tbResList Print — Cuc Cucurbitacin

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Product

Cuc Cucurbitacin
Description: <b>Cucurbitacin</b>, produced by some plants, especially Cucurbitaceae, as a defense against herbivores. Toxic compound that can form in plants in the gourd family (Zucchini, Squash).<br>
Cucurbitacins have been shown to inhibit the growth of various cancer cell lines by interfering with cell cycle progression. Cucurbitacins can affect various signaling pathways involved in cancer progression, such as the NF-κB and STAT3 pathways, which are often dysregulated in cancer.<br>

Pathway results for Effect on Cancer / Diseased Cells

Core Metabolism/Glycolysis

ACLY↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2018ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolismCarlotta Granchihttps://www.sciencedirect.com/science/article/abs/pii/S02235234183077360