tbResList Print — TSA Trichostatin A

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Product

TSA Trichostatin A
Description: <b>Trichostatin A (TSA)</b> is a naturally occurring compound that belongs to the class of histone deacetylase inhibitors (HDACis). <br>
TSA has been shown to induce apoptosis (programmed cell death) in various cancer cell lines, including leukemia, breast, and lung cancer cells.<br>

Pathway results for Effect on Cancer / Diseased Cells

NA, unassigned(tgid=0) ⓘ

H3K9↓, 1,   SUV39H↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 2,  
Total Targets: 5

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2016Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticlesNóra Igaz27434153https://pubmed.ncbi.nlm.nih.gov/27434153/0
2013Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin AHuong Thi Thanh TranPMC3565135https://pmc.ncbi.nlm.nih.gov/articles/PMC3565135/0