tbResList Print — carbop carboplatin

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Product

carbop carboplatin
Description: <b>Carboplatin</b> is a platinum-based chemotherapy drug, structurally related to cisplatin.<br>
Advantages Over Cisplatin:<br>
• Compared to cisplatin, carboplatin is associated with a more favorable side-effect profile, particularly with regard to reduced nephrotoxicity (renal toxicity).<br>
• However, it may still cause bone marrow suppression, so careful monitoring of blood counts is essential.<br>
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Carboplatin is a key platinum-based chemotherapy agent that interferes with cancer cell DNA, leading to cell death. Its relatively favorable toxicity profile, compared to cisplatin, makes it a popular choice for treating a variety of solid tumors such as ovarian, lung, head and neck, bladder, and certain cases of testicular cancers. Due to its side-effect profile, particularly bone marrow suppression, patients receiving carboplatin require careful monitoring and dosage adjustments based on their renal function and other clinical factors.<br>

Pathway results for Effect on Cancer / Diseased Cells

Cell Death

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

DNA Damage & Repair

P53↑, 1,  

Cell Cycle & Senescence

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State

ALDH1A1↓, 1,   LRP6↓, 1,   Wnt/(β-catenin)↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2021Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell lineNora M Aborehab33002289https://pubmed.ncbi.nlm.nih.gov/33002289/0
2014Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancerRebecca C Arend24736023https://pubmed.ncbi.nlm.nih.gov/24736023/0