tbResList Print — TMZ temozolomide

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Product

TMZ temozolomide
Description: <b>Temozolomide</b> is a chemotherapeutic agent used to treat: GBM<br>
Temozolomide works by interfering with DNA replication: temozolomide is a alkylating agent that adds an alkyl group to the DNA molecule, which interferes with the replication of DNA and ultimately leads to cell death.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   pro‑Casp12↓, 1,   necrosis↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes ⓘ

LC3B-II↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   HR↓, 1,   cl‑PARP↑, 1,   RAD51↓, 1,  

Migration ⓘ

Ca+2↝, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 2,   eff↝, 1,   selectivity↑, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2016Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescenceNancy BertePMC5341871https://pmc.ncbi.nlm.nih.gov/articles/PMC5341871/0
2024Pharmacologic Ascorbate and Ferumoxytol Combined with Temozolomide and Radiation Therapy for the Treatment of Newly Diagnosed GlioblastomaNIH—https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2023-01753&r=10
2014Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagyEncouse B Golden25434381https://pubmed.ncbi.nlm.nih.gov/25434381/0
2012Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma CellsChien-Ju LinPMC3382156https://pmc.ncbi.nlm.nih.gov/articles/PMC3382156/0
2017Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B PathwayJen-Tsung YangPMC5618759https://pmc.ncbi.nlm.nih.gov/articles/PMC5618759/0
2019The role of pyruvate kinase M2 in anticancer therapeutic treatmentsQiongli SuPMC6865080—0