tbResList Print — Nimb Nimbolide

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Product

Nimb Nimbolide
Description: <b>Nimbolide</b> is a compound found in the neem tree (Azadirachta indica) and has been studied for its potential anti-cancer properties. It is a type of limonoid, a class of compounds that are commonly found in citrus fruits and other plants.<br>
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Research has shown that nimbolide has anti-proliferative and pro-apoptotic effects on various types of cancer cells, including breast, lung, colon, and prostate cancer cells. It has also been shown to inhibit the growth of cancer cells by inducing cell cycle arrest and apoptosis (programmed cell death).<br>
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Some of the ways in which nimbolide may help to prevent or treat cancer include:<br>

-Inhibiting the activity of certain enzymes that are involved in cancer cell growth and survival<br>
-Inducing the production of reactive oxygen species (ROS) that can damage cancer cells<br>
-Inhibiting the formation of new blood vessels that are needed to support the growth of cancer cells<br>
-Enhancing the effectiveness of chemotherapy and radiation therapy<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

Catalase↓, 1,   ROS↑, 6,   SOD↓, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

CAIX↓, 1,   Glycolysis↓, 1,   LDHA↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 8,   Apoptosis↓, 1,   BAX↑, 2,   Bcl-2↓, 3,   Casp↑, 2,   cl‑Casp3↑, 3,   cl‑Casp8↑, 1,   Cyt‑c↑, 1,   MAPK↓, 1,   MCT1↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 3,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   PI3K↓, 2,   STAT↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

ATPase↓, 1,   Ca+2↑, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,  

Barriers & Transport ⓘ

GLUT3↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   JAK↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↓, 1,   eff↓, 2,   selectivity↑, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 48

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2024Insights into Nimbolide molecular crosstalk and its anticancer propertiesShabnum Shaheen—https://link.springer.com/article/10.1007/s12032-024-02379-50
2024Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer CellsXi Chen37103738https://pubmed.ncbi.nlm.nih.gov/37103738/0
2024Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell CarcinomaBou-Yue Peng—https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.244360
2023Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and MetastasisTugba Mehmetoglu-GurbuzPMC10604165https://pmc.ncbi.nlm.nih.gov/articles/PMC10604165/0
2022Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasisPradip Kumar Jaiswara35199915https://pubmed.ncbi.nlm.nih.gov/35199915/0
2021Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug ArsenalSiddavaram Nagini—https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c022390
2016Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transitionRamadevi SubramaniPMC4726267https://pmc.ncbi.nlm.nih.gov/articles/PMC4726267/0
2015Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in OsteosarcomaJu-Fang Liu—https://www.mdpi.com/1422-0067/16/10/234050
2014Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanismsChemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms—https://www.sciencedirect.com/science/article/abs/pii/S08872333140007450