tbResList Print — Bical Bicalutamide

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Product

Bical Bicalutamide
Description: <b>Bicalutamide</b> brand name Casodex. An antiandrogen medication that is primarily used to treat prostate cancer.<br>

Pathway results for Effect on Cancer / Diseased Cells

Mitochondria & Bioenergetics ⓘ

MEK↑, 1,  

Cell Death ⓘ

p‑JNK↓, 1,  

DNA Damage & Repair ⓘ

SAPK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   TumCG↓, 1,  

Migration ⓘ

MUC1↓, 1,  

Immune & Inflammatory Signaling ⓘ

p65↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,  

Functional Outcomes ⓘ

Remission↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2014Complete Response of Metastatic Androgen Receptor–Positive Breast Cancer to Bicalutamide: Case Report and Review of the LiteratureClaudia Arce-Salinas—https://ascopubs.org/doi/abs/10.1200/jco.2013.49.88990
2015Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-CJing LiPMC4446835https://pmc.ncbi.nlm.nih.gov/articles/PMC4446835/0