researchgate.net/publication/40728270_Static_Magnetic_Field_Effect_on_the_Fremy's_Salt-Ascorbic_Acid_Chemical_Reaction_Studied_by_Continuous-Wave_Electron_Paramagnetic_Resonance0
2009Effects of Sinusoidal Magnetic Field Observed on Cell Proliferation, Ion Concentration, and Osmolarity in Two Human Cancer Cell LinesLingzhen Huang—https://www.tandfonline.com/doi/full/10.1080/153683706007190670
2008A 60-Hz sinusoidal magnetic field induces apoptosis of prostate cancer cells through reactive oxygen speciesEui Kwan Koh19016143https://pubmed.ncbi.nlm.nih.gov/19016143/0
2005A prospective, randomized, placebo controlled, double-blind study of pelvic electromagnetic therapy for the treatment of chronic pelvic pain syndrome with 1 year of followupE Rowe15879822https://pubmed.ncbi.nlm.nih.gov/15879822/0
2005Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasisIvan L CameronPMC1190196https://pmc.ncbi.nlm.nih.gov/articles/PMC1190196/0
2004Weak electromagnetic fields (50 Hz) elicit a stress response in human cells Sergey V Tokalov 14757377https://pubmed.ncbi.nlm.nih.gov/14757377/0
2004Differences in lethality between cancer cells and human lymphocytes caused by LF-electromagnetic fieldsMaria Radeva15376245https://pubmed.ncbi.nlm.nih.gov/15376245/0
2002Anticancer Activity by Magnetic Fields: Inhibition of Metastatic Spread and Growth in a Breast Cancer ModelSanti Tofani——0
2002Mechanism for action of electromagnetic fields on cellsDimitris J Panagopoulos12379225https://pubmed.ncbi.nlm.nih.gov/12379225/0
2001Therapeutic electromagnetic field effects on angiogenesis and tumor growthC D Williams 11911264https://pubmed.ncbi.nlm.nih.gov/11911264/0
2001Inhibition of proliferation of human lymphoma cells U937 by a 50 Hz electromagnetic fieldB Glück11936855https://pubmed.ncbi.nlm.nih.gov/11936855/0
2001Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cellsG P Pessina11568936https://pubmed.ncbi.nlm.nih.gov/11568936/0
2000Effect of low frequency, low amplitude magnetic fields on the permeability of cationic liposomes entrapping carbonic anhydrase: I. Evidence for charged lipid involvementA Ramundo-Orlando11015113pubmed.ncbi.nlm.nih.gov/11015113/0
2000A mechanism for action of oscillating electric fields on cellsD J Panagopoulos10860806https://pubmed.ncbi.nlm.nih.gov/10860806/0
1999Effects of exposure to repetitive pulsed magnetic stimulation on cell proliferation and expression of heat shock protein 70 in normal and malignant cellsG Tsurita10441487https://pubmed.ncbi.nlm.nih.gov/10441487/0
1994Non-ionizing Electromagnetic Radiation: A Study of Carcinogenic and Cancer Treatment PotentialJ R. Salvatore7724878https://pubmed.ncbi.nlm.nih.gov/7724878/0
1994Chemotherapy of human carcinoma xenografts during pulsed magnetic field exposureC J Hannan Jr7979179https://pubmed.ncbi.nlm.nih.gov/7979179/0
1991Effect of a 9 mT pulsed magnetic field on C3H/Bi female mice with mammary carcinoma. A comparison between the 12 Hz and the 460 Hz frequenciesA Bellossi 1932623https://pubmed.ncbi.nlm.nih.gov/1932623/0
1990Time-varying magnetic fields increase cytosolic free Ca2+ in HL-60 cells2221045https://pubmed.ncbi.nlm.nih.gov/2221045/0
1986Magnetic field-induced drug permeability in liposome vesiclesR P Liburdy—https://pubmed.ncbi.nlm.nih.gov/3774963/0
207Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer's DiseaseEnrica Capelli—https://pmc.ncbi.nlm.nih.gov/articles/PMC5434238/0
2025Rotating magnetic field improves cognitive and memory impairments in APP/PS1 mice by activating autophagy and inhibiting the PI3K/AKT/mTOR signaling pathwayMengqing L—https://pubmed.ncbi.nlm.nih.gov/39461710/0
2025The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's diseaseAnnibale Antonioni—https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70337?utm_source=chatgpt.com0
2024Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling PathwayGe ZhangPMC10900498https://pmc.ncbi.nlm.nih.gov/articles/PMC10900498/0
2024The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary studyElżbieta Cecerska-HeryćPMC11018782https://pmc.ncbi.nlm.nih.gov/articles/PMC11018782/0
2024Systematic simulation of tumor cell invasion and migration in response to time-varying rotating magnetic fieldShilong Zhang38801615https://pubmed.ncbi.nlm.nih.gov/38801615/0
2024Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma CellsYan MiPMC11117552https://pmc.ncbi.nlm.nih.gov/articles/PMC11117552/0
2024The Effect of a Rotating Magnetic Field on the Regenerative Potential of PlateletsElżbieta Cecerska-HeryćPMC11012199https://pmc.ncbi.nlm.nih.gov/articles/PMC11012199/0
2024Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarizationMengqing LiPMC11493917https://pmc.ncbi.nlm.nih.gov/articles/PMC11493917/0
2024The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic ReviewRenata MarchewkaPMC11119128https://pmc.ncbi.nlm.nih.gov/articles/PMC11119128/0
2024Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease miceRuo-Wen GuoRuo-Wen Guohttps://pmc.ncbi.nlm.nih.gov/articles/PMC11298676/0
2024Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticlesCristina Stavilă PhD student—https://www.sciencedirect.com/science/article/pii/S15499634240003520
2024Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer CellsCristina StavilăPMC11256100https://pmc.ncbi.nlm.nih.gov/articles/PMC11256100/0
2024Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice.Ruo-Wen Guo—https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-390210810
2024Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growthZhaoxian YanPMC11310191https://www.nature.com/articles/s41598-024-67437-4.pdf0
2023Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer MetastasisXinmiao JiPMC10017101https://pmc.ncbi.nlm.nih.gov/articles/PMC10017101/0
2023Biological effects of rotating magnetic field: A review from 1969 to 2021Yunpeng Wei36574882https://pubmed.ncbi.nlm.nih.gov/36574882/0
2023Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubesXIAN WANG—https://www.science.org/doi/10.1126/sciadv.ade53210
2023Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune DysfunctionsYu HanPMC10093245https://pmc.ncbi.nlm.nih.gov/articles/PMC10093245/0
2023Magnetically controlled cyclic microscale deformation of in vitro cancer invasion modelsDaphne Osk Asgeirsson—https://www.researchgate.net/publication/374768956_Magnetically_Controlled_Cyclic_Microscale_Deformation_of_In_Vitro_Cancer_Invasion_Models0
2023Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cellsShashank HambardePMC10630398https://pmc.ncbi.nlm.nih.gov/articles/PMC10630398/0
2022Method and apparatus for oncomagnetic treatmentHelekar et al—https://patents.google.com/patent/US12186575B2/en0
2022Rotating Magnetic Field-Assisted Reactor Enhances Mechanisms of Phage Adsorption on Bacterial Cell SurfaceBartłomiej GrygorcewiczPMC8947294https://pmc.ncbi.nlm.nih.gov/articles/PMC8947294/0
2022Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in miceShashank Hambarde36154345https://pubmed.ncbi.nlm.nih.gov/36154345/0
2022EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGEShashank HambardePMC9661114https://pmc.ncbi.nlm.nih.gov/articles/PMC9661114/0
2021Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic ImplicationsKatia VaraniPMC7830993https://pmc.ncbi.nlm.nih.gov/articles/PMC7830993/0
2021Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fieldsSara LopezPMC9417452https://pmc.ncbi.nlm.nih.gov/articles/PMC9417452/0
2021Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF)—An In Vitro Wound Healing StudyMagdalena Jedrzejczak-SilickaPMC8199476https://pmc.ncbi.nlm.nih.gov/articles/PMC8199476/0
2021Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fieldsSantosh A Helekar34477946https://pubmed.ncbi.nlm.nih.gov/34477946/0
2021Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer CellsMartyn A SharpePMC8631329https://pmc.ncbi.nlm.nih.gov/articles/PMC8631329/0
2021Case Report: End-Stage Recurrent Glioblastoma Treated With a New Noninvasive Non-Contact Oncomagnetic DeviceDavid S BaskinPMC8341943https://pmc.ncbi.nlm.nih.gov/articles/PMC8341943/0
2021Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trialsHuanhuan LvPMC7941227https://pmc.ncbi.nlm.nih.gov/articles/PMC7941227/0
2020Cancer treatment by magneto-mechanical effect of particles, a reviewCécile NaudPMC9419242https://pmc.ncbi.nlm.nih.gov/articles/PMC9419242/0
2020The efficacy and safety of low-frequency rotating static magnetic field therapy combined with chemotherapy on advanced lung cancer patients: a randomized, double-blinded, controlled clinical trialMinghui Zhu32238091https://pubmed.ncbi.nlm.nih.gov/32238091/0
2020Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistanceYao Chenyang—https://m.x-mol.net/paper/article/13077384348683182080
2020Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibitionYong Qian—https://www.sciencedirect.com/science/article/abs/pii/S13858947203195130
2020Study on the Effect of Rotating Magnetic Field on Cellular Response of Mammalian CellsMagdalena Jędrzejczak-Silicka—https://www.researchgate.net/publication/341242877_Study_on_the_Effect_of_Rotating_Magnetic_Field_on_Cellular_Response_of_Mammalian_Cells0
2020Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17Tianying ZhanPMC7185125https://pmc.ncbi.nlm.nih.gov/articles/PMC7185125/0
2019Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegansJiangyao Xu—https://www.researchgate.net/publication/337466667_Rotating_magnetic_field_delays_human_umbilical_vein_endothelial_cell_aging_and_prolongs_the_lifespan_of_Caenorhabditis_elegans0
2018Effect of low-frequency rotary magnetic fields on advanced gastric cancerChen, Zheng29970658https://journals.lww.com/cancerjournal/fulltext/2018/14040/effect_of_low_frequency_rotary_magnetic_fields_on.15.aspx0
2018Application of Rotating Magnetic Fields Increase the Activity of Antimicrobials Against Wound Biofilm PathogensA. F. Junka—https://www.nature.com/articles/s41598-017-18557-70
2017Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling PathwayYujun XuPMC5603574https://pmc.ncbi.nlm.nih.gov/articles/PMC5603574/0
2017LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathwayJing RenPMC5429732https://pmc.ncbi.nlm.nih.gov/articles/PMC5429732/0
2017Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic FieldYajing ShenPMC5436524https://pmc.ncbi.nlm.nih.gov/articles/PMC5436524/0
2016Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in miceMeng Zha30142006https://www.researchgate.net/publication/327213612_Moderate_intensity_low_frequency_rotating_magnetic_field_inhibits_breast_cancer_growth_in_mice0
2016Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: Potential role for ROS-mediated inhibition on AKTRuijing Tang26807660https://pubmed.ncbi.nlm.nih.gov/26807660/0
2016Early exposure of rotating magnetic fields promotes central nervous regeneration in planarian Girardia sinensisQiang Chen27061713https://pubmed.ncbi.nlm.nih.gov/27061713/0
2015Rotating Magnetic Field Induced Oscillation of Magnetic Particles for in vivo Mechanical Destruction of Malignant GliomaYu ChengPMC4724455https://pmc.ncbi.nlm.nih.gov/articles/PMC4724455/0
2015Modification of bacterial cellulose through exposure to the rotating magnetic fieldKarol Fijałkowski26344254https://pubmed.ncbi.nlm.nih.gov/26344254/0
2014Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cellsLeilei Du25196555https://pubmed.ncbi.nlm.nih.gov/25196555/0
2013Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular CarcinomaYunzhong NiePMC3835892https://pmc.ncbi.nlm.nih.gov/articles/PMC3835892/0
2013Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulationYunzhong NiePMC4029221https://pmc.ncbi.nlm.nih.gov/articles/PMC4029221/0
2012A pilot study of extremely low-frequency magnetic fields in advanced non-small cell lung cancer: Effects on survival and palliation of general symptomsCHENGTAO SUNPMC3499610https://pmc.ncbi.nlm.nih.gov/articles/PMC3499610/0
2011Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cellsTingting Wang21360556https://pubmed.ncbi.nlm.nih.gov/21360556/0
2008The expression and intranuclear distribution of nucleolin in HL-60 and K-562 cells after repeated, short-term exposition to rotating magnetic fieldsMarek Masiuk18821389https://pubmed.ncbi.nlm.nih.gov/18821389/0
2006Effects of 0.4 T Rotating Magnetic Field Exposure on Density, Strength, Calcium and Metabolism of Rat Thigh BonesXiao-yun Zhang—http://www.zgkjcx.com/Article/UploadFiles/200807/20080710121302169.pdf0
2001Molecular mechanism of effect of rotating constant magnetic field on organismsX Zhang18726401https://pubmed.ncbi.nlm.nih.gov/18726401/0
2001The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer CellsNina Mikirova, Ph.D.—https://isom.ca/wp-content/uploads/2020/01/JOM_2001_16_3_10_The_Effect_of_Alternating_Magnetic_Field_Exposure_and-.pdf0
1993The effect of rotating magnetic fields on the growth of Deal's guinea pig sarcoma transplanted subcutaneously in guinea pigsE Schwartz8353767https://pubmed.ncbi.nlm.nih.gov/8353767/0
2016Effects of combined delivery of extremely low frequency electromagnetic field and magnetic Fe3O4 nanoparticles on hepatic cell linesHuixiang JuPMC4859912https://pmc.ncbi.nlm.nih.gov/articles/PMC4859912/0
2020Preparation of magnetic nanoparticle integrated nanostructured lipid carriers for controlled delivery of ascorbyl palmitateGokce Dicle KalayciogluPMC7691729https://pmc.ncbi.nlm.nih.gov/articles/PMC7691729/0
2014Effect of Magnetic Field on Ascorbic Acid Oxidase Activity, IV. S. Ghole —https://www.researchgate.net/publication/303016925_Effect_of_Magnetic_Field_on_Ascorbic_Acid_Oxidase_Activity_I0
2011Extremely low frequency magnetic field induces oxidative stress in mouse cerebellumLi Y Chu22131325https://pubmed.ncbi.nlm.nih.gov/22131325/0
2007Protective Effect of Ascorbic Acid on Molecular Behavior Changes of Hemoglobin Induced by Magnetic Field Induced by Magnetic FieldNahed S. Hassan—https://www.researchgate.net/publication/46028576_Protective_Effect_of_Ascorbic_Acid_on_Molecular_Behavior_Changes_of_Hemoglobin_Induced_by_Magnetic_Field_Induced_by_Magnetic_Field0