tbResList Print — betaCar beta-carotene(VitA)

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Product

betaCar beta-carotene(VitA)
Description: <b>Beta carotene</b> is a red-orange pigment found in plants and fruits, especially carrots and colorful vegetables. The body converts beta carotene into vitamin A.<br>
-foods richest in carotenoids include carrots, sweet potatoes, pumpkin, spinach, cantaloupe, apricots and mangoes.<br>
Beta carotene is a carotenoid and an antioxidant.<br>
beta-carotene is known to have pro-oxidant activity in vitro<br>
Beta carotene, a precursor of vitamin A and a well-known antioxidant, has been investigated for its potential roles in cancer prevention and therapy.<br>
<br>
-By mitigating oxidative stress, beta carotene may indirectly reduce NF-κB activation.<br>
-As a lipid-soluble molecule, beta carotene is integrated into cellular membranes, where it helps maintain membrane integrity and fluidity.<br>
-at high concentrations or in the presence of high oxygen tension), beta carotene can exhibit pro-oxidant behavior, which may contribute to cellular damage.<br>
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Pathway results for Effect on Cancer / Diseased Cells

Clinical Biomarkers

BMD↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress

antiOx↑, 2,   ROS↑, 1,   ROS⇅, 1,  

Core Metabolism/Glycolysis

homoC↓, 1,  

Transcription & Epigenetics

other↝, 1,  

Immune & Inflammatory Signaling

Inflam↓, 1,   TNF-α↓, 1,  

Protein Aggregation

Aβ↓, 1,   BACE↓, 1,  

Drug Metabolism & Resistance

BioAv↑, 2,   Dose?, 1,   eff↑, 4,  

Functional Outcomes

cognitive↑, 6,   memory↑, 2,   memory?, 1,   neuroP↑, 2,   Risk↓, 1,  
Total Targets: 17

Research papers

Year Title Authors PMID Link Flag
2023Revisiting the Role of Vitamins and Minerals in Alzheimer’s DiseaseHarsh Shahhttps://www.mdpi.com/2076-3921/12/2/4150
2017Editorial: Impact of Diet on Learning, Memory and CognitionAmy C ReicheltPMC5437154https://pmc.ncbi.nlm.nih.gov/articles/PMC54371540
2017Impact of Diet on Learning, Memory and CognitionAmy C ReicheltPMC5437154https://pmc.ncbi.nlm.nih.gov/articles/PMC54371540
2017Marginal vitamin A deficiency facilitates Alzheimer's pathogenesisJiaying Zeng28130638https://pubmed.ncbi.nlm.nih.gov/28130638/0
2015Effects of egg consumption on carotenoid absorption from co-consumed, raw vegetablesJung Eun KimPMC4480671https://pmc.ncbi.nlm.nih.gov/articles/PMC4480671/0
2012Vitamin A and Alzheimer's diseaseKenjiro Ono22221326https://pubmed.ncbi.nlm.nih.gov/22221326/0
2011Significance of vitamin A to brain function, behavior and learningChristopher R OlsonPMC3169332https://pmc.ncbi.nlm.nih.gov/articles/PMC3169332/0
2004Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detectionMelody J Brown15277161https://pubmed.ncbi.nlm.nih.gov/15277161/0
2004Vitamin A supplementation and risk of skeletal fracturePatrićia de Souza Genaro15080368https://pubmed.ncbi.nlm.nih.gov/15080368/0
2000Antioxidant and pro-oxidant effects of lycopene in comparison with beta-carotene on oxidant-induced damage in Hs68 cellsS Yeh11137891https://pubmed.ncbi.nlm.nih.gov/11137891/0
2000Dietary factors that affect the bioavailability of carotenoidsK H van Het Hof10702576https://pubmed.ncbi.nlm.nih.gov/10702576/0