tbResList Print — ProBio probiotics

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Product

ProBio probiotics
Description: <b>Probiotics</b> contain live bacteria the supplements the gastrointestinal flora. (Which can be affected from infection or antibiotics drugs.)<br>
Some studies have suggested that gut microbiota—including Bifidobacterium species—can affect systemic immunity. This is important because the state of the immune system influences the body’s ability to fight cancer and also the response to immunotherapies.<br>
Preclinical investigations have demonstrated that certain Bifidobacterium strains may help improve responses to immune checkpoint inhibitors in animal models. <br>
There has been emerging research looking into discrete strains or formulations of Bifidobacterium longum (sometimes labeled with additional identifiers such as RAPO) that may have unique properties or enhanced effects.<br>

Pathway results for Effect on Cancer / Diseased Cells

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

ZO-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

DCells↑, 1,   IL10↓, 1,   IL12↓, 1,   IL22↓, 1,   IL6↓, 1,   Imm↝, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 4,   eff↑, 3,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 2,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   toxicity↓, 1,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,   Diar⇅, 1,   Diar↓, 1,   Inf↓, 2,  
Total Targets: 25

Pathway results for Effect on Normal Cells

NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 2,   GutMicro∅, 1,   GutMicro↝, 3,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   memory↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Diar↓, 1,  
Total Targets: 20

Research papers

Year Title Authors PMID Link Flag
2019Impacts of dietary silver nanoparticles and probiotic administration on the microbiota of an in-vitro gut modelCristina Cattò—https://www.sciencedirect.com/science/article/abs/pii/S02697491183360290
2025Gut microbiota shapes cancer immunotherapy responsesWanting LeiPMC12297587https://pmc.ncbi.nlm.nih.gov/articles/PMC12297587/0
2026Probiotics in colorectal cancer: mechanisms, biomarkers, and adjunct strategiesZihe XuPMC13244304https://pmc.ncbi.nlm.nih.gov/articles/PMC13244304/0
2013The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trialZhi-Hua Liu23235200https://pubmed.ncbi.nlm.nih.gov/23235200/0
2011Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery - a double-blind studyZ Liu21083585https://pubmed.ncbi.nlm.nih.gov/21083585/0
2025EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTSGabriel Caio DE SOUZAPMC12683943https://pmc.ncbi.nlm.nih.gov/articles/PMC12683943/0
2025ProbioticsNIH—https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/0
2023Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesisStefanie Grabrucker—https://academic.oup.com/brain/article/146/12/4916/73086870
2021Combination Therapy of Bifidobacterium longum RAPO With Anti-PD-1 Treatment Enhances Anti-tumor Immune Response in Association With Gut Microbiota ModulationHyeyoon Kim—https://www.sciencedirect.com/science/article/pii/S24752991231164900
2019A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancerLiyana ZaharuddinPMC6657028https://pmc.ncbi.nlm.nih.gov/articles/PMC6657028/0
2013Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serineHelene M SavignacPMC3858812https://pmc.ncbi.nlm.nih.gov/articles/PMC3858812/0
2021Vitamin K2 Holds Promise for Alzheimer's Prevention and TreatmentAlexander PopescuPMC8308377https://pmc.ncbi.nlm.nih.gov/articles/PMC8308377/0