tbResList Print — NRF nelfinavir/Viracept

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Product

NRF nelfinavir/Viracept
Description: <b>NRF</b> is an antiretroviral medication used in the treatment of HIV/AIDS.<br>
Nelfinavir belongs to the class of drugs known as protease inhibitors and like other PIs is almost always used in combination with other antiretroviral drugs.<br>

Pathway results for Effect on Cancer / Diseased Cells

Cell Death ⓘ

p‑Akt↓, 1,   BID↑, 1,   Casp3↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,   XBP-1↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Migration ⓘ

TRIB3↑, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

TRIB3↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2014Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer CellsAditi MathurPMC4133210https://pmc.ncbi.nlm.nih.gov/articles/PMC4133210/0