tbResList Print — Phen PXD, phenoxodiol

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Product

Phen PXD, phenoxodiol
Description: <b>Phenoxodiol (PXD)</b> is a synthetic compound that has been investigated as a potential therapeutic agent for the treatment of various types of cancer.<br>
Phenoxodiol is an inhibitor of ENOX2 (ecto-nicotinamide adenine dinucleotide oxidase 2), also known as tNOX (tumor-associated NADH oxidase).<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

ENOX2↓, 2,   NADH↑, 1,  

Cell Death ⓘ

aSmase↑, 1,   SK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2011Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiolLian-Ying Wu—https://www.sciencedirect.com/science/article/abs/pii/S03044165110009360
2010Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa CellsThomas De Luca—https://www.researchgate.net/publication/44644721_Reciprocal_Relationship_Between_Cytosolic_NADH_and_ENOX2_Inhibition_Triggers_Sphingolipid-Induced_Apoptosis_in_HeLa_Cells0