CPT Camptothecin
Description: <b>Camptothecin (CPT)</b> and its derivatives function as inhibitors of topoisomerase and as potent anticancer agents against a variety of cancers. <br>
Camptothecin is a cytotoxic quinoline alkaloid that is isolated from the bark and fruit of the Camptotheca acuminata tree, native to China. It is a topoisomerase I inhibitor, which means it blocks the enzyme topoisomerase I, an essential enzyme in DNA replication.<br>
Camptothecin derivatives, such as irinotecan and topotecan, have been approved for the treatment of various types of cancer, including colorectal, ovarian, and small cell lung cancer. These derivatives have improved solubility and stability compared to camptothecin, making them more suitable for clinical use.<br>