tbResList Print — Sco Scoulerine

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Product

Sco Scoulerine
Description: <b>Scoulerine</b> is an isoquinoline alkaloid found in various plants (such as members of the Menispermaceae family and in certain Corydalis species) that has attracted interest due to its potential pharmacological activities.<br>
Both scoulerine and berberine belong to the broad family of isoquinoline alkaloids, meaning they share a similar biosynthetic origin and core chemical framework.<br>
– Scoulerine is less commonly encountered in typical dietary sources and is mostly identified in certain herbal extracts from plants in families such as Menispermaceae or Corydalis.<br>
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structurally related benzylisoquinoline alkaloids (e.g., berberine, sanguinarine), so best to refer to those products for more information<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress

GSH↓, 1,   ROS↑, 1,   SOD↓, 1,  

Cell Death

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,  

Transcription & Epigenetics

tumCV↓, 1,  

Protein Folding & ER Stress

CHOP↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

Drug Metabolism & Resistance

eff↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2020Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cellsJiaxun Tian32590070https://pubmed.ncbi.nlm.nih.gov/32590070/0