tbResList Print — MS-275 entinostat

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Product

MS-275 entinostat
Description: <b>Entinostat</b> is a small molecule that was specifically designed to inhibit the activity of histone deacetylases (HDACs), which are enzymes that play a crucial role in the regulation of gene expression.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDH↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   Casp9↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Immune & Inflammatory Signaling ⓘ

TNF-α↑, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2018Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial CellsSangiliyandi GurunathanPMC6222610https://pmc.ncbi.nlm.nih.gov/articles/PMC6222610/0