RSL3 Ras-selective lethal 3
Features: ferroptosis inducer
Description: </b>RSL3 (Ras-selective lethal 3)</b> is a small molecule that has been shown to have anti-cancer properties. It is a ferroptosis inducer, which means that it induces a type of cell death that is characterized by the accumulation of iron and the production of reactive oxygen species (ROS).<br>
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RSL3 works by inhibiting the activity of the enzyme GPX4 (glutathione peroxidase 4), which is involved in the regulation of lipid peroxidation and the maintenance of cellular redox balance. In cancer cells, GPX4 is often overexpressed, and RSL3's inhibition of this enzyme leads to an accumulation of lipid peroxides and a disruption in cellular redox balance.<br>