tbResList Print — OXA Oxaliplatin

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Product

OXA Oxaliplatin
Description: <b>Oxaliplatin</b> is a chemotherapy medication used to treat mainly colorectal cancer. It is a platinum-based drug that works by interfering with the DNA of cancer cells, preventing them from reproducing and eventually leading to cell death.<br>
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Oxaliplatin is often used in combination with other chemotherapy medications, such as 5-fluorouracil (5-FU) and leucovorin to treat CRC.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   MAPK↑, 1,  

DNA Damage & Repair ⓘ

P53↝, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   TumCG↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑p65↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   eff↓, 1,   RadioS↑, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2019Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathwayJiahuan YinPMC6529728https://pmc.ncbi.nlm.nih.gov/articles/PMC6529728/0
2025Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivoFang Liu—https://www.nature.com/articles/s41598-025-98633-50
2018Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cellsElisabeth NordenPMC6412115https://pmc.ncbi.nlm.nih.gov/articles/PMC6412115/0