OAA oxaloacetate
Description: </b>Oxaloacetate</b> is a four-carbon dicarboxylic acid that plays a crucial role in the citric acid cycle (Krebs cycle), which is essential for cellular respiration and energy production.
oxaloacetate may have tumor-suppressive properties. <br>
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In the citric acid cycle, oxaloacetate is formed from the condensation of acetyl-CoA and oxaloacetate itself, and it plays a crucial role in the metabolism of carbohydrates, fats, and proteins. It is involved in energy production and the synthesis of various biomolecules.<br>
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Oxaloacetate can also be produced through other metabolic pathways, such as gluconeogenesis and the transamination of aspartate<br>
Oxaloacetate can be derived from several sources and metabolic pathways in the body. Here are the primary sources of oxaloacetate:<br>
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Citric Acid Cycle (Krebs Cycle):<br>
Oxaloacetate is a key intermediate in the citric acid cycle, where it is formed from the condensation of acetyl-CoA and oxaloacetate itself. It is also regenerated at the end of the cycle after the conversion of succinate to fumarate and then to malate.<br>
Gluconeogenesis:<br>
During gluconeogenesis, which is the process of synthesizing glucose from non-carbohydrate precursors, oxaloacetate is produced from pyruvate through the action of the enzyme pyruvate carboxylase. This pathway is particularly important during fasting or intense exercise.<br>
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• Oxaloacetate is a central metabolite in energy metabolism with links to multiple pathways altered in cancer cells (e.g., the TCA cycle, glycolysis, anaplerosis, redox balance, and nucleotide synthesis).<br>