tbResList Print — Tras Trastuzumab

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Product

Tras Trastuzumab
Description: <b>Trastuzumab</b> is a targeted therapy used in the treatment of certain types of cancer, most notably HER2-positive breast cancer. <br>
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It specifically targets the human epidermal growth factor receptor 2 (HER2), a protein that is overexpressed in some types of breast cancer and other cancers.<br>
-Is a Her2 inhibitor used in breast cancer. <br>
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Trastuzumab has revolutionized the treatment of HER2-positive breast cancer, significantly improving both response rates and overall survival.<br>

Pathway results for Effect on Cancer / Diseased Cells

Cell Death

Akt↓, 1,  

Kinase & Signal Transduction

HER2/EBBR2↓, 1,  

Autophagy & Lysosomes

p62↑, 1,  

Proliferation, Differentiation & Cell State

mTOR↓, 1,   PI3K↓, 1,  

Drug Metabolism & Resistance

ChemoSen↑, 1,  

Clinical Biomarkers

HER2/EBBR2↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2017Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cellsCarolina D’AlesioPMC5670707https://pmc.ncbi.nlm.nih.gov/articles/PMC5670707/0