tbResList Print — MS-275 entinostat

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Product

MS-275 entinostat
Description: <b>Entinostat</b> is a small molecule that was specifically designed to inhibit the activity of histone deacetylases (HDACs), which are enzymes that play a crucial role in the regulation of gene expression.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 2,   Casp9↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2018Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial CellsSangiliyandi GurunathanPMC6222610https://pmc.ncbi.nlm.nih.gov/articles/PMC6222610/0
2007Apoptotic effect of IP6 was not enhanced by co-treatment with myo-inositol in prostate carcinoma PC3 cellsHyun-Jung KimPMC2849022https://pmc.ncbi.nlm.nih.gov/articles/PMC2849022/0