erastin erastin
Description: <b>Erastin</b> is often referred to as a "metabolic inhibitor" or a "ferroptosis inducer", rather than a traditional chemotherapy agent.<br>
Erastin is primarily available as a research chemical—it's not an approved therapeutic for clinical use.<br>
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Pathways:<br>
-Erastin inhibits system xCT, thereby reducing cystine uptake. This leads to decreased intracellular cysteine, a precursor for GSH. As a consequence, the cell’s glutathione levels drop, compromising its ability to neutralize reactive oxygen species (ROS).<br>
-Glutathione (GSH) Depletion and Increased Oxidative Stress<br>
-Voltage-Dependent Anion Channels (VDACs): Altering VDAC function can affect mitochondrial metabolism, leading to changes in energy production and further enhancing oxidative stress.<br>