tbResList Print — MTX methotrexate

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Product

MTX methotrexate
Description: <b>Methotrexate</b> is a chemotherapy medication that has been used to treat various types of cancer.<br>
Methotrexate works by:<br>
Inhibiting dihydrofolate reductase (DHFR): Methotrexate binds to DHFR, an enzyme that is necessary for the production of tetrahydrofolate, a co-factor for DNA synthesis.<br>
Interfering with DNA synthesis: By inhibiting DHFR, methotrexate prevents the production of tetrahydrofolate, which is necessary for DNA synthesis.<br>
Inducing apoptosis: Methotrexate can induce apoptosis (programmed cell death) in cancer cells.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress(tgid=1) ⓘ

H2O2↑, 1,  

Cell Death(tgid=5) ⓘ

TumCD↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 2,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 1,   Casp3↓, 2,   Cyt‑c↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   p65↓, 1,   TNF-α↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 2,   RenoP↑, 1,  
Total Targets: 21

Research papers

Year Title Authors PMID Link Flag
2020Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signalingOmnia E. Hussein—https://link.springer.com/article/10.1007/s11356-020-08557-y0
2019Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced ratsAyman M Mahmoud31889292https://pubmed.ncbi.nlm.nih.gov/31889292/0
2019Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal TransitionThomas E. Wallach—https://www.biorxiv.org/content/10.1101/2019.12.23.878207v10
2022Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damageDan Stratton35994829https://www.sciencedirect.com/science/article/pii/S0006291X22011548?via%3Dihub0
2016Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in miceJawad Hassan AhmedPMC5289094https://pmc.ncbi.nlm.nih.gov/articles/PMC5289094/0