tbResList Print — Catechins Catechins

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Product

Catechins Catechins
Description: <b>Catechins</b> belong to the category of flavanols, which have two isomeric forms, a positive (+) form and a negative (−) form (epicatechin). The (+)-catechins have antioxidative properties, whereas the (−)-epicatechins act as pro-oxidants inducing oxidative effects.<br>
(−)-epicatechins Examples: EGCG, EGC, GCG GC ECTG, EC (all found in green tea, and maybe dark chocolate)<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

H2O2↑, 1,   ROS↑, 1,   mt-ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

lactateProd↓, 1,   LDHA↓, 1,  

Cell Death ⓘ

proApCas↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2021Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-FluorouracilJung Ho HanPMC8161398https://pmc.ncbi.nlm.nih.gov/articles/PMC8161398/0
2003Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen speciesShinji Oikawa14567448https://pubmed.ncbi.nlm.nih.gov/14567448/0