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MFrot Magnetic Field Rotating

Description: Magnetic Field Rotating — Rotating magnetic field (RMF) is a dynamic magnetic-field modality in which the magnetic-field vector rotates spatially with time, generated either by mechanically rotating permanent magnets or by phase-shifted orthogonal electromagnetic coils. Related implementations include spinning oscillating magnetic fields (sOMF/OMF), gradient rotating magnetic fields, rotating static magnetic fields, and nanoparticle-coupled magnetomechanical RMF. The Oncomagnetic platform is an important cancer-specific implementation in which rapidly rotating permanent magnets generate patterned sOMF without requiring magnetic nanoparticles. RMF should be distinguished from generic static magnetic fields, conventional alternating magnetic fields, pulsed electromagnetic fields, and transcranial magnetic stimulation because field geometry, rotation, frequency, amplitude, temporal pattern, and mechanical coupling substantially affect biological responses.

Primary mechanisms (ranked):
<ol>
<li>Mitochondrial electron-transport disruption, particularly persistent inhibition of Complex I in Oncomagnetic sOMF-treated cancer cells.</li>
<li>Tumor-selective mitochondrial ROS generation and oxidative stress downstream of disturbed electron transport.</li>
<li>Mitochondrial depolarization, respiratory failure, mitochondrial permeability transition, and subsequent apoptotic signaling.</li>
<li>Oxidative DNA damage, G1 cell-cycle arrest, and caspase-dependent apoptosis following sustained Oncomagnetic exposure.</li>
<li>F-actin and cytoskeletal mechanotransduction, reducing migration, invasion, and metastasis with moderate-intensity or gradient RMF.</li>
<li>ECM-integrin signaling modulation, including COL11A1/ITGB1/FAK/YAP and CCDC150/TGF-β1/SMAD3 pathways in triple-negative breast cancer models.</li>
<li>Magnetomechanical membrane, cytoskeletal, lysosomal, or organelle disruption when RMF is combined with internalized magnetic nanoparticles; this mechanism requires magnetic material and is mechanistically distinct from particle-free Oncomagnetic therapy.</li>
</ol>

Bioavailability / PK relevance: Not concentration-driven. RMF is a physical-field modality and therefore has no conventional absorption, plasma concentration, metabolism, or elimination. Therapeutic exposure instead depends on field strength, rotation frequency, spatial gradient, vector geometry, temporal pattern, tissue penetration, distance from the field source, and treatment duration. Nanoparticle-assisted RMF additionally depends on particle biodistribution, tumor uptake, intracellular localization, retention, clearance, and magnetic susceptibility.

In-vitro vs systemic exposure relevance: Conventional concentration comparisons are not applicable. Translation depends on reproducing the relevant magnetic-field waveform and geometry within tissue. Oncomagnetic sOMF is specifically designed for non-contact field exposure without injected magnetic material, whereas many magnetomechanical RMF studies require nanoparticles and therefore should not be extrapolated to particle-free RMF. Field parameters from one RMF platform should not automatically be generalized to another.

Clinical evidence status: Preclinical evidence is substantial but heterogeneous, including cultured cancer cells, glioma and breast-cancer animal models, and nanoparticle-assisted magnetomechanical systems. Human evidence remains limited. Historical small clinical studies have evaluated rotating magnetic-field approaches in advanced cancers, and published Oncomagnetic compassionate-use case reports describe prolonged treatment of individual malignant glioma patients. A prospective multicenter Oncomagnetic study in newly diagnosed glioblastoma is currently recruiting, making the modality investigational rather than an established cancer treatment. The strongest contemporary mechanistic evidence is for glioma Oncomagnetic sOMF and for metastasis-modulating RMF in breast-cancer models.

Rotary Magnetic field can be generated by a spinning magnet or magnets. Or it can be implemented with 2 or more coils, power with a phase shift between them (90 deg for 2 coil implementation) (60deg for 3 coil implementation) 
Targets affected are mostly the same as for <a href="tbResList.php?qv=172&exPr=open">Magnet fields</a> 
Main differences 
- may enhance the EPR effect allowing targeting of drugs to cancer cells 
- acts as wireless stirrer, especially on magnetic particles(inducing eddy currents in water media) 
- research for use in nano surgery, and mechanical destruction of cancer cells 
- continue to highlight ability to raise ROS in cancer cell and lower ROS in normal cells 
- RMF may be responsible for Ca2+ distribution to pass across the plasma membrane(differental affected for cancer and normal cells) 

 
Pathways: 


- induce
<a href="tbResList.php?qv=192&tsv=275&wNotes=on">ROS</a> production in cancer cells,
while decreasing ROS in normal cells. Ca2+ is critical and the Ca2+ balance is increased in cancer
cells while decreased in normal cells (example for wound healing) 
- ROS↑ related:
<a href="tbResList.php?qv=192&tsv=197&wNotes=on&word=MMP↓">MMP↓</a>(ΔΨm),



<a href="tbResList.php?qv=192&tsv=38&wNotes=on&word=Ca+2↑">Ca+2↑</a>,
<a href="tbResList.php?qv=192&tsv=77&wNotes=on">Cyt‑c↑</a>,
<a href="tbResList.php?qv=192&wNotes=on&word=Casp">Caspases↑</a>,
<a href="tbResList.php?qv=192&tsv=82&wNotes=on&word=DNAdam↑">DNA damage↑</a>,
<a href="tbResList.php?qv=192&tsv=239&wNotes=on">cl-PARP↑</a>,
<a href="tbResList.php?qv=192&wNotes=on&word=HSP">HSP↓</a>,
<a href="tbResList.php?qv=192&wNotes=on&word=Prx">Prx</a>,

 




- Raises
<a href="tbResList.php?qv=192&tsv=1103&wNotes=on&word=antiOx↑">AntiOxidant</a>
defense in Normal Cells:
<a href="tbResList.php?qv=192&tsv=275&wNotes=on&word=ROS↓">ROS↓</a>,
<a href="tbResList.php?qv=192&tsv=226&wNotes=on&word=NRF2↑">NRF2↑</a>,
<a href="tbResList.php?qv=192&tsv=298&wNotes=on&word=SOD↑">SOD↑</a>,
<a href="tbResList.php?qv=192&tsv=137&wNotes=on&word=GSH↑">GSH↑</a>,
<a href="tbResList.php?qv=192&tsv=46&wNotes=on&word=Catalase↑">Catalase↑</a>,

 


- lowers
<a href="tbResList.php?qv=192&tsv=953&wNotes=on&word=Inflam">Inflammation</a> :
<a href="tbResList.php?qv=192&tsv=214&wNotes=on&word=NF-kB↓">NF-kB↓</a>,
<a href="tbResList.php?qv=192&tsv=66&wNotes=on&word=COX2↓">COX2↓</a>,
<a href="tbResList.php?qv=192&tsv=235&wNotes=on&word=p38↓">p38↓</a>, Pro-Inflammatory Cytokines :


<a href="tbResList.php?qv=192&tsv=309&wNotes=on&word=TNF-α↓">TNF-α↓</a>,
<a href="tbResList.php?qv=192&tsv=158&wNotes=on&word=IL6↓">IL-6↓</a>,

 


- inhibit Growth/Metastases :
<a href="tbResList.php?qv=192&tsv=604&wNotes=on">TumMeta↓</a>,
<a href="tbResList.php?qv=192&tsv=323&wNotes=on">TumCG↓</a>,

<a href="tbResList.php?qv=192&tsv=204&wNotes=on">MMPs↓</a>,
<a href="tbResList.php?qv=192&tsv=201&wNotes=on">MMP2↓</a>,
<a href="tbResList.php?qv=192&tsv=203&wNotes=on">MMP9↓</a>,

<a href="tbResList.php?qv=192&tsv=415&wNotes=on">IGF-1↓</a>,




<a href="tbResList.php?qv=192&tsv=273&wNotes=on">RhoA↓</a>,
<a href="tbResList.php?qv=192&tsv=214&wNotes=on">NF-κB↓</a>,


<a href="tbResList.php?qv=192&tsv=304&wNotes=on">TGF-β↓</a>,

<a href="tbResList.php?qv=192&tsv=105&wNotes=on">ERK↓</a>
 
 





- cause Cell cycle arrest :
<a href="tbResList.php?qv=192&tsv=322&wNotes=on">TumCCA↑</a>,





 


- inhibits Migration/Invasion :
<a href="tbResList.php?qv=192&tsv=326&wNotes=on">TumCMig↓</a>,
<a href="tbResList.php?qv=192&tsv=324&wNotes=on">TumCI↓</a>,
<a href="tbResList.php?qv=192&tsv=309&wNotes=on&word=TNF-α↓">TNF-α↓</a>, 

<a href="tbResList.php?qv=192&tsv=105&wNotes=on">ERK↓</a>,



 











- Others: <a href="tbResList.php?qv=192&tsv=252&wNotes=on">PI3K↓</a>,
<a href="tbResList.php?qv=192&tsv=4&wNotes=on">AKT↓</a>,


<a href="tbResList.php?qv=192&tsv=377&wNotes=on">Wnt↓</a>,

<a href="tbResList.php?qv=192&tsv=9&wNotes=on">AMPK</a>,

<a href="tbResList.php?qv=192&tsv=105&wNotes=on">ERK↓</a>,

<a href="tbResList.php?qv=192&tsv=168&wNotes=on">JNK</a>,

 


- Synergies:


<

<a href="tbResList.php?qv=192&tsv=961&esv=2&wNotes=on&exSp=open">Others(review target notes)</a>,
<a href="tbResList.php?qv=192&tsv=1105&wNotes=on">Neuroprotective</a>,
<a href="tbResList.php?qv=192&tsv=557&wNotes=on">Cognitive</a>,




 
 

- Selectivity:
<a href="tbResList.php?qv=192&tsv=1110&wNotes=on">Cancer Cells vs Normal Cells</a> 
 

<h3>Rotating Magnetic Field Cancer Mechanisms</h3>
<table border="1" cellspacing="0" cellpadding="4">
<tr>
<th>Rank</th>
<th>Pathway / Axis</th>
<th>Cancer Cells</th>
<th>Normal Cells</th>
<th>TSF</th>
<th>Primary Effect</th>
<th>Notes / Interpretation</th>
</tr>

<tr>
<td>1</td>
<td>Mitochondrial Complex I and electron transport</td>
<td>↓ Complex I activity; ↓ NADH:ubiquinone oxidoreductase function; ↓ mitochondrial electron transport</td>
<td>↔ no comparable persistent inhibition demonstrated in tested normal astrocytes and astroglial cells</td>
<td>P, R</td>
<td>Upstream metabolic disruption</td>
<td>Current Oncomagnetic sOMF evidence identifies ROS-dependent persistent Complex I inhibition as an immediate intracellular mechanism. This provides a mechanistic link between the rotating field and subsequent oxidative injury.</td>
</tr>

<tr>
<td>2</td>
<td>Mitochondrial ROS and oxidative stress</td>
<td>↑ superoxide; ↑ intracellular ROS; ↑ oxidative stress</td>
<td>↔ substantially smaller response in tested normal-cell models</td>
<td>P, R</td>
<td>Selective oxidative injury</td>
<td>A core Oncomagnetic mechanism. Rotation plus field oscillation produces substantially greater ROS than comparable static-field exposure in glioma models. Antioxidant rescue strongly supports a causal role for ROS.</td>
</tr>

<tr>
<td>3</td>
<td>Mitochondrial membrane integrity and permeability</td>
<td>↓ mitochondrial function; ↓ membrane integrity; ↑ permeability transition and mitochondrial injury (context-dependent)</td>
<td>↔ comparatively resistant in tested normal cells</td>
<td>R</td>
<td>Bioenergetic collapse</td>
<td>Occurs downstream of disturbed respiratory-chain redox chemistry and ROS. Strength of direct evidence varies by RMF implementation.</td>
</tr>

<tr>
<td>4</td>
<td>Glutathione redox system</td>
<td>↓ reduced GSH availability; ↑ GSH oxidation; ↑ GSSG/GSH ratio; ↓ reducing capacity</td>
<td>↔ lower oxidative burden in tested normal-cell models</td>
<td>R</td>
<td>Weakens antioxidant buffering</td>
<td>Directly relevant to the oxidative mechanism. GSH oxidation means reduced GSH is consumed as it is converted toward GSSG; this should not automatically be interpreted as a decrease in total cellular glutathione unless total glutathione was measured.</td>
</tr>

<tr>
<td>5</td>
<td>DNA oxidative damage and cell-cycle control</td>
<td>↑ oxidative DNA damage; ↑ G1 arrest; ↓ proliferation</td>
<td>↔ little comparable damage reported in tested normal astroglial cells</td>
<td>R, G</td>
<td>Cytostatic and genotoxic response</td>
<td>Downstream of sOMF-induced oxidative stress rather than evidence for a direct magnetic interaction with DNA.</td>
</tr>

<tr>
<td>6</td>
<td>Caspase-dependent apoptosis</td>
<td>↑ caspase activation; ↑ apoptosis; ↓ clonogenic survival</td>
<td>↔ comparatively low toxicity in tested normal-cell systems</td>
<td>R, G</td>
<td>Cancer-cell death</td>
<td>Oncomagnetic sOMF produces ROS-dependent loss of clonogenic survival and delayed caspase activation. Antioxidant rescue supports oxidative stress as the upstream driver.</td>
</tr>

<tr>
<td>7</td>
<td>F-actin and cytoskeletal mechanotransduction</td>
<td>↓ F-actin organization; ↓ spreading; ↓ migration; ↓ invasion</td>
<td>↔ insufficient comparative evidence</td>
<td>R, G</td>
<td>Suppresses invasive behavior</td>
<td>Particularly relevant to moderate-intensity and gradient RMF studies in triple-negative breast cancer. This represents a mechanomechanical branch distinct from the mitochondrial Oncomagnetic mechanism.</td>
</tr>

<tr>
<td>8</td>
<td>Mechanosensitive Ca²⁺ signaling</td>
<td>↑ or altered Ca²⁺ influx and oscillatory dynamics (context-dependent); altered Ca²⁺-dependent signaling</td>
<td>↔ insufficient comparative cancer-specific evidence</td>
<td>P, R</td>
<td>Mechanotransduction and signaling modulation</td>
<td>Rotating fields can alter predicted Ca²⁺ oscillatory dynamics through mechanosensitive-channel coupling. Direct experimental cancer-specific RMF evidence remains less mature than the ROS and mitochondrial evidence, so Ca²⁺ should be retained but ranked as secondary.</td>
</tr>

<tr>
<td>9</td>
<td>CCDC150 TGF-β1 SMAD3 axis</td>
<td>↓ CCDC150; ↓ TGF-β1/SMAD3 signaling; ↓ migration; ↓ invasion; ↓ metastasis</td>
<td>↔ insufficient comparative evidence</td>
<td>G</td>
<td>Antimetastatic signaling</td>
<td>Directly demonstrated with gradient RMF in triple-negative breast cancer models and closely linked to RMF-induced F-actin disruption.</td>
</tr>

<tr>
<td>10</td>
<td>COL11A1 ITGB1 FAK YAP axis</td>
<td>↓ COL11A1; ↓ ITGB1 signaling; ↓ FAK/YAP activation; ↓ tumor growth; ↓ lung metastasis</td>
<td>↔ insufficient comparative evidence</td>
<td>G</td>
<td>Suppresses ECM-driven metastatic signaling</td>
<td>Recent RMF-specific TNBC work identifies COL11A1 as an RMF-responsive extracellular-matrix component upstream of ITGB1/FAK/YAP signaling.</td>
</tr>

<tr>
<td>11</td>
<td>Magnetomechanical nanoparticle actuation</td>
<td>↑ mechanical membrane, cytoskeletal, lysosomal, or organelle injury (requires external trigger)</td>
<td>↔ strongly dependent on nanoparticle uptake and intracellular localization</td>
<td>P, R</td>
<td>Mechanical tumor-cell injury</td>
<td>Requires magnetic nanoparticles, nanomotors, or related magnetic structures. It is a genuine rotating-field mechanism but should be distinguished from particle-free Oncomagnetic sOMF.</td>
</tr>

<tr>
<td>12</td>
<td>GSH GPX4 ferroptosis axis</td>
<td>↓ GSH; ↓ GPX4; ↑ lipid ROS; ↑ lipid peroxidation; ↑ ferroptosis (requires external trigger)</td>
<td>↔ model-dependent</td>
<td>R, G</td>
<td>Ferroptotic cell death</td>
<td>Relevant primarily to RMF-driven magnetic nanoparticle and nanorobot systems. Current evidence does not establish GPX4 suppression as a general particle-free Oncomagnetic mechanism.</td>
</tr>

<tr>
<td>13</td>
<td>NRF2 antioxidant response</td>
<td>Potential ↑ compensatory NRF2 signaling following oxidative stress (context-dependent)</td>
<td>↔ insufficient RMF-specific comparative evidence</td>
<td>R, G</td>
<td>Adaptive antioxidant defense</td>
<td>NRF2 is mechanistically relevant to the oxidative-stress response, but direct rotating-field-specific evidence remains limited. ROS elevation should not be interpreted as NRF2 suppression; compensatory NRF2 activation is biologically plausible.</td>
</tr>

<tr>
<td>14</td>
<td>Tumor microenvironment mechanics</td>
<td>↓ matrix stiffness; altered CAF mechanics; ↑ immune-cell infiltration (model-dependent) (requires external trigger)</td>
<td>↔ model-dependent</td>
<td>R, G</td>
<td>Microenvironment remodeling</td>
<td>Reported mainly in RMF-driven magnetic nanomotor systems rather than particle-free RMF.</td>
</tr>

<tr>
<td>15</td>
<td>Chemosensitization</td>
<td>↑ treatment response in selected combination systems (context-dependent) (requires external trigger)</td>
<td>↔ insufficient comparative evidence</td>
<td>R, G</td>
<td>Combination-treatment enhancement</td>
<td>Evidence is currently stronger for nanoparticle-mediated RMF combinations than for particle-free Oncomagnetic therapy. RMF should not yet be described as a general chemosensitizer.</td>
</tr>

<tr>
<td>16</td>
<td>Clinical Translation Constraint</td>
<td>Response depends on waveform, rotation, field amplitude, frequency, gradient, geometry, treatment duration, tumor type, and nanoparticle use</td>
<td>Long-term human safety and comparative normal-tissue data remain limited</td>
<td>P, R, G</td>
<td>Limits cross-platform extrapolation</td>
<td>Oncomagnetic sOMF, gradient RMF, moderate-intensity RMF, and nanoparticle-assisted magnetomechanical RMF are related but mechanistically non-equivalent. ER stress and TrxR effects are not included as independent rows because current rotating-field-specific cancer evidence is insufficient to establish them as direct RMF mechanisms.</td>
</tr>
</table>
P: 0–30 min    R: 30 min–3 hr    G: >3 hr

MPTP: opening represents a mitochondrial commitment event integrating ROS and Ca²⁺ stress; sustained opening indicates irreversible bioenergetic failure. 

 
<hr>
 

Alzheimer’s disease relevance: Moderate-intensity rotating magnetic fields have shown disease-modifying effects in mouse models of Alzheimer’s disease. Reported effects include direct inhibition of Aβ fibril formation, reduced cerebral amyloid deposition, reduced microglial activation and oxidative stress, improved cognition and memory, and increased autophagic signaling with suppression of the PI3K/AKT/mTOR pathway. These findings are preclinical; they do not establish clinical efficacy in human Alzheimer’s disease.

Clinical status: Preclinical animal evidence only for the specifically rotating-field studies. Generic rTMS, PEMF, static-field, and other non-rotating magnetic-field studies should remain under the separate Magnetic Fields category rather than being used to establish RMF clinical efficacy.

<h3>Rotating Magnetic Field Alzheimer’s Mechanisms</h3>
<table border="1" cellspacing="0" cellpadding="4">
<tr>
<th>Rank</th>
<th>Pathway / Axis</th>
<th>AD Modulation</th>
<th>Primary Effect</th>
<th>Notes / Interpretation</th>
</tr>

<tr>
<td>1</td>
<td>Aβ aggregation and amyloid deposition</td>
<td>↓ Aβ fibril formation; ↓ amyloid plaques</td>
<td>Reduces amyloid burden</td>
<td>RMF can directly interfere with Aβ aggregation in vitro and reduced amyloid deposition in APP/PS1 mice.</td>
</tr>

<tr>
<td>2</td>
<td>Autophagy PI3K AKT mTOR</td>
<td>↑ autophagy; ↓ PI3K/AKT/mTOR signaling</td>
<td>Promotes proteostatic clearance</td>
<td>Long-term RMF exposure in APP/PS1 mice improved cognition and was associated with activation of autophagy-related pathways.</td>
</tr>

<tr>
<td>3</td>
<td>Microglial activation and neuroinflammation</td>
<td>↓ pathological microglial activation; polarization shifted toward protective phenotype</td>
<td>Reduces neuroinflammatory injury</td>
<td>Observed in both familial and sporadic mouse AD models.</td>
</tr>

<tr>
<td>4</td>
<td>Oxidative stress</td>
<td>↓ oxidative stress</td>
<td>Neuroprotection</td>
<td>Direction differs from the deliberate ROS increase observed in Oncomagnetic cancer cells, illustrating strong disease- and cell-state dependence.</td>
</tr>

<tr>
<td>5</td>
<td>Neuronal integrity</td>
<td>↑ neuronal survival and functional preservation</td>
<td>Neuroprotection</td>
<td>Associated with reduced neuronal damage in RMF-treated AD mice.</td>
</tr>

<tr>
<td>6</td>
<td>Cognition and memory</td>
<td>↑ spatial memory; ↑ recognition memory; ↑ cognitive performance</td>
<td>Functional improvement</td>
<td>Repeatedly reported in RMF-treated mouse models, but human efficacy remains unestablished.</td>
</tr>
</table>

Year	Title	Authors	PMID	Link
2026	Therapeutic Magnetic Fields in Oncology: A Systematic Review of Safety and Supportive Clinical Use	Saverio Colonna	PMC12921648	https://pmc.ncbi.nlm.nih.gov/articles/PMC12921648/
2026	Neuroprotective effect of RMF in a mouse model of sporadic Parkinson's disease	Umer Anayyat	41862117	https://pubmed.ncbi.nlm.nih.gov/41862117/
2026	Dual-targeting by rotating magnetic field-driven superparamagnetic bionic nanorobots for enhanced triple-negative breast cancer therapy	Wei Song	—	https://link.springer.com/article/10.1631/bdm.2500656
2026	Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity	Yingze Li	PMC12909937	https://pmc.ncbi.nlm.nih.gov/articles/PMC12909937/
2026	Inhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells	Shashank Hambarde	41510612	https://pubmed.ncbi.nlm.nih.gov/41510612/
2026	Rotating magnetic field downregulating type XI collagen to suppress triple-negative breast cancer metastasis by inactivating the ITGB1/FAK/YAP signaling pathway	Tongyao Yu	—	https://www.sciencedirect.com/science/article/abs/pii/S0141813025102341
2025	Urchin-like magnetic nanoparticles loaded with type X collagen siRNA and Stattic to treat triple negative breast cancer under rotating magnetic field like an "enchanted micro-scalpel"	Jie Liu	39864683	https://pubmed.ncbi.nlm.nih.gov/39864683/
2025	Actin-Targeted Magnetic Nanomotors Mechanically Modulate the Tumor Mechanical Microenvironment for Cancer Treatment	Xing Fan	39915111	https://pubmed.ncbi.nlm.nih.gov/39915111/
2025	Case Report: A new noninvasive device-based treatment of a mesencephalic H3 K27M glioma	Santosh A Helekar	PMC12626803	https://pmc.ncbi.nlm.nih.gov/articles/PMC12626803/
2025	The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease	Annibale Antonioni	—	https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.70337?utm_source=chatgpt.com
2025	Rotating magnetic field improves cognitive and memory impairments in APP/PS1 mice by activating autophagy and inhibiting the PI3K/AKT/mTOR signaling pathway	Mengqing L	—	https://pubmed.ncbi.nlm.nih.gov/39461710/
2024	Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma Cells	Yan Mi	PMC11117552	https://pmc.ncbi.nlm.nih.gov/articles/PMC11117552/
2024	Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growth	Zhaoxian Yan	PMC11310191	https://www.nature.com/articles/s41598-024-67437-4.pdf
2024	Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice.	Ruo-Wen Guo	—	https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39021081
2024	Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells	Cristina Stavilă	PMC11256100	https://pmc.ncbi.nlm.nih.gov/articles/PMC11256100/
2024	Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles	Cristina Stavilă PhD student	—	https://www.sciencedirect.com/science/article/pii/S1549963424000352
2024	The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets	Elżbieta Cecerska-Heryć	PMC11012199	https://pmc.ncbi.nlm.nih.gov/articles/PMC11012199/
2024	The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review	Renata Marchewka	PMC11119128	https://pmc.ncbi.nlm.nih.gov/articles/PMC11119128/
2024	Polyhedral magnetic nanoparticles induce apoptosis in gastric cancer stem cells and suppressing tumor growth through magnetic force generation	Jianhua Wang	—	https://www.sciencedirect.com/science/article/abs/pii/S0168365924004887
2024	Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice	Ruo-Wen Guo	Ruo-Wen Guo	https://pmc.ncbi.nlm.nih.gov/articles/PMC11298676/
2024	Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway	Ge Zhang	PMC10900498	https://pmc.ncbi.nlm.nih.gov/articles/PMC10900498/
2024	Systematic simulation of tumor cell invasion and migration in response to time-varying rotating magnetic field	Shilong Zhang	38801615	https://pubmed.ncbi.nlm.nih.gov/38801615/
2024	Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization	Mengqing Li	PMC11493917	https://pmc.ncbi.nlm.nih.gov/articles/PMC11493917/
2024	The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study	Elżbieta Cecerska-Heryć	PMC11018782	https://pmc.ncbi.nlm.nih.gov/articles/PMC11018782/
2023	Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells	Shashank Hambarde	PMC10630398	https://pmc.ncbi.nlm.nih.gov/articles/PMC10630398/
2023	Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions	Yu Han	PMC10093245	https://pmc.ncbi.nlm.nih.gov/articles/PMC10093245/
2023	Biological effects of rotating magnetic field: A review from 1969 to 2021	Yunpeng Wei	36574882	https://pubmed.ncbi.nlm.nih.gov/36574882/
2023	Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes	XIAN WANG	—	https://www.science.org/doi/10.1126/sciadv.ade5321
2023	Magnetically controlled cyclic microscale deformation of in vitro cancer invasion models	Daphne Osk Asgeirsson	—	https://www.researchgate.net/publication/374768956_Magnetically_Controlled_Cyclic_Microscale_Deformation_of_In_Vitro_Cancer_Invasion_Models
2023	Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis	Xinmiao Ji	PMC10017101	https://pmc.ncbi.nlm.nih.gov/articles/PMC10017101/
2022	Rotating Magnetic Field-Assisted Reactor Enhances Mechanisms of Phage Adsorption on Bacterial Cell Surface	Bartłomiej Grygorcewicz	PMC8947294	https://pmc.ncbi.nlm.nih.gov/articles/PMC8947294/
2022	Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice	Shashank Hambarde	36154345	https://pubmed.ncbi.nlm.nih.gov/36154345/
2022	Method and apparatus for oncomagnetic treatment	Helekar et al	—	https://patents.google.com/patent/US12186575B2/en
2022	EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE	Shashank Hambarde	PMC9661114	https://pmc.ncbi.nlm.nih.gov/articles/PMC9661114/
2021	Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications	Katia Varani	PMC7830993	https://pmc.ncbi.nlm.nih.gov/articles/PMC7830993/
2021	Case Report: End-Stage Recurrent Glioblastoma Treated With a New Noninvasive Non-Contact Oncomagnetic Device	David S Baskin	PMC8341943	https://pmc.ncbi.nlm.nih.gov/articles/PMC8341943/
2021	Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields	Santosh A Helekar	34477946	https://pubmed.ncbi.nlm.nih.gov/34477946/
2021	Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields	Sara Lopez	PMC9417452	https://pmc.ncbi.nlm.nih.gov/articles/PMC9417452/
2021	Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF)—An In Vitro Wound Healing Study	Magdalena Jedrzejczak-Silicka	PMC8199476	https://pmc.ncbi.nlm.nih.gov/articles/PMC8199476/
2021	Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials	Huanhuan Lv	PMC7941227	https://pmc.ncbi.nlm.nih.gov/articles/PMC7941227/
2021	Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells	Martyn A Sharpe	PMC8631329	https://pmc.ncbi.nlm.nih.gov/articles/PMC8631329/
2020	Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17	Tianying Zhan	PMC7185125	https://pmc.ncbi.nlm.nih.gov/articles/PMC7185125/
2020	Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibition	Yong Qian	—	https://www.sciencedirect.com/science/article/abs/pii/S1385894720319513
2020	Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance	Yao Chenyang	—	https://m.x-mol.net/paper/article/1307738434868318208
2020	ONCOSCILLATORS: INDUCTION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN CANCER CELLS	Martyn Sharpe	PMC7651633	https://pmc.ncbi.nlm.nih.gov/articles/PMC7651633/
2020	The efficacy and safety of low-frequency rotating static magnetic field therapy combined with chemotherapy on advanced lung cancer patients: a randomized, double-blinded, controlled clinical trial	Minghui Zhu	32238091	https://pubmed.ncbi.nlm.nih.gov/32238091/
2020	Cancer treatment by magneto-mechanical effect of particles, a review	Cécile Naud	PMC9419242	https://pmc.ncbi.nlm.nih.gov/articles/PMC9419242/
2020	Study on the Effect of Rotating Magnetic Field on Cellular Response of Mammalian Cells	Magdalena Jędrzejczak-Silicka	—	https://www.researchgate.net/publication/341242877_Study_on_the_Effect_of_Rotating_Magnetic_Field_on_Cellular_Response_of_Mammalian_Cells
2019	Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans	Jiangyao Xu	—	https://www.researchgate.net/publication/337466667_Rotating_magnetic_field_delays_human_umbilical_vein_endothelial_cell_aging_and_prolongs_the_lifespan_of_Caenorhabditis_elegans
2019	Oncogenic pathways and the electron transport chain: a dangeROS liaison	Vittoria Raimondi	PMC7052168	https://pmc.ncbi.nlm.nih.gov/articles/PMC7052168/
2018	Spatiotemporal magnetic fields enhance cytosolic Ca2+ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells	Mónica Rubio Ayala	—	https://www.sciencedirect.com/science/article/abs/pii/S0142961218301170
2018	Application of Rotating Magnetic Fields Increase the Activity of Antimicrobials Against Wound Biofilm Pathogens	A. F. Junka	—	https://www.nature.com/articles/s41598-017-18557-7
2018	Effect of low-frequency rotary magnetic fields on advanced gastric cancer	Chen, Zheng	29970658	https://journals.lww.com/cancerjournal/fulltext/2018/14040/effect_of_low_frequency_rotary_magnetic_fields_on.15.aspx
2017	LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway	Jing Ren	PMC5429732	https://pmc.ncbi.nlm.nih.gov/articles/PMC5429732/
2017	Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field	Yajing Shen	PMC5436524	https://pmc.ncbi.nlm.nih.gov/articles/PMC5436524/
2017	Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway	Yujun Xu	PMC5603574	https://pmc.ncbi.nlm.nih.gov/articles/PMC5603574/
2016	Early exposure of rotating magnetic fields promotes central nervous regeneration in planarian Girardia sinensis	Qiang Chen	27061713	https://pubmed.ncbi.nlm.nih.gov/27061713/
2016	Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: Potential role for ROS-mediated inhibition on AKT	Ruijing Tang	26807660	https://pubmed.ncbi.nlm.nih.gov/26807660/
2016	Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice	Meng Zha	30142006	https://www.researchgate.net/publication/327213612_Moderate_intensity_low_frequency_rotating_magnetic_field_inhibits_breast_cancer_growth_in_mice
2015	Modification of bacterial cellulose through exposure to the rotating magnetic field	Karol Fijałkowski	26344254	https://pubmed.ncbi.nlm.nih.gov/26344254/
2015	Rotating Magnetic Field Induced Oscillation of Magnetic Particles for in vivo Mechanical Destruction of Malignant Glioma	Yu Cheng	PMC4724455	https://pmc.ncbi.nlm.nih.gov/articles/PMC4724455/
2014	Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells	Leilei Du	25196555	https://pubmed.ncbi.nlm.nih.gov/25196555/
2013	Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma	Yunzhong Nie	PMC3835892	https://pmc.ncbi.nlm.nih.gov/articles/PMC3835892/
2013	Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation	Yunzhong Nie	PMC4029221	https://pmc.ncbi.nlm.nih.gov/articles/PMC4029221/
2012	Magnetoporation and magnetolysis of cancer cells via carbon nanotubes induced by rotating magnetic fields	Dun Liu	22950948	https://pubmed.ncbi.nlm.nih.gov/22950948/
2012	A pilot study of extremely low-frequency magnetic fields in advanced non-small cell lung cancer: Effects on survival and palliation of general symptoms	CHENGTAO SUN	PMC3499610	https://pmc.ncbi.nlm.nih.gov/articles/PMC3499610/
2011	Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells	Tingting Wang	21360556	https://pubmed.ncbi.nlm.nih.gov/21360556/
2008	The hemoprotective effects of a rotary magnetic field in mice exposed to γ irradiation	Xue-jun Xie	—	https://www.semanticscholar.org/paper/The-hemoprotective-effects-of-a-rotary-magnetic-in-Xie-Qi/e39cd1191f5dc087d298977871cea29f76dec0c1
2008	The expression and intranuclear distribution of nucleolin in HL-60 and K-562 cells after repeated, short-term exposition to rotating magnetic fields	Marek Masiuk	18821389	https://pubmed.ncbi.nlm.nih.gov/18821389/
2006	Effects of 0.4 T Rotating Magnetic Field Exposure on Density, Strength, Calcium and Metabolism of Rat Thigh Bones	Xiao-yun Zhang	—	http://www.zgkjcx.com/Article/UploadFiles/200807/20080710121302169.pdf
2001	The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells	Nina Mikirova, Ph.D.	—	https://isom.ca/wp-content/uploads/2020/01/JOM_2001_16_3_10_The_Effect_of_Alternating_Magnetic_Field_Exposure_and-.pdf
2001	Molecular mechanism of effect of rotating constant magnetic field on organisms	X Zhang	18726401	https://pubmed.ncbi.nlm.nih.gov/18726401/
1999	On the mitochondrial aspect of reactive oxygen species action in external magnetic fields	P. Waliszewski	—	https://www.sciencedirect.com/science/article/abs/pii/S1011134499900003?via%3Dihub
1993	The effect of rotating magnetic fields on the growth of Deal's guinea pig sarcoma transplanted subcutaneously in guinea pigs	E Schwartz	8353767	https://pubmed.ncbi.nlm.nih.gov/8353767/
1991	The growth dynamics of Walker carcinosarcoma during exposure to a magnetic eddy field	N G Bakhmutskiĭ	1843148	https://pubmed.ncbi.nlm.nih.gov/1843148/
1991	The assessment of the efficacy of the effect of a rotational magnetic field on the course of the tumor process in patients with generalized breast cancer	N G Bakhmutskiĭ	—	https://pubmed.ncbi.nlm.nih.gov/1948335/

tbResList Print — MFrot Magnetic Field Rotating

Product

Pathway results for Effect on Cancer / Diseased Cells

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Pathway results for Effect on Normal Cells