tbResList Print — ProBio probiotics

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Product

ProBio probiotics
Description: <b>Probiotics</b> contain live bacteria the supplements the gastrointestinal flora. (Which can be affected from infection or antibiotics drugs.)<br>
Some studies have suggested that gut microbiota—including Bifidobacterium species—can affect systemic immunity. This is important because the state of the immune system influences the body’s ability to fight cancer and also the response to immunotherapies.<br>
Preclinical investigations have demonstrated that certain Bifidobacterium strains may help improve responses to immune checkpoint inhibitors in animal models. <br>
There has been emerging research looking into discrete strains or formulations of Bifidobacterium longum (sometimes labeled with additional identifiers such as RAPO) that may have unique properties or enhanced effects.<br>

Pathway results for Effect on Cancer / Diseased Cells

Transcription & Epigenetics

other↑, 1,  

Immune & Inflammatory Signaling

DCells↑, 1,   IL10↓, 1,   IL12↓, 1,   IL22↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance

Dose↝, 2,   eff↑, 2,   selectivity↑, 1,  

Clinical Biomarkers

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes

AntiTum↑, 1,   toxicity↓, 1,   TumVol↓, 1,  

Infection & Microbiome

CD8+↑, 1,   Diar⇅, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress

antiOx↑, 1,   GSH↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics

ATP↑, 1,  

Transcription & Epigenetics

other↝, 2,  

Immune & Inflammatory Signaling

Inflam↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission

BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation

Aβ↓, 1,  

Clinical Biomarkers

GutMicro↑, 1,   GutMicro∅, 1,   GutMicro↝, 3,  

Functional Outcomes

cardioP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   memory↑, 2,  
Total Targets: 17

Research papers

Year Title Authors PMID Link Flag
2019Impacts of dietary silver nanoparticles and probiotic administration on the microbiota of an in-vitro gut modelCristina Cattòhttps://www.sciencedirect.com/science/article/abs/pii/S02697491183360290
2025Gut microbiota shapes cancer immunotherapy responsesWanting LeiPMC12297587https://pmc.ncbi.nlm.nih.gov/articles/PMC12297587/0
2025EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTSGabriel Caio DE SOUZAPMC12683943https://pmc.ncbi.nlm.nih.gov/articles/PMC12683943/0
2023Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesisStefanie Grabruckerhttps://academic.oup.com/brain/article/146/12/4916/73086870
2021Combination Therapy of Bifidobacterium longum RAPO With Anti-PD-1 Treatment Enhances Anti-tumor Immune Response in Association With Gut Microbiota ModulationHyeyoon Kimhttps://www.sciencedirect.com/science/article/pii/S24752991231164900
2019A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancerLiyana ZaharuddinPMC6657028https://pmc.ncbi.nlm.nih.gov/articles/PMC6657028/0
2013Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serineHelene M SavignacPMC3858812https://pmc.ncbi.nlm.nih.gov/articles/PMC3858812/0
2021Vitamin K2 Holds Promise for Alzheimer's Prevention and TreatmentAlexander PopescuPMC8308377https://pmc.ncbi.nlm.nih.gov/articles/PMC8308377/0