tbResList Print — Est Estrogen

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Product

Est Estrogen
Description: <b>Estrogen</b> is a hormone that plays a crucial role in the development and progression of various types of cancer. (ER-positive cancers).<br>
ER-positive cancers tend to have a better prognosis than ER-negative cancers, as they are more likely to respond to hormone therapy.<br>
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Negative effects of estrogen supplements on cancer:<br>
<b>Breast cancer:</b> Estrogen supplements can increase the risk of breast cancer, particularly in postmenopausal women. This is because estrogen can stimulate the growth of estrogen receptor-positive (ER+) breast cancer cells.<br>
<b>Endometrial cancer:</b> Estrogen supplements can increase the risk of endometrial cancer, particularly in women who have not had a hysterectomy. This is because estrogen can stimulate the growth of endometrial cells, leading to an increased risk of cancer.<br>
<b>Ovarian cancer:</b> Some studies suggest that estrogen supplements may increase the risk of ovarian cancer, although the evidence is not conclusive.<br>
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Positive effects of estrogen supplements on cancer:<br>
<b>Colorectal cancer:</b> Some studies suggest that estrogen supplements may reduce the risk of colorectal cancer, particularly in postmenopausal women.<br>
<b>Prostate cancer:</b> Estrogen supplements may have a protective effect on prostate cancer, although the evidence is not conclusive.<br>

Pathway results for Effect on Cancer / Diseased Cells

Core Metabolism/Glycolysis

cMyc↑, 1,   GLS↑, 1,   GlutMet↑, 1,  

Transcription & Epigenetics

tumCV↑, 1,  

Autophagy & Lysosomes

TumAuto↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2019Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolismWen-Jie ZhouPMC6700828https://pmc.ncbi.nlm.nih.gov/articles/PMC6700828/1